[123I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's Disease and multiple system atrophy
Identifieur interne : 006D71 ( Main/Merge ); précédent : 006D70; suivant : 006D72[123I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's Disease and multiple system atrophy
Auteurs : Andrea Varrone [États-Unis] ; Kenneth L. Marek [États-Unis] ; Danna Jennings [États-Unis] ; Robert B. Innis [États-Unis] ; John P. Seibyl [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2001.
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- Pascal (Inist)
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- topic : Homme.
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Abstract
In vivo imaging of the dopamine transporter (DAT) with single photon emission computed tomography (SPECT) is a quantitative biomarker for Parkinson's disease (PD) onset and severity. This study has examined and compared the loss of striatal DAT in PD and multiple system atrophy (MSA) using [123I]β-CIT SPECT imaging. One hundred and eighty-three patients (157 PD and 26 MSA) were studied. Clinical rating scales (Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale [UPDRS] scores) demonstrated that the MSA patients were more severely impaired than the PD patients. The striatal [123I]β-CIT SPECT uptake was markedly reduced in both the PD and MSA groups. In addition, MSA patients showed more symmetric DAT loss compared with the PD patients, consistent with the more symmetric clinical motor dysfunction observed in MSA. While the loss of DAT was significantly reduced in all regions in both MSA and PD, comparison of the relative loss of the DAT did not significantly improve diagnostic accuracy in distinguishing between PD and MSA.
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I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's Disease and multiple system atrophy</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">[<sup>123</sup>
I]β-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's Disease and multiple system atrophy</title>
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<author><name sortKey="Innis, Robert B" sort="Innis, Robert B" uniqKey="Innis R" first="Robert B." last="Innis">Robert B. Innis</name>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological transport</term>
<term>Comparative study</term>
<term>Corpus striatum</term>
<term>Dopamine</term>
<term>Emission tomography</term>
<term>Exploration</term>
<term>Human</term>
<term>Multiple system atrophy</term>
<term>Parkinson disease</term>
<term>Photon</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Atrophie multisystématisée</term>
<term>Tomoscintigraphie</term>
<term>Photon</term>
<term>Corps strié</term>
<term>Transport biologique</term>
<term>Dopamine</term>
<term>Etude comparative</term>
<term>Exploration</term>
<term>Homme</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">In vivo imaging of the dopamine transporter (DAT) with single photon emission computed tomography (SPECT) is a quantitative biomarker for Parkinson's disease (PD) onset and severity. This study has examined and compared the loss of striatal DAT in PD and multiple system atrophy (MSA) using [<sup>123</sup>
I]β-CIT SPECT imaging. One hundred and eighty-three patients (157 PD and 26 MSA) were studied. Clinical rating scales (Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale [UPDRS] scores) demonstrated that the MSA patients were more severely impaired than the PD patients. The striatal [<sup>123</sup>
I]β-CIT SPECT uptake was markedly reduced in both the PD and MSA groups. In addition, MSA patients showed more symmetric DAT loss compared with the PD patients, consistent with the more symmetric clinical motor dysfunction observed in MSA. While the loss of DAT was significantly reduced in all regions in both MSA and PD, comparison of the relative loss of the DAT did not significantly improve diagnostic accuracy in distinguishing between PD and MSA.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
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<region><li>Connecticut</li>
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<tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Varrone, Andrea" sort="Varrone, Andrea" uniqKey="Varrone A" first="Andrea" last="Varrone">Andrea Varrone</name>
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<name sortKey="Innis, Robert B" sort="Innis, Robert B" uniqKey="Innis R" first="Robert B." last="Innis">Robert B. Innis</name>
<name sortKey="Innis, Robert B" sort="Innis, Robert B" uniqKey="Innis R" first="Robert B." last="Innis">Robert B. Innis</name>
<name sortKey="Innis, Robert B" sort="Innis, Robert B" uniqKey="Innis R" first="Robert B." last="Innis">Robert B. Innis</name>
<name sortKey="Jennings, Danna" sort="Jennings, Danna" uniqKey="Jennings D" first="Danna" last="Jennings">Danna Jennings</name>
<name sortKey="Marek, Kenneth L" sort="Marek, Kenneth L" uniqKey="Marek K" first="Kenneth L." last="Marek">Kenneth L. Marek</name>
<name sortKey="Seibyl, John P" sort="Seibyl, John P" uniqKey="Seibyl J" first="John P." last="Seibyl">John P. Seibyl</name>
<name sortKey="Seibyl, John P" sort="Seibyl, John P" uniqKey="Seibyl J" first="John P." last="Seibyl">John P. Seibyl</name>
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