Selective loss of pyramidal neurons in the pre-supplementary motor cortex in Parkinson's disease
Identifieur interne : 006654 ( Main/Merge ); précédent : 006653; suivant : 006655Selective loss of pyramidal neurons in the pre-supplementary motor cortex in Parkinson's disease
Auteurs : Virginia Macdonald [Australie] ; Glenda M. Halliday [Australie]Source :
- Movement disorders [ 0885-3185 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
The nonprimary motor cortices have not previously been studied in Parkinson's disease, despite the selective pattern of dysfunction observed in these regions. In particular, the presupplementary motor region is consistently underactive, with successful treatments correlating with increased excitatory drive to nonprimary motor regions. This finding could suggest a primary cortical abnormality in the presupplementary motor area (pre-SMA) in Parkinson's disease. We analysed and compared neuronal number in the pre-SMA and dorsolateral premotor cortical regions in 5 cases of Parkinson's disease and 5 controls. For each cortical region, the total neuronal number as well as the estimated numbers of subpopulations of interneurons and pyramidal neurons was quantified using previously published unbiased techniques. The results showed a significant loss of cortico-cortical projecting pyramidal neurons in the pre-SMA with no loss of other pyramidal neurons or interneurons either in this region or in the dorsolateral premotor region. These findings indicate a highly selective loss of pyramidal cells in the pre-SMA in Parkinson's disease, consistent with previous imaging findings in this disease. Our results implicate the degeneration of the premotor projection from the pre-SMA, along with dopaminergic basal ganglia dysfunction, in the pathogenesis of Parkinson's disease.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 002599
- to stream PascalFrancis, to step Curation: 000722
- to stream PascalFrancis, to step Checkpoint: 002615
Links to Exploration step
Pascal:03-0038696Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Selective loss of pyramidal neurons in the pre-supplementary motor cortex in Parkinson's disease</title><author><name sortKey="Macdonald, Virginia" sort="Macdonald, Virginia" uniqKey="Macdonald V" first="Virginia" last="Macdonald">Virginia Macdonald</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Prince of Wales Medical Research Institute and the University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Prince of Wales Medical Research Institute and the University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0038696</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 03-0038696 INIST</idno><idno type="RBID">Pascal:03-0038696</idno><idno type="wicri:Area/PascalFrancis/Corpus">002599</idno><idno type="wicri:Area/PascalFrancis/Curation">000722</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002615</idno><idno type="wicri:doubleKey">0885-3185:2002:Macdonald V:selective:loss:of</idno><idno type="wicri:Area/Main/Merge">006654</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Selective loss of pyramidal neurons in the pre-supplementary motor cortex in Parkinson's disease</title><author><name sortKey="Macdonald, Virginia" sort="Macdonald, Virginia" uniqKey="Macdonald V" first="Virginia" last="Macdonald">Virginia Macdonald</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Prince of Wales Medical Research Institute and the University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Prince of Wales Medical Research Institute and the University of New South Wales</s1><s2>Sydney</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Human</term><term>Parkinson disease</term><term>Pathology</term><term>Pathophysiology</term><term>Pyramidal neuron</term><term>Supplementary motor area</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Aire motrice supplémentaire</term><term>Neurone pyramidal</term><term>Anatomopathologie</term><term>Physiopathologie</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The nonprimary motor cortices have not previously been studied in Parkinson's disease, despite the selective pattern of dysfunction observed in these regions. In particular, the presupplementary motor region is consistently underactive, with successful treatments correlating with increased excitatory drive to nonprimary motor regions. This finding could suggest a primary cortical abnormality in the presupplementary motor area (pre-SMA) in Parkinson's disease. We analysed and compared neuronal number in the pre-SMA and dorsolateral premotor cortical regions in 5 cases of Parkinson's disease and 5 controls. For each cortical region, the total neuronal number as well as the estimated numbers of subpopulations of interneurons and pyramidal neurons was quantified using previously published unbiased techniques. The results showed a significant loss of cortico-cortical projecting pyramidal neurons in the pre-SMA with no loss of other pyramidal neurons or interneurons either in this region or in the dorsolateral premotor region. These findings indicate a highly selective loss of pyramidal cells in the pre-SMA in Parkinson's disease, consistent with previous imaging findings in this disease. Our results implicate the degeneration of the premotor projection from the pre-SMA, along with dopaminergic basal ganglia dysfunction, in the pathogenesis of Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Australie</li></country><settlement><li>Sydney</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Macdonald, Virginia" sort="Macdonald, Virginia" uniqKey="Macdonald V" first="Virginia" last="Macdonald">Virginia Macdonald</name></noRegion><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006654 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 006654 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Merge
|type= RBID
|clé= Pascal:03-0038696
|texte= Selective loss of pyramidal neurons in the pre-supplementary motor cortex in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |