Resting regional cerebral glucose metabolism in advanced Parkinson's disease studied in the Off and On conditions with [18F]FDG-PET
Identifieur interne : 006E14 ( Main/Merge ); précédent : 006E13; suivant : 006E15Resting regional cerebral glucose metabolism in advanced Parkinson's disease studied in the Off and On conditions with [18F]FDG-PET
Auteurs : Georg Berding [Allemagne] ; Per Odin [Allemagne] ; David J. Brooks [Royaume-Uni] ; Guido Nikkhah [Allemagne] ; Cordula Matthies [Allemagne] ; Thomas Peschel [Allemagne] ; Mona Shing [Allemagne] ; Hans Kolbe [Allemagne] ; Jörg Van Den Hoff [Allemagne] ; Harald Fricke [Allemagne] ; Reinhard Dengler [Allemagne] ; Madjid Samii [Allemagne] ; Wolfram H. Knapp [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2001.
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Abstract
Studies of resting regional cerebral glucose consumption (rCMRGlc) in nondemented patients with Parkinson disease (PD) have produced conflicting results, reporting both reduced and normal metabolism in advanced disease and reduced or normal metabolism after dopaminergic therapy. To investigate these issues, [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) was performed in 1 nondemented PD patients with advanced disease and 10 age-matched controls. PD patients were studied after withdrawal of all dopaminergic medication to produce a practically defined off condition, and a second time I hour after levodopa, resulting in a clinical on state. Dynamic PET scans and simultaneous arterialised venous blood samples of [18F] acticvity were obtained. A graphical approach was used to generate parametric images of rCMRGlc and statistical parametric mapping to localise significant metabolic changes in PD. Compared with controls, global rCMRGlc was reduced in the on but not in the off condition in PD. In both states, significant regional reductions of glucose uptake were found in the parietal, frontal, temporal cortex, and caudate nucleus, Reductions correlated with the severity of disability in frontal and temporal cortex. Direct comparison between on and off conditions revealed relatively greater reductions of uptake in the ventral/orbital frontal cortex and the thalamus during on. Results suggest that cortical and caudate hypometabolism are common in advanced PD and that caution is mandatory if [18F]FDG PET is being used to differentiate advanced PD from dementia and progressive supranuclear palsy where similar reductions are seen. Furthermore, in PD, administration of levodopa is associated with further hypometabolism in orbitofrontal cortex; an area known to be relevant for reversal learning where performance is typically impaired after dopaminergic treatment.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Resting regional cerebral glucose metabolism in advanced Parkinson's disease studied in the Off and On conditions with [<sup>18</sup>F]FDG-PET</title><author><name sortKey="Berding, Georg" sort="Berding, Georg" uniqKey="Berding G" first="Georg" last="Berding">Georg Berding</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Odin, Per" sort="Odin, Per" uniqKey="Odin P" first="Per" last="Odin">Per Odin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, University of Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Nikkhah, Guido" sort="Nikkhah, Guido" uniqKey="Nikkhah G" first="Guido" last="Nikkhah">Guido Nikkhah</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Nordstadt Hospital and University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Matthies, Cordula" sort="Matthies, Cordula" uniqKey="Matthies C" first="Cordula" last="Matthies">Cordula Matthies</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Nordstadt Hospital and University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Peschel, Thomas" sort="Peschel, Thomas" uniqKey="Peschel T" first="Thomas" last="Peschel">Thomas Peschel</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Shing, Mona" sort="Shing, Mona" uniqKey="Shing M" first="Mona" last="Shing">Mona Shing</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, University of Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Kolbe, Hans" sort="Kolbe, Hans" uniqKey="Kolbe H" first="Hans" last="Kolbe">Hans Kolbe</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Van Den Hoff, Jorg" sort="Van Den Hoff, Jorg" uniqKey="Van Den Hoff J" first="Jörg" last="Van Den Hoff">Jörg Van Den Hoff</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Fricke, Harald" sort="Fricke, Harald" uniqKey="Fricke H" first="Harald" last="Fricke">Harald Fricke</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Dengler, Reinhard" sort="Dengler, Reinhard" uniqKey="Dengler R" first="Reinhard" last="Dengler">Reinhard Dengler</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Samii, Madjid" sort="Samii, Madjid" uniqKey="Samii M" first="Madjid" last="Samii">Madjid Samii</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Nordstadt Hospital and University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Knapp, Wolfram H" sort="Knapp, Wolfram H" uniqKey="Knapp W" first="Wolfram H." last="Knapp">Wolfram H. Knapp</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">02-0177036</idno><date when="2001">2001</date><idno type="stanalyst">PASCAL 02-0177036 INIST</idno><idno type="RBID">Pascal:02-0177036</idno><idno type="wicri:Area/PascalFrancis/Corpus">002886</idno><idno type="wicri:Area/PascalFrancis/Curation">000435</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002915</idno><idno type="wicri:doubleKey">0885-3185:2001:Berding G:resting:regional:cerebral</idno><idno type="wicri:Area/Main/Merge">006E14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Resting regional cerebral glucose metabolism in advanced Parkinson's disease studied in the Off and On conditions with [<sup>18</sup>F]FDG-PET</title><author><name sortKey="Berding, Georg" sort="Berding, Georg" uniqKey="Berding G" first="Georg" last="Berding">Georg Berding</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Odin, Per" sort="Odin, Per" uniqKey="Odin P" first="Per" last="Odin">Per Odin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, University of Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Medical Research Council Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Nikkhah, Guido" sort="Nikkhah, Guido" uniqKey="Nikkhah G" first="Guido" last="Nikkhah">Guido Nikkhah</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Nordstadt Hospital and University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Matthies, Cordula" sort="Matthies, Cordula" uniqKey="Matthies C" first="Cordula" last="Matthies">Cordula Matthies</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Nordstadt Hospital and University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Peschel, Thomas" sort="Peschel, Thomas" uniqKey="Peschel T" first="Thomas" last="Peschel">Thomas Peschel</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Shing, Mona" sort="Shing, Mona" uniqKey="Shing M" first="Mona" last="Shing">Mona Shing</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, University of Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Kolbe, Hans" sort="Kolbe, Hans" uniqKey="Kolbe H" first="Hans" last="Kolbe">Hans Kolbe</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Van Den Hoff, Jorg" sort="Van Den Hoff, Jorg" uniqKey="Van Den Hoff J" first="Jörg" last="Van Den Hoff">Jörg Van Den Hoff</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Fricke, Harald" sort="Fricke, Harald" uniqKey="Fricke H" first="Harald" last="Fricke">Harald Fricke</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Dengler, Reinhard" sort="Dengler, Reinhard" uniqKey="Dengler R" first="Reinhard" last="Dengler">Reinhard Dengler</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Samii, Madjid" sort="Samii, Madjid" uniqKey="Samii M" first="Madjid" last="Samii">Madjid Samii</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurosurgery, Nordstadt Hospital and University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Knapp, Wolfram H" sort="Knapp, Wolfram H" uniqKey="Knapp W" first="Wolfram H." last="Knapp">Wolfram H. Knapp</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Nuclear Medicine, University Medical School</s1><s2>Hannover</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain (vertebrata)</term><term>Emission tomography</term><term>Exploration</term><term>Glucose</term><term>Human</term><term>Metabolism</term><term>Parkinson disease</term><term>Positron</term><term>Rest</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Tomoscintigraphie</term><term>Positon</term><term>Métabolisme</term><term>Glucose</term><term>Encéphale</term><term>Repos</term><term>Exploration</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Glucose</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Studies of resting regional cerebral glucose consumption (rCMRGlc) in nondemented patients with Parkinson disease (PD) have produced conflicting results, reporting both reduced and normal metabolism in advanced disease and reduced or normal metabolism after dopaminergic therapy. To investigate these issues, [<sup>18</sup>F]fluorodeoxyglucose (FDG) positron emission tomography (PET) was performed in 1 nondemented PD patients with advanced disease and 10 age-matched controls. PD patients were studied after withdrawal of all dopaminergic medication to produce a practically defined off condition, and a second time I hour after levodopa, resulting in a clinical on state. Dynamic PET scans and simultaneous arterialised venous blood samples of [<sup>18</sup>F] acticvity were obtained. A graphical approach was used to generate parametric images of rCMRGlc and statistical parametric mapping to localise significant metabolic changes in PD. Compared with controls, global rCMRGlc was reduced in the on but not in the off condition in PD. In both states, significant regional reductions of glucose uptake were found in the parietal, frontal, temporal cortex, and caudate nucleus, Reductions correlated with the severity of disability in frontal and temporal cortex. Direct comparison between on and off conditions revealed relatively greater reductions of uptake in the ventral/orbital frontal cortex and the thalamus during on. Results suggest that cortical and caudate hypometabolism are common in advanced PD and that caution is mandatory if [<sup>18</sup>F]FDG PET is being used to differentiate advanced PD from dementia and progressive supranuclear palsy where similar reductions are seen. Furthermore, in PD, administration of levodopa is associated with further hypometabolism in orbitofrontal cortex; an area known to be relevant for reversal learning where performance is typically impaired after dopaminergic treatment.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Basse-Saxe</li><li>District de Giessen</li><li>Grand Londres</li><li>Hesse (Land)</li></region><settlement><li>Hanovre</li><li>Londres</li><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Berding, Georg" sort="Berding, Georg" uniqKey="Berding G" first="Georg" last="Berding">Georg Berding</name></region><name sortKey="Dengler, Reinhard" sort="Dengler, Reinhard" uniqKey="Dengler R" first="Reinhard" last="Dengler">Reinhard Dengler</name><name sortKey="Fricke, Harald" sort="Fricke, Harald" uniqKey="Fricke H" first="Harald" last="Fricke">Harald Fricke</name><name sortKey="Knapp, Wolfram H" sort="Knapp, Wolfram H" uniqKey="Knapp W" first="Wolfram H." last="Knapp">Wolfram H. Knapp</name><name sortKey="Kolbe, Hans" sort="Kolbe, Hans" uniqKey="Kolbe H" first="Hans" last="Kolbe">Hans Kolbe</name><name sortKey="Matthies, Cordula" sort="Matthies, Cordula" uniqKey="Matthies C" first="Cordula" last="Matthies">Cordula Matthies</name><name sortKey="Nikkhah, Guido" sort="Nikkhah, Guido" uniqKey="Nikkhah G" first="Guido" last="Nikkhah">Guido Nikkhah</name><name sortKey="Odin, Per" sort="Odin, Per" uniqKey="Odin P" first="Per" last="Odin">Per Odin</name><name sortKey="Peschel, Thomas" sort="Peschel, Thomas" uniqKey="Peschel T" first="Thomas" last="Peschel">Thomas Peschel</name><name sortKey="Samii, Madjid" sort="Samii, Madjid" uniqKey="Samii M" first="Madjid" last="Samii">Madjid Samii</name><name sortKey="Shing, Mona" sort="Shing, Mona" uniqKey="Shing M" first="Mona" last="Shing">Mona Shing</name><name sortKey="Shing, Mona" sort="Shing, Mona" uniqKey="Shing M" first="Mona" last="Shing">Mona Shing</name><name sortKey="Van Den Hoff, Jorg" sort="Van Den Hoff, Jorg" uniqKey="Van Den Hoff J" first="Jörg" last="Van Den Hoff">Jörg Van Den Hoff</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. 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|type= RBID
|clé= Pascal:02-0177036
|texte= Resting regional cerebral glucose metabolism in advanced Parkinson's disease studied in the Off and On conditions with [18F]FDG-PET
}}
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