[(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy.
Identifieur interne : 000609 ( Ncbi/Checkpoint ); précédent : 000608; suivant : 000610[(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy.
Auteurs : A. Varrone [États-Unis] ; K L Marek ; D. Jennings ; R B Innis ; J P SeibylSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Cocaine (analogs & derivatives), Cocaine (diagnostic use), Diagnosis, Differential, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Iodine Radioisotopes (diagnostic use), Male, Membrane Glycoproteins, Membrane Transport Proteins (deficiency), Middle Aged, Multiple System Atrophy (metabolism), Multiple System Atrophy (radionuclide imaging), Nerve Tissue Proteins, Parkinson Disease (metabolism), Parkinson Disease (radionuclide imaging), Predictive Value of Tests, Radiopharmaceuticals (diagnostic use), Severity of Illness Index, Substantia Nigra (pathology), Tomography, Emission-Computed, Single-Photon (methods).
- MESH :
- chemical , analogs & derivatives : Cocaine.
- chemical , deficiency : Membrane Transport Proteins.
- chemical , diagnostic use : Cocaine, Iodine Radioisotopes, Radiopharmaceuticals.
- metabolism : Multiple System Atrophy, Parkinson Disease.
- methods : Tomography, Emission-Computed, Single-Photon.
- pathology : Substantia Nigra.
- radionuclide imaging : Multiple System Atrophy, Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Diagnosis, Differential, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Male, Membrane Glycoproteins, Middle Aged, Nerve Tissue Proteins, Predictive Value of Tests, Severity of Illness Index.
Abstract
In vivo imaging of the dopamine transporter (DAT) with single photon emission computed tomography (SPECT) is a quantitative biomarker for Parkinson's disease (PD) onset and severity. This study has examined and compared the loss of striatal DAT in PD and multiple system atrophy (MSA) using [(123)I]beta-CIT SPECT imaging. One hundred and eighty-three patients (157 PD and 26 MSA) were studied. Clinical rating scales (Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale [UPDRS] scores) demonstrated that the MSA patients were more severely impaired than the PD patients. The striatal [(123)I]beta-CIT SPECT uptake was markedly reduced in both the PD and MSA groups. In addition, MSA patients showed more symmetric DAT loss compared with the PD patients, consistent with the more symmetric clinical motor dysfunction observed in MSA. While the loss of DAT was significantly reduced in all regions in both MSA and PD, comparison of the relative loss of the DAT did not significantly improve diagnostic accuracy in distinguishing between PD and MSA.
PubMed: 11748733
Affiliations:
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pubmed:11748733Le document en format XML
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Varrone</name><affiliation wicri:level="2"><nlm:affiliation>Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA. andreavarrone@yahho.com</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Marek, K L" sort="Marek, K L" uniqKey="Marek K" first="K L" last="Marek">K L Marek</name></author><author><name sortKey="Jennings, D" sort="Jennings, D" uniqKey="Jennings D" first="D" last="Jennings">D. Jennings</name></author><author><name sortKey="Innis, R B" sort="Innis, R B" uniqKey="Innis R" first="R B" last="Innis">R B Innis</name></author><author><name sortKey="Seibyl, J P" sort="Seibyl, J P" uniqKey="Seibyl J" first="J P" last="Seibyl">J P Seibyl</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11748733</idno><idno type="pmid">11748733</idno><idno type="wicri:Area/PubMed/Corpus">003C42</idno><idno type="wicri:Area/PubMed/Curation">003C42</idno><idno type="wicri:Area/PubMed/Checkpoint">003C09</idno><idno type="wicri:Area/Ncbi/Merge">000609</idno><idno type="wicri:Area/Ncbi/Curation">000609</idno><idno type="wicri:Area/Ncbi/Checkpoint">000609</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy.</title><author><name sortKey="Varrone, A" sort="Varrone, A" uniqKey="Varrone A" first="A" last="Varrone">A. Varrone</name><affiliation wicri:level="2"><nlm:affiliation>Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA. andreavarrone@yahho.com</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Marek, K L" sort="Marek, K L" uniqKey="Marek K" first="K L" last="Marek">K L Marek</name></author><author><name sortKey="Jennings, D" sort="Jennings, D" uniqKey="Jennings D" first="D" last="Jennings">D. Jennings</name></author><author><name sortKey="Innis, R B" sort="Innis, R B" uniqKey="Innis R" first="R B" last="Innis">R B Innis</name></author><author><name sortKey="Seibyl, J P" sort="Seibyl, J P" uniqKey="Seibyl J" first="J P" last="Seibyl">J P Seibyl</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cocaine (analogs & derivatives)</term><term>Cocaine (diagnostic use)</term><term>Diagnosis, Differential</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Humans</term><term>Iodine Radioisotopes (diagnostic use)</term><term>Male</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins (deficiency)</term><term>Middle Aged</term><term>Multiple System Atrophy (metabolism)</term><term>Multiple System Atrophy (radionuclide imaging)</term><term>Nerve Tissue Proteins</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Predictive Value of Tests</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Severity of Illness Index</term><term>Substantia Nigra (pathology)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Cocaine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Membrane Transport Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Cocaine</term><term>Iodine Radioisotopes</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Multiple System Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Diagnosis, Differential</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Humans</term><term>Male</term><term>Membrane Glycoproteins</term><term>Middle Aged</term><term>Nerve Tissue Proteins</term><term>Predictive Value of Tests</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In vivo imaging of the dopamine transporter (DAT) with single photon emission computed tomography (SPECT) is a quantitative biomarker for Parkinson's disease (PD) onset and severity. This study has examined and compared the loss of striatal DAT in PD and multiple system atrophy (MSA) using [(123)I]beta-CIT SPECT imaging. One hundred and eighty-three patients (157 PD and 26 MSA) were studied. Clinical rating scales (Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale [UPDRS] scores) demonstrated that the MSA patients were more severely impaired than the PD patients. The striatal [(123)I]beta-CIT SPECT uptake was markedly reduced in both the PD and MSA groups. In addition, MSA patients showed more symmetric DAT loss compared with the PD patients, consistent with the more symmetric clinical motor dysfunction observed in MSA. While the loss of DAT was significantly reduced in all regions in both MSA and PD, comparison of the relative loss of the DAT did not significantly improve diagnostic accuracy in distinguishing between PD and MSA.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><noCountry><name sortKey="Innis, R B" sort="Innis, R B" uniqKey="Innis R" first="R B" last="Innis">R B Innis</name><name sortKey="Jennings, D" sort="Jennings, D" uniqKey="Jennings D" first="D" last="Jennings">D. Jennings</name><name sortKey="Marek, K L" sort="Marek, K L" uniqKey="Marek K" first="K L" last="Marek">K L Marek</name><name sortKey="Seibyl, J P" sort="Seibyl, J P" uniqKey="Seibyl J" first="J P" last="Seibyl">J P Seibyl</name></noCountry><country name="États-Unis"><region name="Connecticut"><name sortKey="Varrone, A" sort="Varrone, A" uniqKey="Varrone A" first="A" last="Varrone">A. 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