MovDisordV3, Main, Merge, bibRecord, 006D71

[123I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's Disease and multiple system atrophy

Identifieur interne : 006D71 ( Main/Merge ); précédent : 006D70; suivant : 006D72

[123I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's Disease and multiple system atrophy

Auteurs : Andrea Varrone [États-Unis] ; Kenneth L. Marek [États-Unis] ; Danna Jennings [États-Unis] ; Robert B. Innis [États-Unis] ; John P. Seibyl [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2001.

RBID : Pascal:02-0176678

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Atrophie multisystématisée, Tomoscintigraphie, Photon, Corps strié, Transport biologique, Dopamine, Etude comparative, Exploration, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Biological transport, Comparative study, Corpus striatum, Dopamine, Emission tomography, Exploration, Human, Multiple system atrophy, Parkinson disease, Photon.

Abstract

In vivo imaging of the dopamine transporter (DAT) with single photon emission computed tomography (SPECT) is a quantitative biomarker for Parkinson's disease (PD) onset and severity. This study has examined and compared the loss of striatal DAT in PD and multiple system atrophy (MSA) using [¹²³I]β-CIT SPECT imaging. One hundred and eighty-three patients (157 PD and 26 MSA) were studied. Clinical rating scales (Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale [UPDRS] scores) demonstrated that the MSA patients were more severely impaired than the PD patients. The striatal [¹²³I]β-CIT SPECT uptake was markedly reduced in both the PD and MSA groups. In addition, MSA patients showed more symmetric DAT loss compared with the PD patients, consistent with the more symmetric clinical motor dysfunction observed in MSA. While the loss of DAT was significantly reduced in all regions in both MSA and PD, comparison of the relative loss of the DAT did not significantly improve diagnostic accuracy in distinguishing between PD and MSA.

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Pascal:02-0176678

Le document en format XML

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I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's Disease and multiple system atrophy</title>
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I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's Disease and multiple system atrophy</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological transport</term>
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<term>Emission tomography</term>
<term>Exploration</term>
<term>Human</term>
<term>Multiple system atrophy</term>
<term>Parkinson disease</term>
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<term>Corps strié</term>
<term>Transport biologique</term>
<term>Dopamine</term>
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<front><div type="abstract" xml:lang="en">In vivo imaging of the dopamine transporter (DAT) with single photon emission computed tomography (SPECT) is a quantitative biomarker for Parkinson's disease (PD) onset and severity. This study has examined and compared the loss of striatal DAT in PD and multiple system atrophy (MSA) using [<sup>123</sup>
I]β-CIT SPECT imaging. One hundred and eighty-three patients (157 PD and 26 MSA) were studied. Clinical rating scales (Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale [UPDRS] scores) demonstrated that the MSA patients were more severely impaired than the PD patients. The striatal [<sup>123</sup>
I]β-CIT SPECT uptake was markedly reduced in both the PD and MSA groups. In addition, MSA patients showed more symmetric DAT loss compared with the PD patients, consistent with the more symmetric clinical motor dysfunction observed in MSA. While the loss of DAT was significantly reduced in all regions in both MSA and PD, comparison of the relative loss of the DAT did not significantly improve diagnostic accuracy in distinguishing between PD and MSA.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
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<tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Varrone, Andrea" sort="Varrone, Andrea" uniqKey="Varrone A" first="Andrea" last="Varrone">Andrea Varrone</name>
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<name sortKey="Innis, Robert B" sort="Innis, Robert B" uniqKey="Innis R" first="Robert B." last="Innis">Robert B. Innis</name>
<name sortKey="Innis, Robert B" sort="Innis, Robert B" uniqKey="Innis R" first="Robert B." last="Innis">Robert B. Innis</name>
<name sortKey="Innis, Robert B" sort="Innis, Robert B" uniqKey="Innis R" first="Robert B." last="Innis">Robert B. Innis</name>
<name sortKey="Jennings, Danna" sort="Jennings, Danna" uniqKey="Jennings D" first="Danna" last="Jennings">Danna Jennings</name>
<name sortKey="Marek, Kenneth L" sort="Marek, Kenneth L" uniqKey="Marek K" first="Kenneth L." last="Marek">Kenneth L. Marek</name>
<name sortKey="Seibyl, John P" sort="Seibyl, John P" uniqKey="Seibyl J" first="John P." last="Seibyl">John P. Seibyl</name>
<name sortKey="Seibyl, John P" sort="Seibyl, John P" uniqKey="Seibyl J" first="John P." last="Seibyl">John P. Seibyl</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

[123I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's Disease and multiple system atrophy

[123I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's Disease and multiple system atrophy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri