MovDisordV3, Main, Merge, bibRecord, 008011

123I‐β‐CIT and 123I‐IBZM‐SPECT scanning in levodopa‐naive Parkinson's disease

Identifieur interne : 008011 ( Main/Merge ); précédent : 008010; suivant : 008012

123I‐β‐CIT and 123I‐IBZM‐SPECT scanning in levodopa‐naive Parkinson's disease

Auteurs : Wenning [Autriche] ; Eveline Donnemiller [Autriche] ; Roberta Granata [Autriche] ; Georg Riccabona [Autriche] ; Werner Poewe [Autriche]

Source :

Movement Disorders [ 0885-3185 ] ; 1998-05.

RBID : ISTEX:54B5ADBC320F5D46B6105637C8FE732B03C96083

English descriptors

KwdEn :
- Aged, Benzamides (diagnostic use), Carrier Proteins (physiology), Cerebellum (physiopathology), Cerebellum (radionuclide imaging), Cocaine (analogs & derivatives), Cocaine (diagnostic use), Corpus Striatum (physiopathology), Corpus Striatum (radionuclide imaging), Dopamine Plasma Membrane Transport Proteins, Dopamine receptors, Female, Humans, IBZM, Iodine Radioisotopes (diagnostic use), Male, Membrane Glycoproteins, Membrane Transport Proteins, Middle Aged, Nerve Tissue Proteins, Parkinson Disease (physiopathology), Parkinson Disease (radionuclide imaging), Parkinson's disease, Pyrrolidines (diagnostic use), Receptors, Dopamine D2 (physiology), SPECT imaging, Tomography, Emission-Computed, Single-Photon, β‐CIT.
MESH :
- chemical , analogs & derivatives : Cocaine.
- chemical , diagnostic use : Benzamides, Cocaine, Iodine Radioisotopes, Pyrrolidines.
- chemical , physiology : Carrier Proteins, Receptors, Dopamine D2.
- physiopathology : Cerebellum, Corpus Striatum, Parkinson Disease.
- radionuclide imaging : Cerebellum, Corpus Striatum, Parkinson Disease.
- Aged, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Male, Membrane Glycoproteins, Membrane Transport Proteins, Middle Aged, Nerve Tissue Proteins, Tomography, Emission-Computed, Single-Photon.

Abstract

Striatal dopamine transporter function and dopamine D2 receptor status were evaluated in 15 patients with early untreated Parkinson's disease using single photon emission tomography (SPECT) with 123I‐Iodo‐2β‐carboxymethoxy‐3β‐(4‐idiophenyl)tropane (β‐CIT) and 123I‐Iodobenzamide (IBZM) as pre‐ and postsynaptic ligands. Symptoms were unilateral in five patients and bilateral but asymmetric in 10 patients. Patients with bilateral symptoms had significantly lower 18‐hour striatal/cerebellar β‐CIT binding ratios (3.59 ± 0.79) than hemiparkinsonian patients (5.76 ± 1.48, p < 0.05) reflecting more advanced disease in this subgroup. Patients with bilateral parkinsonism were also found to have a significant side‐to‐side difference in striatal β‐CIT binding with more marked reduction contralateral to the presenting limb (18‐hour striatal/cerebellar ratio: 4.13 ± 0.78 [ipsilateral] versus 3.59 ± 0.79 [contralateral], p < 0.05). Dopamine D2 receptor binding as measured by IBZM was significantly elevated contralateral to the affected side in hemiparkinsonian patients (striatal/cerebellar ratio: 2.42 ± 0.90 [contralateral] versus 2.19 ± 0.80 [ipsilateral], p < 0.05). This asymmetric upregulation was absent in the patients with bilateral parkinsonism (striatal/cerebellar ratio: 1.85 ± 0.43 [contralateral to more severely affected side] versus 1.83 ± 0.34 [ipsilateral], p > 0.05). Our data suggest that postsynaptic dopamine receptor upregulation contralateral to the presenting side occurs in untreated unilateral PD and disappears in untreated bilateral (asymmetric) PD despite a greater loss of dopamine transporter function. Combined β‐CIT and IBZM SPECT studies may be helpful to monitor the progression of nigrostriatal dysfunction in early PD.

Url:

https://api.istex.fr/document/54B5ADBC320F5D46B6105637C8FE732B03C96083/fulltext/pdf

DOI: 10.1002/mds.870130311

Links to Exploration step

ISTEX:54B5ADBC320F5D46B6105637C8FE732B03C96083

Le document en format XML

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<front><div type="abstract" xml:lang="en">Striatal dopamine transporter function and dopamine D2 receptor status were evaluated in 15 patients with early untreated Parkinson's disease using single photon emission tomography (SPECT) with 123I‐Iodo‐2β‐carboxymethoxy‐3β‐(4‐idiophenyl)tropane (β‐CIT) and 123I‐Iodobenzamide (IBZM) as pre‐ and postsynaptic ligands. Symptoms were unilateral in five patients and bilateral but asymmetric in 10 patients. Patients with bilateral symptoms had significantly lower 18‐hour striatal/cerebellar β‐CIT binding ratios (3.59 ± 0.79) than hemiparkinsonian patients (5.76 ± 1.48, p < 0.05) reflecting more advanced disease in this subgroup. Patients with bilateral parkinsonism were also found to have a significant side‐to‐side difference in striatal β‐CIT binding with more marked reduction contralateral to the presenting limb (18‐hour striatal/cerebellar ratio: 4.13 ± 0.78 [ipsilateral] versus 3.59 ± 0.79 [contralateral], p < 0.05). Dopamine D2 receptor binding as measured by IBZM was significantly elevated contralateral to the affected side in hemiparkinsonian patients (striatal/cerebellar ratio: 2.42 ± 0.90 [contralateral] versus 2.19 ± 0.80 [ipsilateral], p < 0.05). This asymmetric upregulation was absent in the patients with bilateral parkinsonism (striatal/cerebellar ratio: 1.85 ± 0.43 [contralateral to more severely affected side] versus 1.83 ± 0.34 [ipsilateral], p > 0.05). Our data suggest that postsynaptic dopamine receptor upregulation contralateral to the presenting side occurs in untreated unilateral PD and disappears in untreated bilateral (asymmetric) PD despite a greater loss of dopamine transporter function. Combined β‐CIT and IBZM SPECT studies may be helpful to monitor the progression of nigrostriatal dysfunction in early PD.</div>
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<front><div type="abstract" xml:lang="en">Striatal dopamine transporter function and dopamine D2 receptor status were evaluated in 15 patients with early untreated Parkinson's disease using single photon emission tomography (SPECT) with 123I‐Iodo‐2β‐carboxymethoxy‐3β‐(4‐idiophenyl)tropane (β‐CIT) and 123I‐Iodobenzamide (IBZM) as pre‐ and postsynaptic ligands. Symptoms were unilateral in five patients and bilateral but asymmetric in 10 patients. Patients with bilateral symptoms had significantly lower 18‐hour striatal/cerebellar β‐CIT binding ratios (3.59 ± 0.79) than hemiparkinsonian patients (5.76 ± 1.48, p < 0.05) reflecting more advanced disease in this subgroup. Patients with bilateral parkinsonism were also found to have a significant side‐to‐side difference in striatal β‐CIT binding with more marked reduction contralateral to the presenting limb (18‐hour striatal/cerebellar ratio: 4.13 ± 0.78 [ipsilateral] versus 3.59 ± 0.79 [contralateral], p < 0.05). Dopamine D2 receptor binding as measured by IBZM was significantly elevated contralateral to the affected side in hemiparkinsonian patients (striatal/cerebellar ratio: 2.42 ± 0.90 [contralateral] versus 2.19 ± 0.80 [ipsilateral], p < 0.05). This asymmetric upregulation was absent in the patients with bilateral parkinsonism (striatal/cerebellar ratio: 1.85 ± 0.43 [contralateral to more severely affected side] versus 1.83 ± 0.34 [ipsilateral], p > 0.05). Our data suggest that postsynaptic dopamine receptor upregulation contralateral to the presenting side occurs in untreated unilateral PD and disappears in untreated bilateral (asymmetric) PD despite a greater loss of dopamine transporter function. Combined β‐CIT and IBZM SPECT studies may be helpful to monitor the progression of nigrostriatal dysfunction in early PD.</div>
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</author>
