MovDisordV3, Main, Merge, bibRecord, 006639

Sublingual atropine for sialorrhea secondary to parkinsonism: A pilot study

Identifieur interne : 006639 ( Main/Merge ); précédent : 006638; suivant : 006640

Sublingual atropine for sialorrhea secondary to parkinsonism: A pilot study

Auteurs : H. Christopher Hyson [Canada] ; Andrew M. Johnson [Canada] ; Mandar S. Jog [Canada]

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:03-0040823

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Sialorrhée, Atropine, Parasympatholytique, Voie sublinguale, Chimiothérapie, Traitement, Homme, Etude préalable.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Atropine, Chemotherapy, Human, Parasympatholytic, Parkinson disease, Previous study, Sialorrhea, Sublingual administration, Treatment.

Abstract

Sialorrhea is a relatively common symptom in idiopathic Parkinson's disease and related conditions for which most of the accepted treatments are either highly invasive or may cause substantial systemic side effects. This study describes an open-label pilot study of sublingual atropine drops for the treatment of sialorrhea in 7 patients (6 with Parkinson's disease, I with progressive supranuclear palsy). Participants demonstrated statistically significant declines in saliva production, both objectively and subjectively. Self-reported drooling severity showed a significant decline between baseline and 180 minutes, t(6) = 3.240 P < 0.025 (η² = 0.636), and between baseline and I week, t(6) = 4.583 P < 0.005 (η² = 0.778). Objectively measured saliva production decreased significantly between baseline and the 1-week follow-up, t(6) = 2.711 P < 0.05 (η² = 0.551). Delirium occurred in 1 patient (concurrent with a urinary tract infection), and 2 patients experienced worsening of hallucinations (active hallucinosis was concealed by both individuals to allow participation in the trial). The remaining trial participants did not experience any anticholinergic side effects. This trial shows that, in selected patient populations, sublingual atropine is a simple and inexpensive treatment for sialorrhea associated with parkinsonism.

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Pascal:03-0040823

Le document en format XML

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<author><name sortKey="Johnson, Andrew M" sort="Johnson, Andrew M" uniqKey="Johnson A" first="Andrew M." last="Johnson">Andrew M. Johnson</name>
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<author><name sortKey="Jog, Mandar S" sort="Jog, Mandar S" uniqKey="Jog M" first="Mandar S." last="Jog">Mandar S. Jog</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atropine</term>
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<term>Human</term>
<term>Parasympatholytic</term>
<term>Parkinson disease</term>
<term>Previous study</term>
<term>Sialorrhea</term>
<term>Sublingual administration</term>
<term>Treatment</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Sialorrhée</term>
<term>Atropine</term>
<term>Parasympatholytique</term>
<term>Voie sublinguale</term>
<term>Chimiothérapie</term>
<term>Traitement</term>
<term>Homme</term>
<term>Etude préalable</term>
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<front><div type="abstract" xml:lang="en">Sialorrhea is a relatively common symptom in idiopathic Parkinson's disease and related conditions for which most of the accepted treatments are either highly invasive or may cause substantial systemic side effects. This study describes an open-label pilot study of sublingual atropine drops for the treatment of sialorrhea in 7 patients (6 with Parkinson's disease, I with progressive supranuclear palsy). Participants demonstrated statistically significant declines in saliva production, both objectively and subjectively. Self-reported drooling severity showed a significant decline between baseline and 180 minutes, t(6) = 3.240 P < 0.025 (η<sup>2</sup>
 = 0.636), and between baseline and I week, t(6) = 4.583 P < 0.005 (η<sup>2</sup>
 = 0.778). Objectively measured saliva production decreased significantly between baseline and the 1-week follow-up, t(6) = 2.711 P < 0.05 (η<sup>2</sup>
 = 0.551). Delirium occurred in 1 patient (concurrent with a urinary tract infection), and 2 patients experienced worsening of hallucinations (active hallucinosis was concealed by both individuals to allow participation in the trial). The remaining trial participants did not experience any anticholinergic side effects. This trial shows that, in selected patient populations, sublingual atropine is a simple and inexpensive treatment for sialorrhea associated with parkinsonism.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
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<tree><country name="Canada"><noRegion><name sortKey="Hyson, H Christopher" sort="Hyson, H Christopher" uniqKey="Hyson H" first="H. Christopher" last="Hyson">H. Christopher Hyson</name>
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<name sortKey="Jog, Mandar S" sort="Jog, Mandar S" uniqKey="Jog M" first="Mandar S." last="Jog">Mandar S. Jog</name>
<name sortKey="Johnson, Andrew M" sort="Johnson, Andrew M" uniqKey="Johnson A" first="Andrew M." last="Johnson">Andrew M. Johnson</name>
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</tree>
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</record>

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	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Sublingual atropine for sialorrhea secondary to parkinsonism: A pilot study

Sublingual atropine for sialorrhea secondary to parkinsonism: A pilot study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri