Decreased phasic EMG activity during rapid eye movement sleep in treatment‐naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness
Identifieur interne : 006521 ( Main/Merge ); précédent : 006520; suivant : 006522Decreased phasic EMG activity during rapid eye movement sleep in treatment‐naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness
Auteurs : Diego Garcia-Borreguero [Espagne] ; Ana B. Caminero [Espagne] ; Yolanda De La Llave [Espagne] ; Oscar Larrosa [Espagne] ; Soledad Barrio [Espagne] ; Juan J. Granizo [Espagne] ; Juan A. Pareja [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-09.
English descriptors
- KwdEn :
- Aged, Dopamine Agonists (pharmacology), Dopamine Agonists (therapeutic use), Electromyography (drug effects), Female, Humans, Levodopa (pharmacology), Levodopa (therapeutic use), L‐dopa, Male, Movement Disorders (diagnosis), Muscle Tonus (drug effects), Parkinson Disease (drug therapy), Parkinson's disease, REM sleep, REM sleep behavior disorder, REM without atonia, Severity of Illness Index, Sleep, REM (drug effects), phasic twitching.
- MESH :
- chemical , pharmacology : Dopamine Agonists, Levodopa.
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- diagnosis : Movement Disorders.
- drug effects : Electromyography, Muscle Tonus, Sleep, REM.
- drug therapy : Parkinson Disease.
- Aged, Female, Humans, Male, Severity of Illness Index.
Abstract
Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently associated with Parkinson's disease (PD) and may anticipate its diagnosis by several years. We assessed the presence of motor dyscontrol during REM sleep in treatment‐naïve PD patients and investigated the putative effect of levodopa (L‐dopa) treatment on motor activity. Overnight sleep studies were performed on 15 previously untreated PD patients and 14 controls at baseline, again after a 3‐ to 9‐month treatment period with a low dose of L‐dopa, and 2 to 5 days after treatment discontinuation (in 8 patients). No differences in sleep parameters were observed across groups or treatment conditions. None of the patients met criteria for RBD at baseline, whereas 5 patients were symptomatic at the time of the second sleep study. A quantitative analysis of electromyographic (EMG) activity during REM sleep showed a lower phasic twitching activity in untreated PD than in controls. However, an increase in both phasic twitching and tonic activity was found after treatment with L‐dopa. Discontinuation of treatment resulted in a return to pretreatment values of phasic but not of tonic EMG activity. Thus, the increase in phasic activity seems to depend on the effects of L‐dopa, whereas the increase in tonic EMG activity during REM sleep might be caused by other factors such as the progression of disease. Potential implications for the understanding of the relationship between RBD and PD are discussed. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10233
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ISTEX:0DF90889100E323985C419C59144F579BB4B2DE7Le document en format XML
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Granizo</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department Epidemiology, Fundación Jiménez Diaz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Pareja, Juan A" sort="Pareja, Juan A" uniqKey="Pareja J" first="Juan A." last="Pareja">Juan A. Pareja</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Ruber Internacional, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-09">2002-09</date><biblScope unit="vol">17</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="934">934</biblScope><biblScope unit="page" to="941">941</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">0DF90889100E323985C419C59144F579BB4B2DE7</idno><idno type="DOI">10.1002/mds.10233</idno><idno type="ArticleID">MDS10233</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Dopamine Agonists (pharmacology)</term><term>Dopamine Agonists (therapeutic use)</term><term>Electromyography (drug effects)</term><term>Female</term><term>Humans</term><term>Levodopa (pharmacology)</term><term>Levodopa (therapeutic use)</term><term>L‐dopa</term><term>Male</term><term>Movement Disorders (diagnosis)</term><term>Muscle Tonus (drug effects)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson's disease</term><term>REM sleep</term><term>REM sleep behavior disorder</term><term>REM without atonia</term><term>Severity