Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease.
Identifieur interne : 000F73 ( Ncbi/Checkpoint ); précédent : 000F72; suivant : 000F74Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease.
Auteurs : Lars Timmermann [Allemagne] ; Lars Wojtecki ; Joachim Gross ; Ralph Lehrke ; Jürgen Voges ; Mohammed Maarouf ; Harald Treuer ; Volker Sturm ; Alfons SchnitzlerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2004.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Dominance, Cerebral (physiology), Drug Therapy, Combination, Electric Conductivity, Electric Stimulation Therapy, Electrodes, Implanted, Female, Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Middle Aged, Motor Activity (physiology), Nerve Net (physiopathology), Neurologic Examination, Parkinson Disease (physiopathology), Parkinson Disease (therapy), Stereotaxic Techniques, Subthalamic Nucleus (physiopathology), Surgery, Computer-Assisted, Treatment Failure, Tremor (physiopathology), Tremor (therapy).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- physiology : Dominance, Cerebral, Motor Activity.
- physiopathology : Nerve Net, Parkinson Disease, Subthalamic Nucleus, Tremor.
- therapy : Parkinson Disease, Tremor.
- Aged, Drug Therapy, Combination, Electric Conductivity, Electric Stimulation Therapy, Electrodes, Implanted, Female, Humans, Male, Middle Aged, Neurologic Examination, Stereotaxic Techniques, Surgery, Computer-Assisted, Treatment Failure.
Abstract
Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation (> or =130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD.
DOI: 10.1002/mds.20198
PubMed: 15389990
Affiliations:
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Gross</name></author><author><name sortKey="Lehrke, Ralph" sort="Lehrke, Ralph" uniqKey="Lehrke R" first="Ralph" last="Lehrke">Ralph Lehrke</name></author><author><name sortKey="Voges, Jurgen" sort="Voges, Jurgen" uniqKey="Voges J" first="Jürgen" last="Voges">Jürgen Voges</name></author><author><name sortKey="Maarouf, Mohammed" sort="Maarouf, Mohammed" uniqKey="Maarouf M" first="Mohammed" last="Maarouf">Mohammed Maarouf</name></author><author><name sortKey="Treuer, Harald" sort="Treuer, Harald" uniqKey="Treuer H" first="Harald" last="Treuer">Harald Treuer</name></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno 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Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name></author><author><name sortKey="Gross, Joachim" sort="Gross, Joachim" uniqKey="Gross J" first="Joachim" last="Gross">Joachim Gross</name></author><author><name sortKey="Lehrke, Ralph" sort="Lehrke, Ralph" uniqKey="Lehrke R" first="Ralph" last="Lehrke">Ralph Lehrke</name></author><author><name sortKey="Voges, Jurgen" sort="Voges, Jurgen" uniqKey="Voges J" first="Jürgen" last="Voges">Jürgen Voges</name></author><author><name sortKey="Maarouf, Mohammed" sort="Maarouf, Mohammed" uniqKey="Maarouf M" first="Mohammed" last="Maarouf">Mohammed Maarouf</name></author><author><name sortKey="Treuer, Harald" sort="Treuer, Harald" uniqKey="Treuer H" first="Harald" last="Treuer">Harald Treuer</name></author><author><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (adverse effects)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Dominance, Cerebral (physiology)</term><term>Drug Therapy, Combination</term><term>Electric Conductivity</term><term>Electric Stimulation Therapy</term><term>Electrodes, Implanted</term><term>Female</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Nerve Net (physiopathology)</term><term>Neurologic Examination</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Stereotaxic Techniques</term><term>Subthalamic Nucleus (physiopathology)</term><term>Surgery, Computer-Assisted</term><term>Treatment Failure</term><term>Tremor (physiopathology)</term><term>Tremor (therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Nerve Net</term><term>Parkinson Disease</term><term>Subthalamic Nucleus</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Drug Therapy, Combination</term><term>Electric Conductivity</term><term>Electric Stimulation Therapy</term><term>Electrodes, Implanted</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Stereotaxic Techniques</term><term>Surgery, Computer-Assisted</term><term>Treatment Failure</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation (> or =130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Gross, Joachim" sort="Gross, Joachim" uniqKey="Gross J" first="Joachim" last="Gross">Joachim Gross</name><name sortKey="Lehrke, Ralph" sort="Lehrke, Ralph" uniqKey="Lehrke R" first="Ralph" last="Lehrke">Ralph Lehrke</name><name sortKey="Maarouf, Mohammed" sort="Maarouf, Mohammed" uniqKey="Maarouf M" first="Mohammed" last="Maarouf">Mohammed Maarouf</name><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><name sortKey="Sturm, Volker" sort="Sturm, Volker" uniqKey="Sturm V" first="Volker" last="Sturm">Volker Sturm</name><name sortKey="Treuer, Harald" sort="Treuer, Harald" uniqKey="Treuer H" first="Harald" last="Treuer">Harald Treuer</name><name sortKey="Voges, Jurgen" sort="Voges, Jurgen" uniqKey="Voges J" first="Jürgen" last="Voges">Jürgen Voges</name><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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