The auditory startle reaction in Parkinsonian disorders
Identifieur interne : 006D91 ( Main/Merge ); précédent : 006D90; suivant : 006D92The auditory startle reaction in Parkinsonian disorders
Auteurs : Markus Kofler [Autriche] ; Jörg Müller [Espagne] ; Gregor K. Wenning [Espagne] ; Laura Reggiani [Espagne] ; Pia Hollosi [Espagne] ; Sylvia Bösch [Espagne] ; Gerhard Ransmayr [Espagne] ; Josep Valls-Sole [Autriche] ; Werner Poewe [Espagne]Source :
- Movement disorders [ 0885-3185 ] ; 2001.
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Abstract
The auditory startle reaction to an unexpected loud stimulus is regarded as a brainstem reflex originating in the nucleus reticularis pontis caudalis and being distributed up the brainstem and down the spinal cord along slowly conducting pathways. Auditory startle responses (ASR) have been reported absent or reduced in progressive supranuclear palsy (PSP), and delayed in Parkinson's disease (PD), but normal in multiple-system atrophy (MSA). For the first time we studied ASR in patients fulfilling the clinical criteria of dementia with Lewy bodies (DLB) (n = 8), a neurodegenerative disorder characterized by cortical and subcortical depositions of Lewy bodies resulting in parkinsonism and progressive cognitive decline. For comparison, we also investigated patients with PD (n = 10), MSA (n = 7), PSP (n = 10), and age-matched healthy controls (n = 10). ASR were elicited by binaural high-intensity auditory stimuli. Surface electromyographic activity was simultaneously recorded from facial, upper, and lower extremity muscles. For each muscle, we assessed response probability and measured latency, amplitude, duration, and habituation rate. Patients with DLB had fewer and abnormally delayed ASR of low amplitude and short duration in extremity muscles compared to healthy controls. Furthermore, we confirm and extend previous findings of abnormal ASR in PSP and PD, and also demonstrate exaggerated ASR in extremity muscles of MSA patients. The different patterns of ASR abnormalities may reflect distinct types of brainstem dysfunction in DLB, PD, MSA, and PSP.
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Pia" sort="Hollosi, Pia" uniqKey="Hollosi P" first="Pia" last="Hollosi">Pia Hollosi</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Servei de Neurologia, Hospital Clinic</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bosch, Sylvia" sort="Bosch, Sylvia" uniqKey="Bosch S" first="Sylvia" last="Bösch">Sylvia Bösch</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Servei de Neurologia, Hospital Clinic</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ransmayr, Gerhard" sort="Ransmayr, Gerhard" uniqKey="Ransmayr G" first="Gerhard" last="Ransmayr">Gerhard Ransmayr</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Servei de Neurologia, Hospital Clinic</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Valls Sole, Josep" sort="Valls Sole, Josep" uniqKey="Valls Sole J" first="Josep" last="Valls-Sole">Josep Valls-Sole</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Innsbruck</s1><s3>AUT</s3><sZ>8 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Neurology, University Hospital Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Servei de Neurologia, Hospital Clinic</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Auditory reflex</term><term>Comparative study</term><term>Dementia</term><term>Electrodiagnosis</term><term>Exploration</term><term>Human</term><term>Lewy body</term><term>Multiple system atrophy</term><term>Parkinson disease</term><term>Progressive</term><term>Supranuclear ophthalmoplegia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Ophtalmoplégie supranucléaire</term><term>Progressif</term><term>Démence</term><term>Corps Lewy</term><term>Atrophie multisystématisée</term><term>Réflexe auditif</term><term>Etude comparative</term><term>Exploration</term><term>Homme</term><term>Electrodiagnostic</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The auditory startle reaction to an unexpected loud stimulus is regarded as a brainstem reflex originating in the nucleus reticularis pontis caudalis and being distributed up the brainstem and down the spinal cord along slowly conducting pathways. Auditory startle responses (ASR) have been reported absent or reduced in progressive supranuclear palsy (PSP), and delayed in Parkinson's disease (PD), but normal in multiple-system atrophy (MSA). For the first time we studied ASR in patients fulfilling the clinical criteria of dementia with Lewy bodies (DLB) (n = 8), a neurodegenerative disorder characterized by cortical and subcortical depositions of Lewy bodies resulting in parkinsonism and progressive cognitive decline. For comparison, we also investigated patients with PD (n = 10), MSA (n = 7), PSP (n = 10), and age-matched healthy controls (n = 10). ASR were elicited by binaural high-intensity auditory stimuli. Surface electromyographic activity was simultaneously recorded from facial, upper, and lower extremity muscles. For each muscle, we assessed response probability and measured latency, amplitude, duration, and habituation rate. Patients with DLB had fewer and abnormally delayed ASR of low amplitude and short duration in extremity muscles compared to healthy controls. Furthermore, we confirm and extend previous findings of abnormal ASR in PSP and PD, and also demonstrate exaggerated ASR in extremity muscles of MSA patients. The different patterns of ASR abnormalities may reflect distinct types of brainstem dysfunction in DLB, PD, MSA, and PSP.</div></front></TEI><affiliations><list><country><li>Autriche</li><li>Espagne</li></country><region><li>Catalogne</li><li>Tyrol (Land)</li></region><settlement><li>Barcelone</li><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Kofler, Markus" sort="Kofler, Markus" uniqKey="Kofler M" first="Markus" last="Kofler">Markus Kofler</name></noRegion><name sortKey="Valls Sole, Josep" sort="Valls Sole, Josep" uniqKey="Valls Sole J" first="Josep" last="Valls-Sole">Josep Valls-Sole</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Muller, Jorg" sort="Muller, Jorg" uniqKey="Muller J" first="Jörg" last="Müller">Jörg Müller</name></region><name sortKey="Bosch, Sylvia" sort="Bosch, Sylvia" uniqKey="Bosch S" first="Sylvia" last="Bösch">Sylvia Bösch</name><name sortKey="Hollosi, Pia" sort="Hollosi, Pia" uniqKey="Hollosi P" first="Pia" last="Hollosi">Pia Hollosi</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Ransmayr, Gerhard" sort="Ransmayr, Gerhard" uniqKey="Ransmayr G" first="Gerhard" last="Ransmayr">Gerhard Ransmayr</name><name sortKey="Reggiani, Laura" sort="Reggiani, Laura" uniqKey="Reggiani L" first="Laura" last="Reggiani">Laura Reggiani</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. 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