L‐dopa does not affect electron transfer chain enzymes and respiration of rat muscle mitochondria
Identifieur interne : 009458 ( Main/Merge ); précédent : 009457; suivant : 009459L‐dopa does not affect electron transfer chain enzymes and respiration of rat muscle mitochondria
Auteurs : Dagani [Italie] ; Rosaria Ferrari [Italie] ; Jeffrey J. Anderson [États-Unis] ; Thomas N. Chase [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1991.
English descriptors
- KwdEn :
- Animals, Dose-Response Relationship, Drug, Electron Transport (drug effects), Electron Transport (physiology), Electron Transport Complex IV (metabolism), Energy Metabolism (drug effects), Energy Metabolism (physiology), Enzyme activities, Glutamate Dehydrogenase (metabolism), Levodopa (pharmacology), L‐dopa, Male, Mitochondria, Muscle (drug effects), Mitochondria, Muscle (enzymology), NADH Dehydrogenase (metabolism), Rats, Rats, Inbred Strains, Respiration, Skeletal muscle mitochondria, Succinate Cytochrome c Oxidoreductase (metabolism).
- MESH :
- chemical , metabolism : Electron Transport Complex IV, Glutamate Dehydrogenase, NADH Dehydrogenase, Succinate Cytochrome c Oxidoreductase.
- drug effects : Electron Transport, Energy Metabolism, Mitochondria, Muscle.
- enzymology : Mitochondria, Muscle.
- chemical , pharmacology : Levodopa.
- physiology : Electron Transport, Energy Metabolism.
- Animals, Dose-Response Relationship, Drug, Male, Rats, Rats, Inbred Strains.
Abstract
Alterations in mitochondrial respiratory chain enzymes have been found in skeletal muscle of parkinsonian patients. Most of these patients had received treatment with L‐dopa in combination with an inhibitor of peripheral decarboxylase for several years. In order to determine whether these effects are only dependent on the disease or are partially due to its therapy, the effects of L‐dopa methyl ester and benserazide, a peripheral dopa decarboxylase inhibitor, were studied on various parameters related to energy metabolism in rat skeletal muscle mitochondria. The maximum activities related to complexes of the respiratory chain: rotenone‐sensitive NADH‐cytochrome c reductase, succinate‐cytochrome c reductase, cytochrome c oxidase, state 3, state 4, uncoupled state, and respiratory control ratio were measured after 17‐19 days of treatment. The results indicate that L‐dopa treatment does not interfere with any of the parameters investigated and suggest that changes in muscle mitochondrial function found in parkinsonian patients are the result of the disease process and not its treatment.
Url:
DOI: 10.1002/mds.870060408
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Chase</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EACA8D65C40C1DBAD899B0D39AB45CA4E85B59E0</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1002/mds.870060408</idno><idno type="url">https://api.istex.fr/document/EACA8D65C40C1DBAD899B0D39AB45CA4E85B59E0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002C12</idno><idno type="wicri:Area/Istex/Curation">002C12</idno><idno type="wicri:Area/Istex/Checkpoint">004297</idno><idno type="wicri:doubleKey">0885-3185:1991:Dagani:l:dopa:does</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:1661844</idno><idno type="wicri:Area/PubMed/Corpus">004E57</idno><idno type="wicri:Area/PubMed/Curation">004E57</idno><idno type="wicri:Area/PubMed/Checkpoint">004E17</idno><idno type="wicri:Area/Ncbi/Merge">001637</idno><idno type="wicri:Area/Ncbi/Curation">001637</idno><idno type="wicri:Area/Ncbi/Checkpoint">001637</idno><idno type="wicri:doubleKey">0885-3185:1991:Dagani F:l:dopa:does</idno><idno type="wicri:Area/Main/Merge">009458</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">L‐dopa does not affect electron transfer chain enzymes and respiration of rat muscle mitochondria</title><author><name sortKey="Dagani" sort="Dagani" uniqKey="Dagani" last="Dagani">Dagani</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Farmacologia, Facoltà di Scienze MM.FF.NN., University of Pavia</wicri:regionArea><wicri:noRegion>University of Pavia</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Current Address: Istituto di Farmacologia, Facoltà di Scienze MM.FF.NN., Università di