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Steele-Richardson-Olszewski syndrome: Reduction of dopamine D2 receptor binding relates to the severity of midbrain atrophy in vivo: 123IBZM SPECT and MRI study

Identifieur interne : 006644 ( Main/Merge ); précédent : 006643; suivant : 006645

Steele-Richardson-Olszewski syndrome: Reduction of dopamine D2 receptor binding relates to the severity of midbrain atrophy in vivo: 123IBZM SPECT and MRI study

Auteurs : Guy Arnold [Allemagne] ; Klaus Tatsch [Allemagne] ; Eduardo Kraft [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Johannes Schwarz [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0367869

Descripteurs français

Pascal (Inist)
- Ophtalmoplégie supranucléaire, Imagerie RMN, In vivo, Atrophie, Morphométrie, Tomoscintigraphie émission monophotonique, Benzamide dérivé, Récepteur dopaminergique D2, Antagoniste, Diagnostic, Technique, Adulte.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Adult, Antagonist, Atrophy, Benzamide derivatives, D2 Dopamine receptor, Diagnosis, In vivo, Morphometry, Nuclear magnetic resonance imaging, Single photon emission tomography, Supranuclear ophthalmoplegia, Technique.

Abstract

Patients with the clinical diagnosis of progressive supranuclear palsy (PSP) show heterogeneous neuropathological findings. In neuropathologically proven cases with numerous neurofibrillary tangles of neuropil threads, the brainstem and striatum are always affected. We compared ¹²³I-iodobenzamide single photon emission computed tomography (IBZM-SPECT) for imaging of striatal dopamine D₂ receptors in vivo with high-resolution magnetic resonance imaging (MRI) in 13 patients with possible or probable PSP. Clinically. all patients exhibited similar signs including supranuclear vertical-down-gaze palsy, axial rigidity especially involving the neck, bradykinesia, instability of balance with easy falls, and a poor response to dopaminergic drugs. Specific striatal dopamine D₂ receptor binding in IBZM-SPECT was reduced in 10 patients but was normal in 3 patients. Mean midbrain diameter was 23.7 mm. The reduction of IBZM-binding was statistically significantly correlated to midbrain atrophy (P = 0.010) either in all 13 patients or in those without striatal or white matter lesions (P = 0.015). We suggest that technical investigations, mainly MRI, are able to corroborate the in vivo diagnosis, if PSP is clinically suspected.

