Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm.
Identifieur interne : 000902 ( Ncbi/Checkpoint ); précédent : 000901; suivant : 000903Intracortical excitability in the hand motor representation in hand dystonia and blepharospasm.
Auteurs : Martin Sommer [Allemagne] ; Diane Ruge ; Frithjof Tergau ; Wolfgang Beuche ; Eckart Altenmüller ; Walter PaulusSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.
English descriptors
- KwdEn :
- MESH :
- instrumentation : Magnetoencephalography.
- physiology : Evoked Potentials, Motor, Neural Inhibition.
- physiopathology : Blepharospasm, Cerebral Cortex, Dystonia, Hand.
- Adult, Female, Humans, Male, Middle Aged, Time Factors.
Abstract
We sought to determine the activity of inhibiting and facilitating cortical circuits in areas surrounding a hand muscle motor representation in focal dystonia and in controls. In 15 patients with hand dystonia, 16 patients with blepharospasm, and age-matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure-eight coil over the optimal representation of the relaxed abductor digiti minimi muscle of the dominant hand. Additional conditioning stimuli were given through a second figure-eight coil that was held either above the test coil or 2 cm or 4 cm apart in the anterior, posterior, lateral, or medial direction. We measured intracortical excitability in each of the nine positions of the conditioning coil. Intracortical inhibition was reduced in both patient groups at all conditioning coil positions. With both coils centered, the intracortical facilitation did not differ between patients and controls. After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4-cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. In addition, our findings in both patient groups show a trend toward a relatively increased intracortical facilitation in surrounding motor areas.
DOI: 10.1002/mds.10205
PubMed: 12360552
Affiliations:
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Tergau</name></author><author><name sortKey="Beuche, Wolfgang" sort="Beuche, Wolfgang" uniqKey="Beuche W" first="Wolfgang" last="Beuche">Wolfgang Beuche</name></author><author><name sortKey="Altenmuller, Eckart" sort="Altenmuller, Eckart" uniqKey="Altenmuller E" first="Eckart" last="Altenmüller">Eckart Altenmüller</name></author><author><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:12360552</idno><idno type="pmid">12360552</idno><idno type="doi">10.1002/mds.10205</idno><idno type="wicri:Area/PubMed/Corpus">003949</idno><idno type="wicri:Area/PubMed/Curation">003949</idno><idno type="wicri:Area/PubMed/Checkpoint">003A57</idno><idno type="wicri:Area/Ncbi/Merge">000902</idno><idno type="wicri:Area/Ncbi/Curation">000902</idno><idno 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first="Frithjof" last="Tergau">Frithjof Tergau</name></author><author><name sortKey="Beuche, Wolfgang" sort="Beuche, Wolfgang" uniqKey="Beuche W" first="Wolfgang" last="Beuche">Wolfgang Beuche</name></author><author><name sortKey="Altenmuller, Eckart" sort="Altenmuller, Eckart" uniqKey="Altenmuller E" first="Eckart" last="Altenmüller">Eckart Altenmüller</name></author><author><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Blepharospasm (physiopathology)</term><term>Cerebral Cortex (physiopathology)</term><term>Dystonia (physiopathology)</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Hand (physiopathology)</term><term>Humans</term><term>Magnetoencephalography (instrumentation)</term><term>Male</term><term>Middle Aged</term><term>Neural Inhibition (physiology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Magnetoencephalography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Blepharospasm</term><term>Cerebral Cortex</term><term>Dystonia</term><term>Hand</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We sought to determine the activity of inhibiting and facilitating cortical circuits in areas surrounding a hand muscle motor representation in focal dystonia and in controls. In 15 patients with hand dystonia, 16 patients with blepharospasm, and age-matched controls, we applied suprathreshold transcranial magnetic stimuli with a figure-eight coil over the optimal representation of the relaxed abductor digiti minimi muscle of the dominant hand. Additional conditioning stimuli were given through a second figure-eight coil that was held either above the test coil or 2 cm or 4 cm apart in the anterior, posterior, lateral, or medial direction. We measured intracortical excitability in each of the nine positions of the conditioning coil. Intracortical inhibition was reduced in both patient groups at all conditioning coil positions. With both coils centered, the intracortical facilitation did not differ between patients and controls. After shifting the conditioning coil, the intracortical facilitation tended to be less diminished in patients than in controls, this difference between patients and controls was significant for the anterior, posterior, and medial 4-cm conditioning coil shift. Our results demonstrate decreased intracortical inhibition in the cortical hand muscle representation not only in patients with hand dystonia, but also in patients with blepharospasm. In addition, our findings in both patient groups show a trend toward a relatively increased intracortical facilitation in surrounding motor areas.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li></region><settlement><li>Göttingen</li></settlement></list><tree><noCountry><name sortKey="Altenmuller, Eckart" sort="Altenmuller, Eckart" uniqKey="Altenmuller E" first="Eckart" last="Altenmüller">Eckart Altenmüller</name><name sortKey="Beuche, Wolfgang" sort="Beuche, Wolfgang" uniqKey="Beuche W" first="Wolfgang" last="Beuche">Wolfgang Beuche</name><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name><name sortKey="Ruge, Diane" sort="Ruge, Diane" uniqKey="Ruge D" first="Diane" last="Ruge">Diane Ruge</name><name sortKey="Tergau, Frithjof" sort="Tergau, Frithjof" uniqKey="Tergau F" first="Frithjof" last="Tergau">Frithjof Tergau</name></noCountry><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Sommer, Martin" sort="Sommer, Martin" uniqKey="Sommer M" first="Martin" last="Sommer">Martin Sommer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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