Pavia, Piazza Botta 11, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Ferrari, Rosaria" sort="Ferrari, Rosaria" uniqKey="Ferrari R" first="Rosaria" last="Ferrari">Rosaria Ferrari</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Farmacologia, Facoltà di Scienze MM.FF.NN., University of Pavia</wicri:regionArea><wicri:noRegion>University of Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, Jeffrey J" sort="Anderson, Jeffrey J" uniqKey="Anderson J" first="Jeffrey J." last="Anderson">Jeffrey J. Anderson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chase, Thomas N" sort="Chase, Thomas N" uniqKey="Chase T" first="Thomas N." last="Chase">Thomas N. Chase</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1991">1991</date><biblScope unit="vol">6</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="315">315</biblScope><biblScope unit="page" to="319">319</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EACA8D65C40C1DBAD899B0D39AB45CA4E85B59E0</idno><idno type="DOI">10.1002/mds.870060408</idno><idno type="ArticleID">MDS870060408</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Electron Transport (drug effects)</term><term>Electron Transport (physiology)</term><term>Electron Transport Complex IV (metabolism)</term><term>Energy Metabolism (drug effects)</term><term>Energy Metabolism (physiology)</term><term>Enzyme activities</term><term>Glutamate Dehydrogenase (metabolism)</term><term>Levodopa (pharmacology)</term><term>L‐dopa</term><term>Male</term><term>Mitochondria, Muscle (drug effects)</term><term>Mitochondria, Muscle (enzymology)</term><term>NADH Dehydrogenase (metabolism)</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Respiration</term><term>Skeletal muscle mitochondria</term><term>Succinate Cytochrome c Oxidoreductase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Electron Transport Complex IV</term><term>Glutamate Dehydrogenase</term><term>NADH Dehydrogenase</term><term>Succinate Cytochrome c Oxidoreductase</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Electron Transport</term><term>Energy Metabolism</term><term>Mitochondria, Muscle</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Mitochondria, Muscle</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Electron Transport</term><term>Energy Metabolism</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Male</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alterations in mitochondrial respiratory chain enzymes have been found in skeletal muscle of parkinsonian patients. Most of these patients had received treatment with L‐dopa in combination with an inhibitor of peripheral decarboxylase for several years. In order to determine whether these effects are only dependent on the disease or are partially due to its therapy, the effects of L‐dopa methyl ester and benserazide, a peripheral dopa decarboxylase inhibitor, were studied on various parameters related to energy metabolism in rat skeletal muscle mitochondria. The maximum activities related to complexes of the respiratory chain: rotenone‐sensitive NADH‐cytochrome c reductase, succinate‐cytochrome c reductase, cytochrome c oxidase, state 3, state 4, uncoupled state, and respiratory control ratio were measured after 17‐19 days of treatment. The results indicate that L‐dopa treatment does not interfere with any of the parameters investigated and suggest that changes in muscle mitochondrial function found in parkinsonian patients are the result of the disease process and not its treatment.</div></front></TEI><double doi="10.1002/mds.870060408"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">L‐dopa does not affect electron transfer chain enzymes and respiration of rat muscle mitochondria</title><author><name sortKey="Dagani" sort="Dagani" uniqKey="Dagani" last="Dagani">Dagani</name></author><author><name sortKey="Ferrari, Rosaria" sort="Ferrari, Rosaria" uniqKey="Ferrari R" first="Rosaria" last="Ferrari">Rosaria Ferrari</name></author><author><name sortKey="Anderson, Jeffrey J" sort="Anderson, Jeffrey J" uniqKey="Anderson J" first="Jeffrey J." last="Anderson">Jeffrey J. Anderson</name></author><author><name sortKey="Chase, Thomas N" sort="Chase, Thomas N" uniqKey="Chase T" first="Thomas N." last="Chase">Thomas N. Chase</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EACA8D65C40C1DBAD899B0D39AB45CA4E85B59E0</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1002/mds.870060408</idno><idno type="url">https://api.istex.fr/document/EACA8D65C40C1DBAD899B0D39AB45CA4E85B59E0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002C12</idno><idno type="wicri:Area/Istex/Curation">002C12</idno><idno type="wicri:Area/Istex/Checkpoint">004297</idno><idno type="wicri:doubleKey">0885-3185:1991:Dagani:l:dopa:does</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">L‐dopa does not affect electron transfer chain enzymes and respiration of rat muscle mitochondria</title><author><name sortKey="Dagani" sort="Dagani" uniqKey="Dagani" last="Dagani">Dagani</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Farmacologia, Facoltà di Scienze MM.FF.NN., University of Pavia</wicri:regionArea><wicri:noRegion>University of Pavia</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Current Address: Istituto di Farmacologia, Facoltà di Scienze MM.FF.NN., Università di Pavia, Piazza Botta 11, 27100 Pavia</wicri:regionArea><wicri:noRegion>27100 Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Ferrari, Rosaria" sort="Ferrari, Rosaria" uniqKey="Ferrari R" first="Rosaria" last="Ferrari">Rosaria Ferrari</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Farmacologia, Facoltà di Scienze MM.FF.NN., University of Pavia</wicri:regionArea><wicri:noRegion>University of Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, Jeffrey J" sort="Anderson, Jeffrey J" uniqKey="Anderson J" first="Jeffrey J." last="Anderson">Jeffrey J. Anderson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Chase, Thomas N" sort="Chase, Thomas N" uniqKey="Chase T" first="Thomas N." last="Chase">Thomas N. Chase</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1991">1991</date><biblScope unit="vol">6</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="315">315</biblScope><biblScope unit="page" to="319">319</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">EACA8D65C40C1DBAD899B0D39AB45CA4E85B59E0</idno><idno type="DOI">10.1002/mds.870060408</idno><idno type="ArticleID">MDS870060408</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Enzyme activities</term><term>L‐dopa</term><term>Respiration</term><term>Skeletal muscle mitochondria</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alterations in mitochondrial respiratory chain enzymes have been found in skeletal muscle of parkinsonian patients. Most of these patients had received treatment with L‐dopa in combination with an inhibitor of peripheral decarboxylase for several years. In order to determine whether these effects are only dependent on the disease or are partially due to its therapy, the effects of L‐dopa methyl ester and benserazide, a peripheral dopa decarboxylase inhibitor, were studied on various parameters related to energy metabolism in rat skeletal muscle mitochondria. The maximum activities related to complexes of the respiratory chain: rotenone‐sensitive NADH‐cytochrome c reductase, succinate‐cytochrome c reductase, cytochrome c oxidase, state 3, state 4, uncoupled state, and respiratory control ratio were measured after 17‐19 days of treatment. The results indicate that L‐dopa treatment does not interfere with any of the parameters investigated and suggest that changes in muscle mitochondrial function found in parkinsonian patients are the result of the disease process and not its treatment.</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">L-dopa does not affect electron transfer chain enzymes and respiration of rat muscle mitochondria.