Frontal and parietal premovement slow brain potentials in Parkinson's disease and aging
Identifieur interne : 008A63 ( Main/Merge ); précédent : 008A62; suivant : 008A64Frontal and parietal premovement slow brain potentials in Parkinson's disease and aging
Auteurs : Bötzel [Allemagne] ; M. Mayer [Allemagne] ; W. H. Oertel [Allemagne] ; W. Paulus [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 1995-01.
English descriptors
- KwdEn :
- Age Factors, Aged, Aging (physiology), Contingent negative variation, Electrophysiology, Evoked Potentials, Female, Frontal Lobe (physiology), Frontal Lobe (physiopathology), Humans, Male, Middle Aged, Motor‐evoked potential, Parietal Lobe (physiology), Parietal Lobe (physiopathology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson's disease, Reaction Time (physiology).
- MESH :
- diagnosis : Parkinson Disease.
- physiology : Aging, Frontal Lobe, Parietal Lobe, Reaction Time.
- physiopathology : Frontal Lobe, Parietal Lobe, Parkinson Disease.
- Age Factors, Aged, Electrophysiology, Evoked Potentials, Female, Humans, Male, Middle Aged.
Abstract
During the anticipation of a stimulus that induces a predetermined pattern of behavior, a slowly increasing negative electric potential can be recorded from the human scalp at central and parietal electrodes and has been named contingent negative variation (CNV). We used a simple and a choice reaction time paradigm to investigate premovement potentials in patients with Parkinson's disease (PD) and in normal controls. There was a clear CNV in young subjects whereas it was negligible in the elderly control subjects and absent in the patients. In addition, we found a slowly increasing positive frontal potential. In normals the steepness of this potential decreased with the complexity of the task (simple vs. choice) and with age. This difference was abolished in the patients: If a slowly increasing positivity was observed at all, it was, on average, larger in the choice task. Reaction times of the patients were disproportionally prolonged in the simple compared to the complex task. These findings support the hypothesis that storing or initiating a simple preprogrammed motor response is more impaired in PD than selecting and initiating a motor response of a more complex task. The electrophysiological recordings suggest that impaired activation of the frontal lobes may be responsible for this deficit.
Url:
DOI: 10.1002/mds.870100114
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Paulus</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Clinical Neurophysiology, University of Göttingen</wicri:regionArea><wicri:noRegion>University of Göttingen</wicri:noRegion><wicri:noRegion>University of Göttingen</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1995-01">1995-01</date><biblScope unit="vol">10</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="85">85</biblScope><biblScope unit="page" to="91">91</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">16513D2D2005C857E01285CA3C7080E8AD837518</idno><idno type="DOI">10.1002/mds.870100114</idno><idno type="ArticleID">MDS870100114</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aging (physiology)</term><term>Contingent negative variation</term><term>Electrophysiology</term><term>Evoked Potentials</term><term>Female</term><term>Frontal Lobe (physiology)</term><term>Frontal Lobe (physiopathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor‐evoked potential</term><term>Parietal Lobe (physiology)</term><term>Parietal Lobe (physiopathology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson's disease</term><term>Reaction Time (physiology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term><term>Frontal Lobe</term><term>Parietal Lobe</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Frontal Lobe</term><term>Parietal Lobe</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Electrophysiology</term><term>Evoked Potentials</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the anticipation of a stimulus that induces a predetermined pattern of behavior, a slowly increasing negative electric potential can be recorded from the human scalp at central and parietal electrodes and has been named contingent negative variation (CNV). We used a simple and a choice reaction time paradigm to investigate premovement potentials in patients with Parkinson's disease (PD) and in normal controls. There was a clear CNV in young subjects whereas it was negligible in the elderly control subjects and absent in the patients. In addition, we found a slowly increasing positive frontal potential. In normals the steepness of this potential decreased with the complexity of the task (simple vs. choice) and with age. This difference was abolished in the patients: If a slowly increasing positivity was observed at all, it was, on average, larger in the choice task. Reaction times of the patients were disproportionally prolonged in the simple compared to the complex task. These findings support the hypothesis that storing or initiating a simple preprogrammed motor response is more impaired in PD than selecting and initiating a motor response of a more complex task. The electrophysiological recordings suggest that impaired activation of the frontal lobes may be responsible for this deficit.</div></front></TEI><double doi="10.1002/mds.870100114"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Frontal and parietal premovement slow brain potentials in Parkinson's disease and aging</title><author><name sortKey="Botzel" sort="Botzel" uniqKey="Botzel" last="Bötzel">Bötzel</name></author><author><name sortKey="Mayer, M" sort="Mayer, M" uniqKey="Mayer M" first="M." last="Mayer">M. Mayer</name></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W. H." last="Oertel">W. H. Oertel</name></author><author><name sortKey="Paulus, W" sort="Paulus, W" uniqKey="Paulus W" first="W." last="Paulus">W. 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Mayer</name><affiliation wicri:level="3"><country>Allemagne</country><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><wicri:orgArea>Department of Neurology, Ludwig‐Maximilians‐University</wicri:orgArea></affiliation></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W. H." last="Oertel">W. H. Oertel</name><affiliation wicri:level="3"><country>Allemagne</country><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><wicri:orgArea>Department of Neurology, Ludwig‐Maximilians‐University</wicri:orgArea></affiliation></author><author><name sortKey="Paulus, W" sort="Paulus, W" uniqKey="Paulus W" first="W." last="Paulus">W. Paulus</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Clinical Neurophysiology, University of Göttingen</wicri:regionArea><wicri:noRegion>University of Göttingen</wicri:noRegion><wicri:noRegion>University of Göttingen</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1995-01">1995-01</date><biblScope unit="vol">10</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="85">85</biblScope><biblScope unit="page" to="91">91</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">16513D2D2005C857E01285CA3C7080E8AD837518</idno><idno type="DOI">10.1002/mds.870100114</idno><idno type="ArticleID">MDS870100114</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Contingent negative variation</term><term>Motor‐evoked potential</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the anticipation of a stimulus that induces a predetermined pattern of behavior, a slowly increasing negative electric potential can be recorded from the human scalp at central and parietal electrodes and has been named contingent negative variation (CNV). We used a simple and a choice reaction time paradigm to investigate premovement potentials in patients with Parkinson's disease (PD) and in normal controls. There was a clear CNV in young subjects whereas it was negligible in the elderly control subjects and absent in the patients. In addition, we found a slowly increasing positive frontal potential. In normals the steepness of this potential decreased with the complexity of the task (simple vs. choice) and with age. This difference was abolished in the patients: If a slowly increasing positivity was observed at all, it was, on average, larger in the choice task. Reaction times of the patients were disproportionally prolonged in the simple compared to the complex task. These findings support the hypothesis that storing or initiating a simple preprogrammed motor response is more impaired in PD than selecting and initiating a motor response of a more complex task. The electrophysiological recordings suggest that impaired activation of the frontal lobes may be responsible for this deficit.</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Frontal and parietal premovement slow brain potentials in Parkinson's disease and aging.</title><author><name sortKey="Botzel, K" sort="Botzel, K" uniqKey="Botzel K" first="K" last="Bötzel">K. Bötzel</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Ludwig-Maximilians-University, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ludwig-Maximilians-University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Mayer, M" sort="Mayer, M" uniqKey="Mayer M" first="M" last="Mayer">M. Mayer</name></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name></author><author><name sortKey="Paulus, W" sort="Paulus, W" uniqKey="Paulus W" first="W" last="Paulus">W. Paulus</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1995">1995</date><idno type="RBID">pubmed:7885360</idno><idno type="pmid">7885360</idno><idno type="doi">10.1002/mds.870100114</idno><idno type="wicri:Area/PubMed/Corpus">004A21</idno><idno type="wicri:Area/PubMed/Curation">004A21</idno><idno type="wicri:Area/PubMed/Checkpoint">004981</idno><idno type="wicri:Area/Ncbi/Merge">004802</idno><idno type="wicri:Area/Ncbi/Curation">004802</idno><idno type="wicri:Area/Ncbi/Checkpoint">004802</idno><idno type="wicri:doubleKey">0885-3185:1995:Botzel K:frontal:and:parietal</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Frontal and parietal premovement slow brain potentials in Parkinson's disease and aging.</title><author><name sortKey="Botzel, K" sort="Botzel, K" uniqKey="Botzel K" first="K" last="Bötzel">K. Bötzel</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Ludwig-Maximilians-University, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ludwig-Maximilians-University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Mayer, M" sort="Mayer, M" uniqKey="Mayer M" first="M" last="Mayer">M. Mayer</name></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name></author><author><name sortKey="Paulus, W" sort="Paulus, W" uniqKey="Paulus W" first="W" last="Paulus">W. Paulus</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aging (physiology)</term><term>Electrophysiology</term><term>Evoked Potentials</term><term>Female</term><term>Frontal Lobe (physiology)</term><term>Frontal Lobe (physiopathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parietal Lobe (physiology)</term><term>Parietal Lobe (physiopathology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Reaction Time (physiology)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term><term>Frontal Lobe</term><term>Parietal Lobe</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Frontal Lobe</term><term>Parietal Lobe</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Electrophysiology</term><term>Evoked Potentials</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the anticipation of a stimulus that induces a predetermined pattern of behavior, a slowly increasing negative electric potential can be recorded from the human scalp at central and parietal electrodes and has been named contingent negative variation (CNV). We used a simple and a choice reaction time paradigm to investigate premovement potentials in patients with Parkinson's disease (PD) and in normal controls. There was a clear CNV in young subjects whereas it was negligible in the elderly control subjects and absent in the patients. In addition, we found a slowly increasing positive frontal potential. In normals the steepness of this potential decreased with the complexity of the task (simple vs. choice) and with age. This difference was abolished in the patients: If a slowly increasing positivity was observed at all, it was, on average, larger in the choice task. Reaction times of the patients were disproportionally prolonged in the simple compared to the complex task. These findings support the hypothesis that storing or initiating a simple preprogrammed motor response is more impaired in PD than selecting and initiating a motor response of a more complex task. The electrophysiological recordings suggest that impaired activation of the frontal lobes may be responsible for this deficit.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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