Movement Disorders (revue)

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Unified Parkinson's disease rating scale characteristics and structure

Identifieur interne : 008C64 ( Main/Merge ); précédent : 008C63; suivant : 008C65

Unified Parkinson's disease rating scale characteristics and structure

Auteurs : Martínez‐Martín [Espagne] ; A. Gil-Nagel [Espagne] ; L. Morlán Gracia [Espagne] ; J. Balseiro G Mez [Espagne] ; J. Martínez-Sarriés [Espagne] ; F. Bermejo [Espagne]

Source :

RBID : ISTEX:05213D6C7BD93822DA67F9C299D595D693B5838B

English descriptors

Abstract

Our purpose was to verify some basic aspects of validation of the Unified Parkinson's Disease Rating Scale (UPDRS). One hundred and sixtyseven Parkinson's disease (PD) patients were included. Group A (n=40) was simultaneously assessed by five raters who applied the UPDRS and other PD rating scales (PDRS). A set of timed tests, the Mini‐Mental State Examination (MMSE), and the Hamilton Scale for Depression (HSD) were administered by an independent examiner. Group B (n = 127) was individually assessed through the UPDRS and the other PDRSs by one neurologist in four different hospitals. The UPDRS was administered in 16.95 ± 7.98 min. The internal consistency was high (Cronbach's alpha = 0.96). Nevertheless, the items related to depression, motivation/initiative, and tremor were scarcely consistent. The Interrater reliability was satisfactory (all the items had k > 0.40). There was a high correlation of the UPDRS with the Hoehn and Yahr staging (rs = 0.71; p < 0.001) and some timed tests (finger tapping; arising from chair), but also with the MMSE and HSD (rs = 0.53; rs = 0.64; p < 0.001). The convergent validity with the other PDRS (Intermediate Scale and Schwab and England Scale) was very high (rs = 0.76−0.96; p < 0.001). The factor analysis identified six factors that explained 59.6% of the variance. The dimension “tremor” showed a remarkable independence. The UPDRS is a multidimensional, reliable, and valid scale, with some inconveniences derived from its internal consistency, discriminant validity, and pragmatic application.

Url:
DOI: 10.1002/mds.870090112

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ISTEX:05213D6C7BD93822DA67F9C299D595D693B5838B

Le document en format XML

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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Section of Neurology, Hospital Universitario de Getafe, Universidad Complutense, Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gil Nagel, A" sort="Gil Nagel, A" uniqKey="Gil Nagel A" first="A" last="Gil-Nagel">A. Gil-Nagel</name>
</author>
<author>
<name sortKey="Gracia, L M" sort="Gracia, L M" uniqKey="Gracia L" first="L M" last="Gracia">L M Gracia</name>
</author>
<author>
<name sortKey="G Mez, J B" sort="G Mez, J B" uniqKey="G Mez J" first="J B" last="G Mez">J B G Mez</name>
</author>
<author>
<name sortKey="Martinez Sarries, J" sort="Martinez Sarries, J" uniqKey="Martinez Sarries J" first="J" last="Martínez-Sarriés">J. Martínez-Sarriés</name>
</author>
<author>
<name sortKey="Bermejo, F" sort="Bermejo, F" uniqKey="Bermejo F" first="F" last="Bermejo">F. Bermejo</name>
</author>
</analytic>
<series>
<title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint>
<date when="1994" type="published">1994</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Activities of Daily Living (classification)</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Factor Analysis, Statistical</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Status Schedule (statistics & numerical data)</term>
<term>Middle Aged</term>
<term>Neurologic Examination (classification)</term>
<term>Neurologic Examination (statistics & numerical data)</term>
<term>Observer Variation</term>
<term>Parkinson Disease (classification)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Personality Inventory (statistics & numerical data)</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en">
<term>Activities of Daily Living</term>
<term>Neurologic Examination</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en">
<term>Mental Status Schedule</term>
<term>Neurologic Examination</term>
<term>Personality Inventory</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Factor Analysis, Statistical</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Observer Variation</term>
<term>Reproducibility of Results</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Our purpose was to verify some basic aspects of validation of the Unified Parkinson's Disease Rating Scale (UPDRS). One hundred and sixty-seven Parkinson's disease (PD) patients were included. Group A (n = 40) was simultaneously assessed by five raters who applied the UPDRS and other PD rating scales (PDRS). A set of timed tests, the Mini-Mental State Examination (MMSE), and the Hamilton Scale for Depression (HSD) were administered by an independent examiner. Group B (n = 127) was individually assessed through the UPDRS and the other PDRSs by one neurologist in four different hospitals. The UPDRS was administered in 16.95 +/- 7.98 min. The internal consistency was high (Cronbach's alpha = 0.96). Nevertheless, the items related to depression, motivation/initiative, and tremor were scarcely consistent. The Interrater reliability was satisfactory (all the items had k > 0.40). There was a high correlation of the UPDRS with the Hoehn and Yahr staging (rs = 0.71; p < 0.001) and some timed tests (finger tapping; arising from chair), but also with the MMSE and HSD (rs = 0.53; rs = 0.64; p < 0.001). The convergent validity with the other PDRS (Intermediate Scale and Schwab and England Scale) was very high (rs = 0.76-0.96; p < 0.001). The factor analysis identified six factors that explained 59.6% of the variance. The dimension "tremor" showed a remarkable independence. The UPDRS is a multidimensional, reliable, and valid scale, with some inconveniences derived from its internal consistency, discriminant validity, and pragmatic application.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

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