Patterns of EMG-EMG coherence in limb dystonia.
Identifieur interne : 000E65 ( Ncbi/Checkpoint ); précédent : 000E64; suivant : 000E66Patterns of EMG-EMG coherence in limb dystonia.
Auteurs : Pascal Grosse [Royaume-Uni] ; M. Edwards ; M A J. Tijssen ; A. Schrag ; Andrew J. Lees ; K P Bhatia ; Peter BrownSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Anterior Compartment Syndrome (complications), Anterior Compartment Syndrome (physiopathology), Anti-Dyskinesia Agents (therapeutic use), Anticonvulsants (therapeutic use), Antiparkinson Agents (therapeutic use), Basal Ganglia Diseases (complications), Basal Ganglia Diseases (pathology), Basal Ganglia Diseases (physiopathology), Botulinum Toxins (therapeutic use), Clonazepam (therapeutic use), Dystonia (drug therapy), Dystonia (etiology), Dystonia (physiopathology), Electromyography (instrumentation), Electromyography (statistics & numerical data), Female, Humans, Male, Middle Aged, Molecular Chaperones (genetics), Trihexyphenidyl (therapeutic use).
- MESH :
- chemical , genetics : Molecular Chaperones.
- chemical , therapeutic use : Anti-Dyskinesia Agents, Anticonvulsants, Antiparkinson Agents, Botulinum Toxins, Clonazepam, Trihexyphenidyl.
- complications : Anterior Compartment Syndrome, Basal Ganglia Diseases.
- drug therapy : Dystonia.
- etiology : Dystonia.
- instrumentation : Electromyography.
- pathology : Basal Ganglia Diseases.
- physiopathology : Anterior Compartment Syndrome, Basal Ganglia Diseases, Dystonia.
- statistics & numerical data : Electromyography.
- Adult, Female, Humans, Male, Middle Aged.
Abstract
Dystonia of the limbs may be due to a wide range of aetiologies and may cause major functional limitation. We investigated whether the previously described pathological 4 to 7 Hz drive to muscles in cervical dystonia is present in patients with aetiologically different types of dystonia of the upper and lower limbs. To this end, we studied 12 symptomatic and 4 asymptomatic carriers of the DYT1 gene, 6 patients with symptomatic dystonia due to focal basal ganglia lesions, and 11 patients with fixed dystonia, a condition assumed to be mostly psychogenic in aetiology. We evaluated EMG-EMG coherence in the tibialis anterior (TA) of these and 15 healthy control subjects. Ten of 12 (83%) of symptomatic DYT1 patients had an excessive 4 to 7 Hz common drive to TA, evident as an inflated coherence in this band. This drive also involved the gastrocnemius, leading to co-contracting electromyographic bursts. In contrast, asymptomatic DYT1 carriers, patients with symptomatic dystonia, patients with fixed dystonia, and healthy subjects showed no evidence of such a drive or any other distinguishing electrophysiological feature. Moreover, the pathological 4 to 7 Hz drive in symptomatic DYT1 patients was much less common in the upper limb, where it was only present in 2 of 6 (33%) patients with clinical involvement of the arms. We conclude that the nature of the abnormal drive to dystonic muscles may vary according to the muscles under consideration and, particularly, with aetiology.
DOI: 10.1002/mds.20075
PubMed: 15254933
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003419
- to stream PubMed, to step Curation: 003419
- to stream PubMed, to step Checkpoint: 003371
- to stream Ncbi, to step Merge: 000E65
- to stream Ncbi, to step Curation: 000E65
Links to Exploration step
pubmed:15254933Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Patterns of EMG-EMG coherence in limb dystonia.</title><author><name sortKey="Grosse, Pascal" sort="Grosse, Pascal" uniqKey="Grosse P" first="Pascal" last="Grosse">Pascal Grosse</name><affiliation wicri:level="3"><nlm:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom. p.grosse@ion.ucl.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Edwards, M" sort="Edwards, M" uniqKey="Edwards M" first="M" last="Edwards">M. Edwards</name></author><author><name sortKey="Tijssen, M A J" sort="Tijssen, M A J" uniqKey="Tijssen M" first="M A J" last="Tijssen">M A J. Tijssen</name></author><author><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A" last="Schrag">A. Schrag</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name></author><author><name sortKey="Bhatia, K P" sort="Bhatia, K P" uniqKey="Bhatia K" first="K P" last="Bhatia">K P Bhatia</name></author><author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15254933</idno><idno type="pmid">15254933</idno><idno type="doi">10.1002/mds.20075</idno><idno type="wicri:Area/PubMed/Corpus">003419</idno><idno type="wicri:Area/PubMed/Curation">003419</idno><idno type="wicri:Area/PubMed/Checkpoint">003371</idno><idno type="wicri:Area/Ncbi/Merge">000E65</idno><idno type="wicri:Area/Ncbi/Curation">000E65</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E65</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Patterns of EMG-EMG coherence in limb dystonia.</title><author><name sortKey="Grosse, Pascal" sort="Grosse, Pascal" uniqKey="Grosse P" first="Pascal" last="Grosse">Pascal Grosse</name><affiliation wicri:level="3"><nlm:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom. p.grosse@ion.ucl.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Edwards, M" sort="Edwards, M" uniqKey="Edwards M" first="M" last="Edwards">M. Edwards</name></author><author><name sortKey="Tijssen, M A J" sort="Tijssen, M A J" uniqKey="Tijssen M" first="M A J" last="Tijssen">M A J. Tijssen</name></author><author><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A" last="Schrag">A. Schrag</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name></author><author><name sortKey="Bhatia, K P" sort="Bhatia, K P" uniqKey="Bhatia K" first="K P" last="Bhatia">K P Bhatia</name></author><author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anterior Compartment Syndrome (complications)</term><term>Anterior Compartment Syndrome (physiopathology)</term><term>Anti-Dyskinesia Agents (therapeutic use)</term><term>Anticonvulsants (therapeutic use)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Basal Ganglia Diseases (complications)</term><term>Basal Ganglia Diseases (pathology)</term><term>Basal Ganglia Diseases (physiopathology)</term><term>Botulinum Toxins (therapeutic use)</term><term>Clonazepam (therapeutic use)</term><term>Dystonia (drug therapy)</term><term>Dystonia (etiology)</term><term>Dystonia (physiopathology)</term><term>Electromyography (instrumentation)</term><term>Electromyography (statistics & numerical data)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Chaperones (genetics)</term><term>Trihexyphenidyl (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Molecular Chaperones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Anticonvulsants</term><term>Antiparkinson Agents</term><term>Botulinum Toxins</term><term>Clonazepam</term><term>Trihexyphenidyl</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Anterior Compartment Syndrome</term><term>Basal Ganglia Diseases</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia Diseases</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Anterior Compartment Syndrome</term><term>Basal Ganglia Diseases</term><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Electromyography</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dystonia of the limbs may be due to a wide range of aetiologies and may cause major functional limitation. We investigated whether the previously described pathological 4 to 7 Hz drive to muscles in cervical dystonia is present in patients with aetiologically different types of dystonia of the upper and lower limbs. To this end, we studied 12 symptomatic and 4 asymptomatic carriers of the DYT1 gene, 6 patients with symptomatic dystonia due to focal basal ganglia lesions, and 11 patients with fixed dystonia, a condition assumed to be mostly psychogenic in aetiology. We evaluated EMG-EMG coherence in the tibialis anterior (TA) of these and 15 healthy control subjects. Ten of 12 (83%) of symptomatic DYT1 patients had an excessive 4 to 7 Hz common drive to TA, evident as an inflated coherence in this band. This drive also involved the gastrocnemius, leading to co-contracting electromyographic bursts. In contrast, asymptomatic DYT1 carriers, patients with symptomatic dystonia, patients with fixed dystonia, and healthy subjects showed no evidence of such a drive or any other distinguishing electrophysiological feature. Moreover, the pathological 4 to 7 Hz drive in symptomatic DYT1 patients was much less common in the upper limb, where it was only present in 2 of 6 (33%) patients with clinical involvement of the arms. We conclude that the nature of the abnormal drive to dystonic muscles may vary according to the muscles under consideration and, particularly, with aetiology.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Bhatia, K P" sort="Bhatia, K P" uniqKey="Bhatia K" first="K P" last="Bhatia">K P Bhatia</name><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name><name sortKey="Edwards, M" sort="Edwards, M" uniqKey="Edwards M" first="M" last="Edwards">M. Edwards</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A" last="Schrag">A. Schrag</name><name sortKey="Tijssen, M A J" sort="Tijssen, M A J" uniqKey="Tijssen M" first="M A J" last="Tijssen">M A J. Tijssen</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Grosse, Pascal" sort="Grosse, Pascal" uniqKey="Grosse P" first="Pascal" last="Grosse">Pascal Grosse</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E65 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000E65 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:15254933
|texte= Patterns of EMG-EMG coherence in limb dystonia.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:15254933" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |