Quantitative digitography (QDG): a sensitive measure of digital motor control in idiopathic Parkinson's disease.
Identifieur interne : 007033 ( Main/Merge ); précédent : 007032; suivant : 007034Quantitative digitography (QDG): a sensitive measure of digital motor control in idiopathic Parkinson's disease.
Auteurs : H M Bronte-Stewart [États-Unis] ; L. Ding ; C. Alexander ; Y. Zhou ; G P MooreSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2000.
English descriptors
- KwdEn :
- Adult, Aged, Ambulatory Care, Antiparkinson Agents (administration & dosage), Diagnosis, Computer-Assisted (instrumentation), Female, Globus Pallidus (physiopathology), Globus Pallidus (surgery), Humans, Male, Middle Aged, Motor Skills (drug effects), Motor Skills (physiology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Reaction Time (drug effects), Reaction Time (physiology), Sensitivity and Specificity, Software, User-Computer Interface.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents.
- diagnosis : Parkinson Disease.
- drug effects : Motor Skills, Reaction Time.
- instrumentation : Diagnosis, Computer-Assisted.
- physiology : Motor Skills, Reaction Time.
- physiopathology : Globus Pallidus, Parkinson Disease.
- surgery : Globus Pallidus.
- therapy : Parkinson Disease.
- Adult, Aged, Ambulatory Care, Female, Humans, Male, Middle Aged, Sensitivity and Specificity, Software, User-Computer Interface.
Abstract
This study introduces a new method for studying, quantitatively, the dynamics of finger movement using data obtained from sequences of key strikes on a computer-interfaced piano keyboard. We have called this quantitative digitography (QDG). This initial article introduces the method in a group of patients with Parkinson's disease and in a group of healthy subjects using simple, repetitive, alternating finger-tapping for 60 seconds. Patients with idiopathic Parkinson's disease (IPD) were studied "ON" and "OFF" dopaminergic medication before and after pallidotomy. Customized software allowed the independent analysis of key strike velocity, duration of key strike, and frequency of tapping along with a quantitative measure of the regularity of performance. Quantitative measures of the improvement in performance after medication are presented for each parameter of movement. The technique also reveals correlates of some clinical phenomena of the temporal disturbances of repetitive motion in IPD, such as fatigue, tremor, freezing, and festination. We demonstrate that the performance of 60 seconds of alternating finger tapping on a computerized keyboard yields objective measures of motor performance that are significantly different in patients with IPD "OFF" when compared with "ON" medication and when compared with healthy subjects. This is the first time that such a method has been used in the measurement of specific kinematics of digital motion in Parkinson's disease. The equipment is inexpensive and portable and the data are rapidly and easily collected, making it suitable for the outpatient setting.
PubMed: 10634240
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pubmed:10634240Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quantitative digitography (QDG): a sensitive measure of digital motor control in idiopathic Parkinson's disease.</title><author><name sortKey="Bronte Stewart, H M" sort="Bronte Stewart, H M" uniqKey="Bronte Stewart H" first="H M" last="Bronte-Stewart">H M Bronte-Stewart</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Neurological Sciences, Stanford University Medical Center, California 94305-5235, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Neurological Sciences, Stanford University Medical Center, California 94305-5235</wicri:regionArea><wicri:noRegion>California 94305-5235</wicri:noRegion></affiliation></author><author><name sortKey="Ding, L" sort="Ding, L" uniqKey="Ding L" first="L" last="Ding">L. Ding</name></author><author><name sortKey="Alexander, C" sort="Alexander, C" uniqKey="Alexander C" first="C" last="Alexander">C. Alexander</name></author><author><name sortKey="Zhou, Y" sort="Zhou, Y" uniqKey="Zhou Y" first="Y" last="Zhou">Y. Zhou</name></author><author><name sortKey="Moore, G P" sort="Moore, G P" uniqKey="Moore G" first="G P" last="Moore">G P Moore</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10634240</idno><idno type="pmid">10634240</idno><idno type="wicri:Area/PubMed/Corpus">004063</idno><idno type="wicri:Area/PubMed/Curation">004063</idno><idno type="wicri:Area/PubMed/Checkpoint">003E90</idno><idno type="wicri:Area/Ncbi/Merge">000188</idno><idno type="wicri:Area/Ncbi/Curation">000188</idno><idno type="wicri:Area/Ncbi/Checkpoint">000188</idno><idno type="wicri:doubleKey">0885-3185:2000:Bronte Stewart H:quantitative:digitography:qdg</idno><idno type="wicri:Area/Main/Merge">007033</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Quantitative digitography (QDG): a sensitive measure of digital motor control in idiopathic Parkinson's disease.</title><author><name sortKey="Bronte Stewart, H M" sort="Bronte Stewart, H M" uniqKey="Bronte Stewart H" first="H M" last="Bronte-Stewart">H M Bronte-Stewart</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Neurological Sciences, Stanford University Medical Center, California 94305-5235, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Neurological Sciences, Stanford University Medical Center, California 94305-5235</wicri:regionArea><wicri:noRegion>California 94305-5235</wicri:noRegion></affiliation></author><author><name sortKey="Ding, L" sort="Ding, L" uniqKey="Ding L" first="L" last="Ding">L. Ding</name></author><author><name sortKey="Alexander, C" sort="Alexander, C" uniqKey="Alexander C" first="C" last="Alexander">C. Alexander</name></author><author><name sortKey="Zhou, Y" sort="Zhou, Y" uniqKey="Zhou Y" first="Y" last="Zhou">Y. Zhou</name></author><author><name sortKey="Moore, G P" sort="Moore, G P" uniqKey="Moore G" first="G P" last="Moore">G P Moore</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Ambulatory Care</term><term>Antiparkinson Agents (administration & dosage)</term><term>Diagnosis, Computer-Assisted (instrumentation)</term><term>Female</term><term>Globus Pallidus (physiopathology)</term><term>Globus Pallidus (surgery)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Skills (drug effects)</term><term>Motor Skills (physiology)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Reaction Time (drug effects)</term><term>Reaction Time (physiology)</term><term>Sensitivity and Specificity</term><term>Software</term><term>User-Computer Interface</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Skills</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Diagnosis, Computer-Assisted</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Skills</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Globus Pallidus</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Ambulatory Care</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Sensitivity and Specificity</term><term>Software</term><term>User-Computer Interface</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study introduces a new method for studying, quantitatively, the dynamics of finger movement using data obtained from sequences of key strikes on a computer-interfaced piano keyboard. We have called this quantitative digitography (QDG). This initial article introduces the method in a group of patients with Parkinson's disease and in a group of healthy subjects using simple, repetitive, alternating finger-tapping for 60 seconds. Patients with idiopathic Parkinson's disease (IPD) were studied "ON" and "OFF" dopaminergic medication before and after pallidotomy. Customized software allowed the independent analysis of key strike velocity, duration of key strike, and frequency of tapping along with a quantitative measure of the regularity of performance. Quantitative measures of the improvement in performance after medication are presented for each parameter of movement. The technique also reveals correlates of some clinical phenomena of the temporal disturbances of repetitive motion in IPD, such as fatigue, tremor, freezing, and festination. We demonstrate that the performance of 60 seconds of alternating finger tapping on a computerized keyboard yields objective measures of motor performance that are significantly different in patients with IPD "OFF" when compared with "ON" medication and when compared with healthy subjects. This is the first time that such a method has been used in the measurement of specific kinematics of digital motion in Parkinson's disease. The equipment is inexpensive and portable and the data are rapidly and easily collected, making it suitable for the outpatient setting.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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