Dynamic balance function in phasic cervical dystonia following Botulinum toxin therapy.
Identifieur interne : 000593 ( Ncbi/Checkpoint ); précédent : 000592; suivant : 000594Dynamic balance function in phasic cervical dystonia following Botulinum toxin therapy.
Auteurs : J. Müller [Autriche] ; G. Ebersbach ; J. Wissel ; Werner Poewe [Autriche]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- drug effects : Head Movements, Postural Balance.
- drug therapy : Torticollis.
- physiopathology : Torticollis.
- Adult, Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
Previous research by our group revealed normal dynamic balance function in pure tonic cervical dystonia (CD) with impaired equilibrium in phasic CD patients investigated at least 3 months following Botulinum toxin (BtxA) treatment. The current study was performed to determine whether impaired dynamic equilibrium in phasic CD is influenced by symptomatic treatment with BtxA. Dynamic balance was tested in 20 patients with phasic CD on a dynamic platform with a cylindrical curved base (stabilometer) 4 weeks following BtxA treatment. Balance was assessed by the linear displacement of the platform and the maximum amplitude of platform displacement with open and closed eyes and compared with pre-BtxA data. Despite a clinically significant BtxA-induced reduction of phasic head movements, none of the platform measures improved significantly. In addition, there was no correlation between the BtxA-induced clinical improvement and changes in any of the dynamic balance measures pre- vs. post-BtxA. In conclusion, the persistent dynamic balance impairment after effective BtxA therapy may indicate that disequilibrium in phasic CD does not simply reflect disturbed vestibular input from repetitive head oscillations, but argues in favour of different sensorimotor processing in tonic and phasic CD.
PubMed: 11746626
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003C58
- to stream PubMed, to step Curation: 003C58
- to stream PubMed, to step Checkpoint: 003D66
- to stream Ncbi, to step Merge: 000593
- to stream Ncbi, to step Curation: 000593
Links to Exploration step
pubmed:11746626Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dynamic balance function in phasic cervical dystonia following Botulinum toxin therapy.</title>
<author><name sortKey="Muller, J" sort="Muller, J" uniqKey="Muller J" first="J" last="Müller">J. Müller</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Innsbruck, Innsbruck, Austria. joerg.mueller@uibk.ac.at</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, University of Innsbruck, Innsbruck</wicri:regionArea>
<wicri:noRegion>Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ebersbach, G" sort="Ebersbach, G" uniqKey="Ebersbach G" first="G" last="Ebersbach">G. Ebersbach</name>
</author>
<author><name sortKey="Wissel, J" sort="Wissel, J" uniqKey="Wissel J" first="J" last="Wissel">J. Wissel</name>
</author>
<author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W" last="Poewe">Werner Poewe</name>
<affiliation><country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2001">2001</date>
<idno type="RBID">pubmed:11746626</idno>
<idno type="pmid">11746626</idno>
<idno type="wicri:Area/PubMed/Corpus">003C58</idno>
<idno type="wicri:Area/PubMed/Curation">003C58</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003D66</idno>
<idno type="wicri:Area/Ncbi/Merge">000593</idno>
<idno type="wicri:Area/Ncbi/Curation">000593</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000593</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Dynamic balance function in phasic cervical dystonia following Botulinum toxin therapy.</title>
<author><name sortKey="Muller, J" sort="Muller, J" uniqKey="Muller J" first="J" last="Müller">J. Müller</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Innsbruck, Innsbruck, Austria. joerg.mueller@uibk.ac.at</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, University of Innsbruck, Innsbruck</wicri:regionArea>
<wicri:noRegion>Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ebersbach, G" sort="Ebersbach, G" uniqKey="Ebersbach G" first="G" last="Ebersbach">G. Ebersbach</name>
</author>
<author><name sortKey="Wissel, J" sort="Wissel, J" uniqKey="Wissel J" first="J" last="Wissel">J. Wissel</name>
</author>
<author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W" last="Poewe">Werner Poewe</name>
<affiliation><country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2001" type="published">2001</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Botulinum Toxins, Type A (therapeutic use)</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Head Movements (drug effects)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuromuscular Agents (therapeutic use)</term>
<term>Postural Balance (drug effects)</term>
<term>Torticollis (drug therapy)</term>
<term>Torticollis (physiopathology)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term>
<term>Neuromuscular Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Head Movements</term>
<term>Postural Balance</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Torticollis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Torticollis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Previous research by our group revealed normal dynamic balance function in pure tonic cervical dystonia (CD) with impaired equilibrium in phasic CD patients investigated at least 3 months following Botulinum toxin (BtxA) treatment. The current study was performed to determine whether impaired dynamic equilibrium in phasic CD is influenced by symptomatic treatment with BtxA. Dynamic balance was tested in 20 patients with phasic CD on a dynamic platform with a cylindrical curved base (stabilometer) 4 weeks following BtxA treatment. Balance was assessed by the linear displacement of the platform and the maximum amplitude of platform displacement with open and closed eyes and compared with pre-BtxA data. Despite a clinically significant BtxA-induced reduction of phasic head movements, none of the platform measures improved significantly. In addition, there was no correlation between the BtxA-induced clinical improvement and changes in any of the dynamic balance measures pre- vs. post-BtxA. In conclusion, the persistent dynamic balance impairment after effective BtxA therapy may indicate that disequilibrium in phasic CD does not simply reflect disturbed vestibular input from repetitive head oscillations, but argues in favour of different sensorimotor processing in tonic and phasic CD.</div>
</front>
</TEI>
<affiliations><list><country><li>Autriche</li>
</country>
<region><li>Tyrol (Land)</li>
</region>
<settlement><li>Innsbruck</li>
</settlement>
<orgName><li>Université de médecine d'Innsbruck</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Ebersbach, G" sort="Ebersbach, G" uniqKey="Ebersbach G" first="G" last="Ebersbach">G. Ebersbach</name>
<name sortKey="Wissel, J" sort="Wissel, J" uniqKey="Wissel J" first="J" last="Wissel">J. Wissel</name>
</noCountry>
<country name="Autriche"><noRegion><name sortKey="Muller, J" sort="Muller, J" uniqKey="Muller J" first="J" last="Müller">J. Müller</name>
</noRegion>
<name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W" last="Poewe">Werner Poewe</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000593 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000593 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= pubmed:11746626 |texte= Dynamic balance function in phasic cervical dystonia following Botulinum toxin therapy. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:11746626" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
This area was generated with Dilib version V0.6.23. |