Worsening of motor performance in patients with Parkinson's disease following transdermal nicotine administration.
Identifieur interne : 007676 ( Main/Merge ); précédent : 007675; suivant : 007677Worsening of motor performance in patients with Parkinson's disease following transdermal nicotine administration.
Auteurs : G. Ebersbach [Autriche] ; M. Stöck ; J. Müller ; G. Wenning ; J. Wissel ; Werner Poewe [Autriche]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1999.
English descriptors
- KwdEn :
- Administration, Cutaneous, Adult, Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Corpus Striatum (drug effects), Corpus Striatum (physiology), Cross-Over Studies, Dopamine (physiology), Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Motor Skills (drug effects), Motor Skills (physiology), Neural Inhibition (drug effects), Neural Inhibition (physiology), Nicotine (administration & dosage), Nicotine (adverse effects), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Substantia Nigra (drug effects), Substantia Nigra (physiopathology).
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Nicotine.
- chemical , adverse effects : Antiparkinson Agents, Nicotine.
- drug effects : Corpus Striatum, Motor Skills, Neural Inhibition, Substantia Nigra.
- drug therapy : Parkinson Disease.
- physiology : Corpus Striatum, Dopamine, Motor Skills, Neural Inhibition.
- physiopathology : Parkinson Disease, Substantia Nigra.
- Administration, Cutaneous, Adult, Aged, Cross-Over Studies, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged.
Abstract
Nicotine has been reported to have positive effects on motor performance in patients with Parkinson's disease. In this study, motor performance was evaluated in 16 patients with idiopathic Parkinson's disease during a practical off-period using the motor part of the Unified Parkinson's Disease Rating Scale after 12 hours' exposure to a transdermal patch containing 35 mg nicotine or placebo. The study was performed using a double-blind crossover design. In contrast to previous reports, nicotine exposure was followed by a worsening of symptoms compared with placebo. A negative response to subthreshold dopaminergic stimulation, resulting from an inhibitory effect of low striatal dopamine concentrations acting on a subset of dopamine receptors, might possibly account for this finding.
PubMed: 10584678
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pubmed:10584678Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Worsening of motor performance in patients with Parkinson's disease following transdermal nicotine administration.</title><author><name sortKey="Ebersbach, G" sort="Ebersbach, G" uniqKey="Ebersbach G" first="G" last="Ebersbach">G. Ebersbach</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Clinic Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University Clinic Innsbruck</wicri:regionArea><wicri:noRegion>University Clinic Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Stock, M" sort="Stock, M" uniqKey="Stock M" first="M" last="Stöck">M. Stöck</name></author><author><name sortKey="Muller, J" sort="Muller, J" uniqKey="Muller J" first="J" last="Müller">J. Müller</name></author><author><name sortKey="Wenning, G" sort="Wenning, G" uniqKey="Wenning G" first="G" last="Wenning">G. Wenning</name></author><author><name sortKey="Wissel, J" sort="Wissel, J" uniqKey="Wissel J" first="J" last="Wissel">J. Wissel</name></author><author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10584678</idno><idno type="pmid">10584678</idno><idno type="wicri:Area/PubMed/Corpus">004087</idno><idno type="wicri:Area/PubMed/Curation">004087</idno><idno type="wicri:Area/PubMed/Checkpoint">004069</idno><idno type="wicri:Area/Ncbi/Merge">000164</idno><idno type="wicri:Area/Ncbi/Curation">000164</idno><idno type="wicri:Area/Ncbi/Checkpoint">000164</idno><idno type="wicri:doubleKey">0885-3185:1999:Ebersbach G:worsening:of:motor</idno><idno type="wicri:Area/Main/Merge">007676</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Worsening of motor performance in patients with Parkinson's disease following transdermal nicotine administration.</title><author><name sortKey="Ebersbach, G" sort="Ebersbach, G" uniqKey="Ebersbach G" first="G" last="Ebersbach">G. Ebersbach</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Clinic Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University Clinic Innsbruck</wicri:regionArea><wicri:noRegion>University Clinic Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Stock, M" sort="Stock, M" uniqKey="Stock M" first="M" last="Stöck">M. Stöck</name></author><author><name sortKey="Muller, J" sort="Muller, J" uniqKey="Muller J" first="J" last="Müller">J. Müller</name></author><author><name sortKey="Wenning, G" sort="Wenning, G" uniqKey="Wenning G" first="G" last="Wenning">G. Wenning</name></author><author><name sortKey="Wissel, J" sort="Wissel, J" uniqKey="Wissel J" first="J" last="Wissel">J. Wissel</name></author><author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W" last="Poewe">Werner Poewe</name><affiliation><country>Autriche</country><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Cutaneous</term><term>Adult</term><term>Aged</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (adverse effects)</term><term>Corpus Striatum (drug effects)</term><term>Corpus Striatum (physiology)</term><term>Cross-Over Studies</term><term>Dopamine (physiology)</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Skills (drug effects)</term><term>Motor Skills (physiology)</term><term>Neural Inhibition (drug effects)</term><term>Neural Inhibition (physiology)</term><term>Nicotine (administration & dosage)</term><term>Nicotine (adverse effects)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Substantia Nigra (drug effects)</term><term>Substantia Nigra (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Nicotine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Nicotine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Corpus Striatum</term><term>Motor Skills</term><term>Neural Inhibition</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Corpus Striatum</term><term>Dopamine</term><term>Motor Skills</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Cutaneous</term><term>Adult</term><term>Aged</term><term>Cross-Over Studies</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nicotine has been reported to have positive effects on motor performance in patients with Parkinson's disease. In this study, motor performance was evaluated in 16 patients with idiopathic Parkinson's disease during a practical off-period using the motor part of the Unified Parkinson's Disease Rating Scale after 12 hours' exposure to a transdermal patch containing 35 mg nicotine or placebo. The study was performed using a double-blind crossover design. In contrast to previous reports, nicotine exposure was followed by a worsening of symptoms compared with placebo. A negative response to subthreshold dopaminergic stimulation, resulting from an inhibitory effect of low striatal dopamine concentrations acting on a subset of dopamine receptors, might possibly account for this finding.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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