Long-term follow-up of cervical dystonia patients treated with botulinum toxin A.
Identifieur interne : 000D52 ( Ncbi/Checkpoint ); précédent : 000D51; suivant : 000D53Long-term follow-up of cervical dystonia patients treated with botulinum toxin A.
Auteurs : Peter Haussermann [Allemagne] ; Stefanie Marczoch ; Christiane Klinger ; Michael Landgrebe ; Bastian Conrad ; Andres Ceballos-BaumannSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Botulinum Toxins, Type A (adverse effects), Botulinum Toxins, Type A (therapeutic use), Cohort Studies, Dystonic Disorders (chemically induced), Female, Follow-Up Studies, Humans, Male, Meige Syndrome (chemically induced), Middle Aged, Neuromuscular Agents (adverse effects), Neuromuscular Agents (therapeutic use), Quality of Life, Questionnaires, Time Factors, Torticollis (drug therapy), Torticollis (epidemiology).
- MESH :
- chemical , adverse effects : Botulinum Toxins, Type A, Neuromuscular Agents.
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- chemically induced : Dystonic Disorders, Meige Syndrome.
- drug therapy : Torticollis.
- epidemiology : Torticollis.
- Adult, Cohort Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Quality of Life, Questionnaires, Time Factors.
Abstract
We followed the course in 100 consecutive patients with cervical dystonia (CD) after they were initially treated with botulinum toxin (BTX) in the form of Dysport 10 to 12 years ago. A total of 4 patients had died, and 6 were lost to follow-up. Of the remaining 90 patients, 57 (63%) were still treated with BTX. In the patients treated at one centre over the whole period with Dysport, mean dose used during each treatment session was 833 (SD +/- 339) units Dysport with a cumulative dose of 20,943 (SD +/- 9462) units Dysport over a mean of 26.8 (SD +/- 8.6) treatment cycles. Secondary nonresponse was detected in 3 of the 90 patients. During follow-up, 12 patients developed blepharospasm, 13 oromandibular dystonia, and 17 patients writer's cramp. We conclude that BTX remains effective and safe for approximately 60% of CD patients for more than 10 years.
DOI: 10.1002/mds.10659
PubMed: 15022184
Affiliations:
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last="Marczoch">Stefanie Marczoch</name></author><author><name sortKey="Klinger, Christiane" sort="Klinger, Christiane" uniqKey="Klinger C" first="Christiane" last="Klinger">Christiane Klinger</name></author><author><name sortKey="Landgrebe, Michael" sort="Landgrebe, Michael" uniqKey="Landgrebe M" first="Michael" last="Landgrebe">Michael Landgrebe</name></author><author><name sortKey="Conrad, Bastian" sort="Conrad, Bastian" uniqKey="Conrad B" first="Bastian" last="Conrad">Bastian Conrad</name></author><author><name sortKey="Ceballos Baumann, Andres" sort="Ceballos Baumann, Andres" uniqKey="Ceballos Baumann A" first="Andres" last="Ceballos-Baumann">Andres Ceballos-Baumann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15022184</idno><idno type="pmid">15022184</idno><idno type="doi">10.1002/mds.10659</idno><idno type="wicri:Area/PubMed/Corpus">003532</idno><idno 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type="district" nuts="2">District de Haute-Bavière</region></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Marczoch, Stefanie" sort="Marczoch, Stefanie" uniqKey="Marczoch S" first="Stefanie" last="Marczoch">Stefanie Marczoch</name></author><author><name sortKey="Klinger, Christiane" sort="Klinger, Christiane" uniqKey="Klinger C" first="Christiane" last="Klinger">Christiane Klinger</name></author><author><name sortKey="Landgrebe, Michael" sort="Landgrebe, Michael" uniqKey="Landgrebe M" first="Michael" last="Landgrebe">Michael Landgrebe</name></author><author><name sortKey="Conrad, Bastian" sort="Conrad, Bastian" uniqKey="Conrad B" first="Bastian" last="Conrad">Bastian Conrad</name></author><author><name sortKey="Ceballos Baumann, Andres" sort="Ceballos Baumann, Andres" uniqKey="Ceballos Baumann A" first="Andres" last="Ceballos-Baumann">Andres Ceballos-Baumann</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Botulinum Toxins, Type A (adverse effects)</term><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Cohort Studies</term><term>Dystonic Disorders (chemically induced)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Meige Syndrome (chemically induced)</term><term>Middle Aged</term><term>Neuromuscular Agents (adverse effects)</term><term>Neuromuscular Agents (therapeutic use)</term><term>Quality of Life</term><term>Questionnaires</term><term>Time Factors</term><term>Torticollis (drug therapy)</term><term>Torticollis (epidemiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Botulinum Toxins, Type A</term><term>Neuromuscular Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term><term>Neuromuscular Agents</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Dystonic Disorders</term><term>Meige Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Torticollis</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Torticollis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Quality of Life</term><term>Questionnaires</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We followed the course in 100 consecutive patients with cervical dystonia (CD) after they were initially treated with botulinum toxin (BTX) in the form of Dysport 10 to 12 years ago. A total of 4 patients had died, and 6 were lost to follow-up. Of the remaining 90 patients, 57 (63%) were still treated with BTX. In the patients treated at one centre over the whole period with Dysport, mean dose used during each treatment session was 833 (SD +/- 339) units Dysport with a cumulative dose of 20,943 (SD +/- 9462) units Dysport over a mean of 26.8 (SD +/- 8.6) treatment cycles. Secondary nonresponse was detected in 3 of the 90 patients. During follow-up, 12 patients developed blepharospasm, 13 oromandibular dystonia, and 17 patients writer's cramp. We conclude that BTX remains effective and safe for approximately 60% of CD patients for more than 10 years.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement><orgName><li>Université technique de Munich</li></orgName></list><tree><noCountry><name sortKey="Ceballos Baumann, Andres" sort="Ceballos Baumann, Andres" uniqKey="Ceballos Baumann A" first="Andres" last="Ceballos-Baumann">Andres Ceballos-Baumann</name><name sortKey="Conrad, Bastian" sort="Conrad, Bastian" uniqKey="Conrad B" first="Bastian" last="Conrad">Bastian Conrad</name><name sortKey="Klinger, Christiane" sort="Klinger, Christiane" uniqKey="Klinger C" first="Christiane" last="Klinger">Christiane Klinger</name><name sortKey="Landgrebe, Michael" sort="Landgrebe, Michael" uniqKey="Landgrebe M" first="Michael" last="Landgrebe">Michael Landgrebe</name><name sortKey="Marczoch, Stefanie" sort="Marczoch, Stefanie" uniqKey="Marczoch S" first="Stefanie" last="Marczoch">Stefanie Marczoch</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Haussermann, Peter" sort="Haussermann, Peter" uniqKey="Haussermann P" first="Peter" last="Haussermann">Peter Haussermann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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