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Pascal:02-0367869

Le document en format XML

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 receptor binding relates to the severity of midbrain atrophy in vivo: <sup>123</sup>
IBZM SPECT and MRI study</title>
<author><name sortKey="Arnold, Guy" sort="Arnold, Guy" uniqKey="Arnold G" first="Guy" last="Arnold">Guy Arnold</name>
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<author><name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name>
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<author><name sortKey="Schwarz, Johannes" sort="Schwarz, Johannes" uniqKey="Schwarz J" first="Johannes" last="Schwarz">Johannes Schwarz</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Steele-Richardson-Olszewski syndrome: Reduction of dopamine D<sub>2</sub>
 receptor binding relates to the severity of midbrain atrophy in vivo: <sup>123</sup>
IBZM SPECT and MRI study</title>
<author><name sortKey="Arnold, Guy" sort="Arnold, Guy" uniqKey="Arnold G" first="Guy" last="Arnold">Guy Arnold</name>
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<s2>München</s2>
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<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Radiology, Klinikum Grosshadern, Ludwig-Maximilians-Universität München</s1>
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<author><name sortKey="Kraft, Eduardo" sort="Kraft, Eduardo" uniqKey="Kraft E" first="Eduardo" last="Kraft">Eduardo Kraft</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-Universität München</s1>
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<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Radiology, Klinikum Grosshadern, Ludwig-Maximilians-Universität München</s1>
<s2>München</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<country>Allemagne</country>
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<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
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<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-Universität München</s1>
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<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Schwarz, Johannes" sort="Schwarz, Johannes" uniqKey="Schwarz J" first="Johannes" last="Schwarz">Johannes Schwarz</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-Universität München</s1>
<s2>München</s2>
<s3>DEU</s3>
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<region type="district" nuts="2">District de Haute-Bavière</region>
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</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
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<idno type="ISSN">0885-3185</idno>
<imprint><date when="2002">2002</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Antagonist</term>
<term>Atrophy</term>
<term>Benzamide derivatives</term>
<term>D2 Dopamine receptor</term>
<term>Diagnosis</term>
<term>In vivo</term>
<term>Morphometry</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Single photon emission tomography</term>
<term>Supranuclear ophthalmoplegia</term>
<term>Technique</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Ophtalmoplégie supranucléaire</term>
<term>Imagerie RMN</term>
<term>In vivo</term>
<term>Atrophie</term>
<term>Morphométrie</term>
<term>Tomoscintigraphie émission monophotonique</term>
<term>Benzamide dérivé</term>
<term>Récepteur dopaminergique D2</term>
<term>Antagoniste</term>
<term>Diagnostic</term>
<term>Technique</term>
<term>Adulte</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term>
</keywords>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Patients with the clinical diagnosis of progressive supranuclear palsy (PSP) show heterogeneous neuropathological findings. In neuropathologically proven cases with numerous neurofibrillary tangles of neuropil threads, the brainstem and striatum are always affected. We compared <sup>123</sup>
I-iodobenzamide single photon emission computed tomography (IBZM-SPECT) for imaging of striatal dopamine D<sub>2</sub>
 receptors in vivo with high-resolution magnetic resonance imaging (MRI) in 13 patients with possible or probable PSP. Clinically. all patients exhibited similar signs including supranuclear vertical-down-gaze palsy, axial rigidity especially involving the neck, bradykinesia, instability of balance with easy falls, and a poor response to dopaminergic drugs. Specific striatal dopamine D<sub>2</sub>
 receptor binding in IBZM-SPECT was reduced in 10 patients but was normal in 3 patients. Mean midbrain diameter was 23.7 mm. The reduction of IBZM-binding was statistically significantly correlated to midbrain atrophy (P = 0.010) either in all 13 patients or in those without striatal or white matter lesions (P = 0.015). We suggest that technical investigations, mainly MRI, are able to corroborate the in vivo diagnosis, if PSP is clinically suspected.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Bavière</li>
<li>District de Haute-Bavière</li>
</region>
<settlement><li>Munich</li>
</settlement>
<orgName><li>Université Louis-et-Maximilien de Munich</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Arnold, Guy" sort="Arnold, Guy" uniqKey="Arnold G" first="Guy" last="Arnold">Guy Arnold</name>
</region>
<name sortKey="Kraft, Eduardo" sort="Kraft, Eduardo" uniqKey="Kraft E" first="Eduardo" last="Kraft">Eduardo Kraft</name>
<name sortKey="Kraft, Eduardo" sort="Kraft, Eduardo" uniqKey="Kraft E" first="Eduardo" last="Kraft">Eduardo Kraft</name>
<name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<name sortKey="Schwarz, Johannes" sort="Schwarz, Johannes" uniqKey="Schwarz J" first="Johannes" last="Schwarz">Johannes Schwarz</name>
<name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name>
<name sortKey="Tatsch, Klaus" sort="Tatsch, Klaus" uniqKey="Tatsch K" first="Klaus" last="Tatsch">Klaus Tatsch</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Steele-Richardson-Olszewski syndrome: Reduction of dopamine D2 receptor binding relates to the severity of midbrain atrophy in vivo: 123IBZM SPECT and MRI study

Steele-Richardson-Olszewski syndrome: Reduction of dopamine D2 receptor binding relates to the severity of midbrain atrophy in vivo: 123IBZM SPECT and MRI study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri