Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in parkinsonian rats.
Identifieur interne : 000926 ( Ncbi/Checkpoint ); précédent : 000925; suivant : 000927Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in parkinsonian rats.
Auteurs : Marie-Paule Muriel [France] ; Gaël Orieux ; Etienne C. HirschSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.
English descriptors
- KwdEn :
- Animals, Antiparkinson Agents (pharmacology), Carbidopa (pharmacology), Corpus Striatum (drug effects), Corpus Striatum (pathology), Cytoplasm (drug effects), Cytoplasm (pathology), Drug Combinations, Indoles (pharmacology), Levodopa (pharmacology), Male, Microscopy, Immunoelectron, Neurons (drug effects), Neurons (pathology), Oxidopamine, Parkinsonian Disorders (chemically induced), Parkinsonian Disorders (pathology), Rats, Rats, Sprague-Dawley, Receptors, Dopamine D1 (drug effects), Synaptic Membranes (drug effects), Synaptic Membranes (pathology), Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , drug effects : Receptors, Dopamine D1.
- chemical , metabolism : Tyrosine 3-Monooxygenase.
- chemical , pharmacology : Antiparkinson Agents, Carbidopa, Indoles, Levodopa.
- chemically induced : Parkinsonian Disorders.
- drug effects : Corpus Striatum, Cytoplasm, Neurons, Synaptic Membranes.
- pathology : Corpus Striatum, Cytoplasm, Neurons, Parkinsonian Disorders, Synaptic Membranes.
- Animals, Drug Combinations, Male, Microscopy, Immunoelectron, Oxidopamine, Rats, Rats, Sprague-Dawley.
Abstract
Levodopa therapy in Parkinson's disease is mediated by dopamine receptors and, in a recent study, we showed that a Dl full agonist can induce an internalization of D1 dopamine receptors. The aim of the present study was to determine whether levodopa or a dopamine agonist such as ropinirole can also induce the internalization of D1 dopamine receptors in the striatum of control and hemiparkinsonian rats. The distribution of D1 dopamine receptors was analyzed by immunohistochemistry using a specific antibody. In control animals and 6-hydroxydopamine (6-OHDA)-lesioned animals treated with saline, D1 dopamine receptors were localized at the level of the plasma membrane. In contrast, in both lesioned and nonlesioned animals receiving a single dose of levodopa, but not in animals receiving ropinirole, D1 dopamine receptors were internalized in the cytoplasm. This result is likely explained by the fact that ropinirole binds to non-D1 dopamine receptors, whereas levodopa, which increases dopamine levels, indirectly acts on both D1 and D2 receptors. Ropinirole is consequently less likely to desensitize D1 dopamine receptors than levodopa and, thus, to reduce the efficacy of the treatment.
DOI: 10.1002/mds.10256
PubMed: 12465054
Affiliations:
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Hirsch</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:12465054</idno><idno type="pmid">12465054</idno><idno type="doi">10.1002/mds.10256</idno><idno type="wicri:Area/PubMed/Corpus">003925</idno><idno type="wicri:Area/PubMed/Curation">003925</idno><idno type="wicri:Area/PubMed/Checkpoint">003A42</idno><idno type="wicri:Area/Ncbi/Merge">000926</idno><idno type="wicri:Area/Ncbi/Curation">000926</idno><idno type="wicri:Area/Ncbi/Checkpoint">000926</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Levodopa but not ropinirole induces an internalization of D1 dopamine receptors in parkinsonian rats.</title><author><name sortKey="Muriel, Marie Paule" sort="Muriel, Marie Paule" uniqKey="Muriel M" first="Marie-Paule" last="Muriel">Marie-Paule Muriel</name><affiliation wicri:level="1"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale U 289, Hôpital de la salpêtrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale U 289, Hôpital de la salpêtrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Orieux, Gael" sort="Orieux, Gael" uniqKey="Orieux G" first="Gaël" last="Orieux">Gaël Orieux</name></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. Hirsch</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiparkinson Agents (pharmacology)</term><term>Carbidopa (pharmacology)</term><term>Corpus Striatum (drug effects)</term><term>Corpus Striatum (pathology)</term><term>Cytoplasm (drug effects)</term><term>Cytoplasm (pathology)</term><term>Drug Combinations</term><term>Indoles (pharmacology)</term><term>Levodopa (pharmacology)</term><term>Male</term><term>Microscopy, Immunoelectron</term><term>Neurons (drug effects)</term><term>Neurons (pathology)</term><term>Oxidopamine</term><term>Parkinsonian Disorders (chemically induced)</term><term>Parkinsonian Disorders (pathology)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Receptors, Dopamine D1 (drug effects)</term><term>Synaptic Membranes (drug effects)</term><term>Synaptic Membranes (pathology)</term><term>Tyrosine 3-Monooxygenase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, Dopamine D1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term><term>Carbidopa</term><term>Indoles</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Corpus Striatum</term><term>Cytoplasm</term><term>Neurons</term><term>Synaptic Membranes</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Cytoplasm</term><term>Neurons</term><term>Parkinsonian Disorders</term><term>Synaptic Membranes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Combinations</term><term>Male</term><term>Microscopy, Immunoelectron</term><term>Oxidopamine</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa therapy in Parkinson's disease is mediated by dopamine receptors and, in a recent study, we showed that a Dl full agonist can induce an internalization of D1 dopamine receptors. The aim of the present study was to determine whether levodopa or a dopamine agonist such as ropinirole can also induce the internalization of D1 dopamine receptors in the striatum of control and hemiparkinsonian rats. The distribution of D1 dopamine receptors was analyzed by immunohistochemistry using a specific antibody. In control animals and 6-hydroxydopamine (6-OHDA)-lesioned animals treated with saline, D1 dopamine receptors were localized at the level of the plasma membrane. In contrast, in both lesioned and nonlesioned animals receiving a single dose of levodopa, but not in animals receiving ropinirole, D1 dopamine receptors were internalized in the cytoplasm. This result is likely explained by the fact that ropinirole binds to non-D1 dopamine receptors, whereas levodopa, which increases dopamine levels, indirectly acts on both D1 and D2 receptors. Ropinirole is consequently less likely to desensitize D1 dopamine receptors than levodopa and, thus, to reduce the efficacy of the treatment.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. Hirsch</name><name sortKey="Orieux, Gael" sort="Orieux, Gael" uniqKey="Orieux G" first="Gaël" last="Orieux">Gaël Orieux</name></noCountry><country name="France"><noRegion><name sortKey="Muriel, Marie Paule" sort="Muriel, Marie Paule" uniqKey="Muriel M" first="Marie-Paule" last="Muriel">Marie-Paule Muriel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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