</title><author><name sortKey="Dagani, F" sort="Dagani, F" uniqKey="Dagani F" first="F" last="Dagani">F. Dagani</name><affiliation wicri:level="1"><nlm:affiliation>Istituto di Farmacologia, Facoltà di Scienze MM.FF.NN., University of Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Farmacologia, Facoltà di Scienze MM.FF.NN., University of Pavia</wicri:regionArea><wicri:noRegion>University of Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Ferrari, R" sort="Ferrari, R" uniqKey="Ferrari R" first="R" last="Ferrari">R. Ferrari</name></author><author><name sortKey="Anderson, J J" sort="Anderson, J J" uniqKey="Anderson J" first="J J" last="Anderson">J J Anderson</name></author><author><name sortKey="Chase, T N" sort="Chase, T N" uniqKey="Chase T" first="T N" last="Chase">T N Chase</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1661844</idno><idno type="pmid">1661844</idno><idno type="doi">10.1002/mds.870060408</idno><idno type="wicri:Area/PubMed/Corpus">004E57</idno><idno type="wicri:Area/PubMed/Curation">004E57</idno><idno type="wicri:Area/PubMed/Checkpoint">004E17</idno><idno type="wicri:Area/Ncbi/Merge">001637</idno><idno type="wicri:Area/Ncbi/Curation">001637</idno><idno type="wicri:Area/Ncbi/Checkpoint">001637</idno><idno type="wicri:doubleKey">0885-3185:1991:Dagani F:l:dopa:does</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">L-dopa does not affect electron transfer chain enzymes and respiration of rat muscle mitochondria.</title><author><name sortKey="Dagani, F" sort="Dagani, F" uniqKey="Dagani F" first="F" last="Dagani">F. Dagani</name><affiliation wicri:level="1"><nlm:affiliation>Istituto di Farmacologia, Facoltà di Scienze MM.FF.NN., University of Pavia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Farmacologia, Facoltà di Scienze MM.FF.NN., University of Pavia</wicri:regionArea><wicri:noRegion>University of Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Ferrari, R" sort="Ferrari, R" uniqKey="Ferrari R" first="R" last="Ferrari">R. Ferrari</name></author><author><name sortKey="Anderson, J J" sort="Anderson, J J" uniqKey="Anderson J" first="J J" last="Anderson">J J Anderson</name></author><author><name sortKey="Chase, T N" sort="Chase, T N" uniqKey="Chase T" first="T N" last="Chase">T N Chase</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Electron Transport (drug effects)</term><term>Electron Transport (physiology)</term><term>Electron Transport Complex IV (metabolism)</term><term>Energy Metabolism (drug effects)</term><term>Energy Metabolism (physiology)</term><term>Glutamate Dehydrogenase (metabolism)</term><term>Levodopa (pharmacology)</term><term>Male</term><term>Mitochondria, Muscle (drug effects)</term><term>Mitochondria, Muscle (enzymology)</term><term>NADH Dehydrogenase (metabolism)</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Succinate Cytochrome c Oxidoreductase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Electron Transport Complex IV</term><term>Glutamate Dehydrogenase</term><term>NADH Dehydrogenase</term><term>Succinate Cytochrome c Oxidoreductase</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Electron Transport</term><term>Energy Metabolism</term><term>Mitochondria, Muscle</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Mitochondria, Muscle</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Electron Transport</term><term>Energy Metabolism</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Male</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alterations in mitochondrial respiratory chain enzymes have been found in skeletal muscle of parkinsonian patients. Most of these patients had received treatment with L-dopa in combination with an inhibitor of peripheral decarboxylase for several years. In order to determine whether these effects are only dependent on the disease or are partially due to its therapy, the effects of L-dopa methyl ester and benserazide, a peripheral dopa decarboxylase inhibitor, were studied on various parameters related to energy metabolism in rat skeletal muscle mitochondria. The maximum activities related to complexes of the respiratory chain: rotenone-sensitive NADH-cytochrome c reductase, succinate-cytochrome c reductase, cytochrome c oxidase, state 3, state 4, uncoupled state, and respiratory control ratio were measured after 17-19 days of treatment. The results indicate that L-dopa treatment does not interfere with any of the parameters investigated and suggest that changes in muscle mitochondrial function found in parkinsonian patients are the result of the disease process and not its treatment.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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