Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome.
Identifieur interne : 007158 ( Main/Merge ); précédent : 007157; suivant : 007159Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome.
Auteurs : W G Ondo [États-Unis] ; Y. He ; S. Rajasekaran ; W D LeSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2000.
English descriptors
- KwdEn :
- Adrenergic Agents (toxicity), Animals, Brain Mapping, Diencephalon (drug effects), Diencephalon (pathology), Diencephalon (physiopathology), Disease Models, Animal, Female, Neural Pathways (drug effects), Neural Pathways (pathology), Neural Pathways (physiopathology), Oxidopamine (toxicity), Rats, Rats, Sprague-Dawley, Receptors, Dopamine (drug effects), Receptors, Dopamine (physiology), Restless Legs Syndrome (chemically induced), Restless Legs Syndrome (pathology), Restless Legs Syndrome (physiopathology), Spinal Cord (drug effects), Spinal Cord (pathology), Spinal Cord (physiopathology).
- MESH :
- chemical , drug effects : Receptors, Dopamine.
- chemical , physiology : Receptors, Dopamine.
- chemical , toxicity : Adrenergic Agents, Oxidopamine.
- chemically induced : Restless Legs Syndrome.
- drug effects : Diencephalon, Neural Pathways, Spinal Cord.
- pathology : Diencephalon, Neural Pathways, Restless Legs Syndrome, Spinal Cord.
- physiopathology : Diencephalon, Neural Pathways, Restless Legs Syndrome, Spinal Cord.
- Animals, Brain Mapping, Disease Models, Animal, Female, Rats, Rats, Sprague-Dawley.
Abstract
Pursuant to the clinical suspicion that restless legs syndrome (RLS) may involve dopaminergic diencephalic spinal neurons (A11), we performed stereotaxic bilateral 6-hydroxydopamine (6-OHDA) lesions into the A11 nucleus to observe for any behavioral correlates similar to this clinical condition. Pathologic examination demonstrated a 54% reduction in A11 tyrosine hydroxylase staining cells in rats injected with 6-OHDA versus sham treatment. Multiple blindly rated 90-120-minute video epochs demonstrated an increased average number of standing episodes (14.4+/-11.7 versus 7.3+/-5.5 episodes/epoch) and increased total standing time (38.9+/-20.5 versus 25.3+/-12.2 minutes/epoch) but similar total sleep time in four lesioned rats when compared with two sham rats. Treatment of the lesioned rats with intramuscular pramipexole subsequently resulted in fewer standing episodes (4.4+/-3.3 versus 14.4+/-11.7 episodes/epoch) and less total standing time (20.9+/-12.3 versus 38.9+/-20.5 minutes/epoch) when compared with untreated lesioned rats. Despite a large number of observations, the small number of lesioned animals precluded formal statistical analysis. These behaviors are consistent, although not specific, with what would be expected in an animal model of RLS.
PubMed: 10634257
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 004046
- to stream PubMed, to step Curation: 004046
- to stream PubMed, to step Checkpoint: 004015
- to stream Ncbi, to step Merge: 000205
- to stream Ncbi, to step Curation: 000205
- to stream Ncbi, to step Checkpoint: 000205
Links to Exploration step
pubmed:10634257Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome.</title><author><name sortKey="Ondo, W G" sort="Ondo, W G" uniqKey="Ondo W" first="W G" last="Ondo">W G Ondo</name><affiliation wicri:level="1"><nlm:affiliation>Baylor College of Medicine, Department of Neurology, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Department of Neurology, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="He, Y" sort="He, Y" uniqKey="He Y" first="Y" last="He">Y. He</name></author><author><name sortKey="Rajasekaran, S" sort="Rajasekaran, S" uniqKey="Rajasekaran S" first="S" last="Rajasekaran">S. Rajasekaran</name></author><author><name sortKey="Le, W D" sort="Le, W D" uniqKey="Le W" first="W D" last="Le">W D Le</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10634257</idno><idno type="pmid">10634257</idno><idno type="wicri:Area/PubMed/Corpus">004046</idno><idno type="wicri:Area/PubMed/Curation">004046</idno><idno type="wicri:Area/PubMed/Checkpoint">004015</idno><idno type="wicri:Area/Ncbi/Merge">000205</idno><idno type="wicri:Area/Ncbi/Curation">000205</idno><idno type="wicri:Area/Ncbi/Checkpoint">000205</idno><idno type="wicri:doubleKey">0885-3185:2000:Ondo W:clinical:correlates:of</idno><idno type="wicri:Area/Main/Merge">007158</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome.</title><author><name sortKey="Ondo, W G" sort="Ondo, W G" uniqKey="Ondo W" first="W G" last="Ondo">W G Ondo</name><affiliation wicri:level="1"><nlm:affiliation>Baylor College of Medicine, Department of Neurology, Houston, Texas 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baylor College of Medicine, Department of Neurology, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="He, Y" sort="He, Y" uniqKey="He Y" first="Y" last="He">Y. He</name></author><author><name sortKey="Rajasekaran, S" sort="Rajasekaran, S" uniqKey="Rajasekaran S" first="S" last="Rajasekaran">S. Rajasekaran</name></author><author><name sortKey="Le, W D" sort="Le, W D" uniqKey="Le W" first="W D" last="Le">W D Le</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic Agents (toxicity)</term><term>Animals</term><term>Brain Mapping</term><term>Diencephalon (drug effects)</term><term>Diencephalon (pathology)</term><term>Diencephalon (physiopathology)</term><term>Disease Models, Animal</term><term>Female</term><term>Neural Pathways (drug effects)</term><term>Neural Pathways (pathology)</term><term>Neural Pathways (physiopathology)</term><term>Oxidopamine (toxicity)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Receptors, Dopamine (drug effects)</term><term>Receptors, Dopamine (physiology)</term><term>Restless Legs Syndrome (chemically induced)</term><term>Restless Legs Syndrome (pathology)</term><term>Restless Legs Syndrome (physiopathology)</term><term>Spinal Cord (drug effects)</term><term>Spinal Cord (pathology)</term><term>Spinal Cord (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Adrenergic Agents</term><term>Oxidopamine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Diencephalon</term><term>Neural Pathways</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Diencephalon</term><term>Neural Pathways</term><term>Restless Legs Syndrome</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Diencephalon</term><term>Neural Pathways</term><term>Restless Legs Syndrome</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brain Mapping</term><term>Disease Models, Animal</term><term>Female</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pursuant to the clinical suspicion that restless legs syndrome (RLS) may involve dopaminergic diencephalic spinal neurons (A11), we performed stereotaxic bilateral 6-hydroxydopamine (6-OHDA) lesions into the A11 nucleus to observe for any behavioral correlates similar to this clinical condition. Pathologic examination demonstrated a 54% reduction in A11 tyrosine hydroxylase staining cells in rats injected with 6-OHDA versus sham treatment. Multiple blindly rated 90-120-minute video epochs demonstrated an increased average number of standing episodes (14.4+/-11.7 versus 7.3+/-5.5 episodes/epoch) and increased total standing time (38.9+/-20.5 versus 25.3+/-12.2 minutes/epoch) but similar total sleep time in four lesioned rats when compared with two sham rats. Treatment of the lesioned rats with intramuscular pramipexole subsequently resulted in fewer standing episodes (4.4+/-3.3 versus 14.4+/-11.7 episodes/epoch) and less total standing time (20.9+/-12.3 versus 38.9+/-20.5 minutes/epoch) when compared with untreated lesioned rats. Despite a large number of observations, the small number of lesioned animals precluded formal statistical analysis. These behaviors are consistent, although not specific, with what would be expected in an animal model of RLS.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007158 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 007158 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Merge
|type= RBID
|clé= pubmed:10634257
|texte= Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:10634257" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |