Steele-Richardson-Olszewski syndrome: Reduction of dopamine D2 receptor binding relates to the severity of midbrain atrophy in vivo: 123IBZM SPECT and MRI study
Identifieur interne : 006644 ( Main/Merge ); précédent : 006643; suivant : 006645Steele-Richardson-Olszewski syndrome: Reduction of dopamine D2 receptor binding relates to the severity of midbrain atrophy in vivo: 123IBZM SPECT and MRI study
Auteurs : Guy Arnold [Allemagne] ; Klaus Tatsch [Allemagne] ; Eduardo Kraft [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Johannes Schwarz [Allemagne]Source :
- Movement disorders [ 0885-3185 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
Abstract
Patients with the clinical diagnosis of progressive supranuclear palsy (PSP) show heterogeneous neuropathological findings. In neuropathologically proven cases with numerous neurofibrillary tangles of neuropil threads, the brainstem and striatum are always affected. We compared 123I-iodobenzamide single photon emission computed tomography (IBZM-SPECT) for imaging of striatal dopamine D2 receptors in vivo with high-resolution magnetic resonance imaging (MRI) in 13 patients with possible or probable PSP. Clinically. all patients exhibited similar signs including supranuclear vertical-down-gaze palsy, axial rigidity especially involving the neck, bradykinesia, instability of balance with easy falls, and a poor response to dopaminergic drugs. Specific striatal dopamine D2 receptor binding in IBZM-SPECT was reduced in 10 patients but was normal in 3 patients. Mean midbrain diameter was 23.7 mm. The reduction of IBZM-binding was statistically significantly correlated to midbrain atrophy (P = 0.010) either in all 13 patients or in those without striatal or white matter lesions (P = 0.015). We suggest that technical investigations, mainly MRI, are able to corroborate the in vivo diagnosis, if PSP is clinically suspected.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Steele-Richardson-Olszewski syndrome: Reduction of dopamine D<sub>2</sub>
receptor binding relates to the severity of midbrain atrophy in vivo: <sup>123</sup>
IBZM SPECT and MRI study</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Steele-Richardson-Olszewski syndrome: Reduction of dopamine D<sub>2</sub>
receptor binding relates to the severity of midbrain atrophy in vivo: <sup>123</sup>
IBZM SPECT and MRI study</title>
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<author><name sortKey="Kraft, Eduardo" sort="Kraft, Eduardo" uniqKey="Kraft E" first="Eduardo" last="Kraft">Eduardo Kraft</name>
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<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
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<author><name sortKey="Schwarz, Johannes" sort="Schwarz, Johannes" uniqKey="Schwarz J" first="Johannes" last="Schwarz">Johannes Schwarz</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-Universität München</s1>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Antagonist</term>
<term>Atrophy</term>
<term>Benzamide derivatives</term>
<term>D2 Dopamine receptor</term>
<term>Diagnosis</term>
<term>In vivo</term>
<term>Morphometry</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Single photon emission tomography</term>
<term>Supranuclear ophthalmoplegia</term>
<term>Technique</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Ophtalmoplégie supranucléaire</term>
<term>Imagerie RMN</term>
<term>In vivo</term>
<term>Atrophie</term>
<term>Morphométrie</term>
<term>Tomoscintigraphie émission monophotonique</term>
<term>Benzamide dérivé</term>
<term>Récepteur dopaminergique D2</term>
<term>Antagoniste</term>
<term>Diagnostic</term>
<term>Technique</term>
<term>Adulte</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Patients with the clinical diagnosis of progressive supranuclear palsy (PSP) show heterogeneous neuropathological findings. In neuropathologically proven cases with numerous neurofibrillary tangles of neuropil threads, the brainstem and striatum are always affected. We compared <sup>123</sup>
I-iodobenzamide single photon emission computed tomography (IBZM-SPECT) for imaging of striatal dopamine D<sub>2</sub>
receptors in vivo with high-resolution magnetic resonance imaging (MRI) in 13 patients with possible or probable PSP. Clinically. all patients exhibited similar signs including supranuclear vertical-down-gaze palsy, axial rigidity especially involving the neck, bradykinesia, instability of balance with easy falls, and a poor response to dopaminergic drugs. Specific striatal dopamine D<sub>2</sub>
receptor binding in IBZM-SPECT was reduced in 10 patients but was normal in 3 patients. Mean midbrain diameter was 23.7 mm. The reduction of IBZM-binding was statistically significantly correlated to midbrain atrophy (P = 0.010) either in all 13 patients or in those without striatal or white matter lesions (P = 0.015). We suggest that technical investigations, mainly MRI, are able to corroborate the in vivo diagnosis, if PSP is clinically suspected.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
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<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Arnold, Guy" sort="Arnold, Guy" uniqKey="Arnold G" first="Guy" last="Arnold">Guy Arnold</name>
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<name sortKey="Kraft, Eduardo" sort="Kraft, Eduardo" uniqKey="Kraft E" first="Eduardo" last="Kraft">Eduardo Kraft</name>
<name sortKey="Kraft, Eduardo" sort="Kraft, Eduardo" uniqKey="Kraft E" first="Eduardo" last="Kraft">Eduardo Kraft</name>
<name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<name sortKey="Schwarz, Johannes" sort="Schwarz, Johannes" uniqKey="Schwarz J" first="Johannes" last="Schwarz">Johannes Schwarz</name>
<name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name>
<name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name>
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