<author><name sortKey="Donnemiller, E" sort="Donnemiller, E" uniqKey="Donnemiller E" first="E" last="Donnemiller">E. Donnemiller</name>
</author>
<author><name sortKey="Granata, R" sort="Granata, R" uniqKey="Granata R" first="R" last="Granata">R. Granata</name>
</author>
<author><name sortKey="Riccabona, G" sort="Riccabona, G" uniqKey="Riccabona G" first="G" last="Riccabona">G. Riccabona</name>
</author>
<author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W" last="Poewe">Werner Poewe</name>
<affiliation><country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="1998" type="published">1998</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Benzamides (diagnostic use)</term>
<term>Carrier Proteins (physiology)</term>
<term>Cerebellum (physiopathology)</term>
<term>Cerebellum (radionuclide imaging)</term>
<term>Cocaine (analogs & derivatives)</term>
<term>Cocaine (diagnostic use)</term>
<term>Corpus Striatum (physiopathology)</term>
<term>Corpus Striatum (radionuclide imaging)</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Female</term>
<term>Humans</term>
<term>Iodine Radioisotopes (diagnostic use)</term>
<term>Male</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Pyrrolidines (diagnostic use)</term>
<term>Receptors, Dopamine D2 (physiology)</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Cocaine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Benzamides</term>
<term>Cocaine</term>
<term>Iodine Radioisotopes</term>
<term>Pyrrolidines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Carrier Proteins</term>
<term>Receptors, Dopamine D2</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellum</term>
<term>Corpus Striatum</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cerebellum</term>
<term>Corpus Striatum</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Middle Aged</term>
<term>Nerve Tissue Proteins</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Striatal dopamine transporter function and dopamine D2 receptor status were evaluated in 15 patients with early untreated Parkinson's disease using single photon emission tomography (SPECT) with 123I-Iodo-2beta-carboxymethoxy-3beta-(4-idiophenyl)tropane (beta-CIT) and 123I-Iodobenzamide (IBZM) as pre- and postsynaptic ligands. Symptoms were unilateral in five patients and bilateral but asymmetric in 10 patients. Patients with bilateral symptoms had significantly lower 18-hour striatal/cerebellar beta-CIT binding ratios (3.59 +/- 0.79) than hemiparkinsonian patients (5.76 +/- 1.48, p < 0.05) reflecting more advanced disease in this subgroup. Patients with bilateral parkinsonism were also found to have a significant side-to-side difference in striatal beta-CIT binding with more marked reduction contralateral to the presenting limb (18-hour striatal/cerebellar ratio: 4.13 +/- 0.78 [ipsilateral] versus 3.59 +/- 0.79 [contralateral], p < 0.05). Dopamine D2 receptor binding as measured by IBZM was significantly elevated contralateral to the affected side in hemiparkinsonian patients (striatal/cerebellar ratio: 2.42 +/- 0.90 [contralateral] versus 2.19 +/- 0.80 [ipsilateral], p < 0.05). This asymmetric upregulation was absent in the patients with bilateral parkinsonism (striatal/cerebellar ratio: 1.85 +/- 0.43 [contralateral to more severely affected side] versus 1.83 +/- 0.34 [ipsilateral], p > 0.05). Our data suggest that postsynaptic dopamine receptor upregulation contralateral to the presenting side occurs in untreated unilateral PD and disappears in untreated bilateral (asymmetric) PD despite a greater loss of dopamine transporter function. Combined beta-CIT and IBZM SPECT studies may be helpful to monitor the progression of nigrostriatal dysfunction in early PD.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

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Movement Disorders (revue)

123I‐β‐CIT and 123I‐IBZM‐SPECT scanning in levodopa‐naive Parkinson's disease

123I‐β‐CIT and 123I‐IBZM‐SPECT scanning in levodopa‐naive Parkinson's disease

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