Progression of falls in postmortem-confirmed parkinsonian disorders.
Identifieur interne : 007733 ( Main/Merge ); précédent : 007732; suivant : 007734Progression of falls in postmortem-confirmed parkinsonian disorders.
Auteurs : G K Wenning [Autriche] ; G. Ebersbach ; M. Verny ; K R Chaudhuri ; K. Jellinger ; A. Mckee ; Werner Poewe [Autriche] ; I. LitvanSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1999.
English descriptors
- KwdEn :
- Accidental Falls (statistics & numerical data), Adult, Aged, Aged, 80 and over, Brain (pathology), Disease Progression, Female, Gait, Humans, Lewy Body Disease (mortality), Lewy Body Disease (pathology), Male, Middle Aged, Multiple System Atrophy (mortality), Multiple System Atrophy (pathology), Neurologic Examination, Parkinson Disease (mortality), Parkinson Disease (pathology), Parkinsonian Disorders (mortality), Parkinsonian Disorders (pathology), Recurrence, Supranuclear Palsy, Progressive (mortality), Supranuclear Palsy, Progressive (pathology).
- MESH :
- mortality : Lewy Body Disease, Multiple System Atrophy, Parkinson Disease, Parkinsonian Disorders, Supranuclear Palsy, Progressive.
- pathology : Brain, Lewy Body Disease, Multiple System Atrophy, Parkinson Disease, Parkinsonian Disorders, Supranuclear Palsy, Progressive.
- statistics & numerical data : Accidental Falls.
- Adult, Aged, Aged, 80 and over, Disease Progression, Female, Gait, Humans, Male, Middle Aged, Neurologic Examination, Recurrence.
Abstract
Although falls are known to occur in several parkinsonian disorders, such as Parkinson's disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), differences in the evolution of this feature have not been studied systematically in pathologically confirmed cases. Seventy-seven cases with pathologically confirmed parkinsonian disorders (PD: n = 11, MSA: n = 15, DLB: n = 14, CBD: n = 13, PSP: n = 24), collected up to 1994, formed the basis for a multicenter clinicopathologic study organized by the National Institute of Neurological Disorders and Stroke to improve differential diagnosis of parkinsonian disorders. In the present study, we determined the time course, that is, the duration from first symptom to onset (latency) and duration from onset to death, of recurrent falls. Furthermore, we analyzed the diagnostic validity of a predefined latency to onset of recurrent falls within 1 year of symptom onset. Significant group differences for latency, but not duration, of recurrent falls were observed. Latencies to onset of falls were short in PSP patients, intermediate in MSA, DLB, and CBD, and long in PD. Recurrent falls occurring within the first year after disease onset predicted PSP in 68% of the patients. Our study demonstrates for the first time that latency to onset, but not duration, of recurrent falls differentiates PD from other parkinsonian disorders. Whereas early falls are important for the diagnosis of PSP, the addition of other features increases its diagnostic predictive value.
PubMed: 10584668
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Verny</name></author><author><name sortKey="Chaudhuri, K R" sort="Chaudhuri, K R" uniqKey="Chaudhuri K" first="K R" last="Chaudhuri">K R Chaudhuri</name></author><author><name sortKey="Jellinger, K" sort="Jellinger, K" uniqKey="Jellinger K" first="K" last="Jellinger">K. Jellinger</name></author><author><name sortKey="Mckee, A" sort="Mckee, A" uniqKey="Mckee A" first="A" last="Mckee">A. Mckee</name></author><author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I" last="Litvan">I. Litvan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10584668</idno><idno type="pmid">10584668</idno><idno type="wicri:Area/PubMed/Corpus">004097</idno><idno type="wicri:Area/PubMed/Curation">004097</idno><idno type="wicri:Area/PubMed/Checkpoint">004126</idno><idno type="wicri:Area/Ncbi/Merge">000154</idno><idno type="wicri:Area/Ncbi/Curation">000154</idno><idno type="wicri:Area/Ncbi/Checkpoint">000154</idno><idno type="wicri:doubleKey">0885-3185:1999:Wenning G:progression:of:falls</idno><idno type="wicri:Area/Main/Merge">007733</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Progression of falls in postmortem-confirmed parkinsonian disorders.</title><author><name sortKey="Wenning, G K" sort="Wenning, G K" uniqKey="Wenning G" first="G K" last="Wenning">G K Wenning</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University Hospital, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Ebersbach, G" sort="Ebersbach, G" uniqKey="Ebersbach G" first="G" last="Ebersbach">G. Ebersbach</name></author><author><name sortKey="Verny, M" sort="Verny, M" uniqKey="Verny M" first="M" last="Verny">M. Verny</name></author><author><name sortKey="Chaudhuri, K R" sort="Chaudhuri, K R" uniqKey="Chaudhuri K" first="K R" last="Chaudhuri">K R Chaudhuri</name></author><author><name sortKey="Jellinger, K" sort="Jellinger, K" uniqKey="Jellinger K" first="K" last="Jellinger">K. Jellinger</name></author><author><name sortKey="Mckee, A" sort="Mckee, A" uniqKey="Mckee A" first="A" last="Mckee">A. Mckee</name></author><author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I" last="Litvan">I. Litvan</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accidental Falls (statistics & numerical data)</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Brain (pathology)</term><term>Disease Progression</term><term>Female</term><term>Gait</term><term>Humans</term><term>Lewy Body Disease (mortality)</term><term>Lewy Body Disease (pathology)</term><term>Male</term><term>Middle Aged</term><term>Multiple System Atrophy (mortality)</term><term>Multiple System Atrophy (pathology)</term><term>Neurologic Examination</term><term>Parkinson Disease (mortality)</term><term>Parkinson Disease (pathology)</term><term>Parkinsonian Disorders (mortality)</term><term>Parkinsonian Disorders (pathology)</term><term>Recurrence</term><term>Supranuclear Palsy, Progressive (mortality)</term><term>Supranuclear Palsy, Progressive (pathology)</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Lewy Body Disease</term><term>Multiple System Atrophy</term><term>Parkinson Disease</term><term>Parkinsonian Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Lewy Body Disease</term><term>Multiple System Atrophy</term><term>Parkinson Disease</term><term>Parkinsonian Disorders</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Accidental Falls</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Female</term><term>Gait</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Recurrence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although falls are known to occur in several parkinsonian disorders, such as Parkinson's disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), differences in the evolution of this feature have not been studied systematically in pathologically confirmed cases. Seventy-seven cases with pathologically confirmed parkinsonian disorders (PD: n = 11, MSA: n = 15, DLB: n = 14, CBD: n = 13, PSP: n = 24), collected up to 1994, formed the basis for a multicenter clinicopathologic study organized by the National Institute of Neurological Disorders and Stroke to improve differential diagnosis of parkinsonian disorders. In the present study, we determined the time course, that is, the duration from first symptom to onset (latency) and duration from onset to death, of recurrent falls. Furthermore, we analyzed the diagnostic validity of a predefined latency to onset of recurrent falls within 1 year of symptom onset. Significant group differences for latency, but not duration, of recurrent falls were observed. Latencies to onset of falls were short in PSP patients, intermediate in MSA, DLB, and CBD, and long in PD. Recurrent falls occurring within the first year after disease onset predicted PSP in 68% of the patients. Our study demonstrates for the first time that latency to onset, but not duration, of recurrent falls differentiates PD from other parkinsonian disorders. Whereas early falls are important for the diagnosis of PSP, the addition of other features increases its diagnostic predictive value.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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