of Illness Index</term><term>Sleep, REM (drug effects)</term><term>phasic twitching</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Electromyography</term><term>Muscle Tonus</term><term>Sleep, REM</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Severity of Illness Index</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently associated with Parkinson's disease (PD) and may anticipate its diagnosis by several years. We assessed the presence of motor dyscontrol during REM sleep in treatment‐naïve PD patients and investigated the putative effect of levodopa (L‐dopa) treatment on motor activity. Overnight sleep studies were performed on 15 previously untreated PD patients and 14 controls at baseline, again after a 3‐ to 9‐month treatment period with a low dose of L‐dopa, and 2 to 5 days after treatment discontinuation (in 8 patients). No differences in sleep parameters were observed across groups or treatment conditions. None of the patients met criteria for RBD at baseline, whereas 5 patients were symptomatic at the time of the second sleep study. A quantitative analysis of electromyographic (EMG) activity during REM sleep showed a lower phasic twitching activity in untreated PD than in controls. However, an increase in both phasic twitching and tonic activity was found after treatment with L‐dopa. Discontinuation of treatment resulted in a return to pretreatment values of phasic but not of tonic EMG activity. Thus, the increase in phasic activity seems to depend on the effects of L‐dopa, whereas the increase in tonic EMG activity during REM sleep might be caused by other factors such as the progression of disease. Potential implications for the understanding of the relationship between RBD and PD are discussed. © 2002 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.10233"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Decreased phasic EMG activity during rapid eye movement sleep in treatment‐naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness</title><author><name sortKey="Garcia Orreguero, Diego" sort="Garcia Orreguero, Diego" uniqKey="Garcia Orreguero D" first="Diego" last="Garcia-Borreguero">Diego Garcia-Borreguero</name></author><author><name sortKey="Caminero, Ana B" sort="Caminero, Ana B" uniqKey="Caminero A" first="Ana B." last="Caminero">Ana B. Caminero</name></author><author><name sortKey="De La Llave, Yolanda" sort="De La Llave, Yolanda" uniqKey="De La Llave Y" first="Yolanda" last="De La Llave">Yolanda De La Llave</name></author><author><name sortKey="Larrosa, Oscar" sort="Larrosa, Oscar" uniqKey="Larrosa O" first="Oscar" last="Larrosa">Oscar Larrosa</name></author><author><name sortKey="Barrio, Soledad" sort="Barrio, Soledad" uniqKey="Barrio S" first="Soledad" last="Barrio">Soledad Barrio</name></author><author><name sortKey="Granizo, Juan J" sort="Granizo, Juan J" uniqKey="Granizo J" first="Juan J." last="Granizo">Juan J. Granizo</name></author><author><name sortKey="Pareja, Juan A" sort="Pareja, Juan A" uniqKey="Pareja J" first="Juan A." last="Pareja">Juan A. Pareja</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0DF90889100E323985C419C59144F579BB4B2DE7</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1002/mds.10233</idno><idno type="url">https://api.istex.fr/document/0DF90889100E323985C419C59144F579BB4B2DE7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000309</idno><idno type="wicri:Area/Istex/Curation">000309</idno><idno type="wicri:Area/Istex/Checkpoint">002E07</idno><idno type="wicri:doubleKey">0885-3185:2002:Garcia Orreguero D:decreased:phasic:emg</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Decreased phasic EMG activity during rapid eye movement sleep in treatment‐naïve Parkinson's disease: Effects of treatment with levodopa and progression of illness</title><author><name sortKey="Garcia Orreguero, Diego" sort="Garcia Orreguero, Diego" uniqKey="Garcia Orreguero D" first="Diego" last="Garcia-Borreguero">Diego Garcia-Borreguero</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Fundación Jiménez Diaz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Caminero, Ana B" sort="Caminero, Ana B" uniqKey="Caminero A" first="Ana B." last="Caminero">Ana B. Caminero</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Nuestra Señora de Sonsoles, Ávila</wicri:regionArea><wicri:noRegion>Ávila</wicri:noRegion></affiliation></author><author><name sortKey="De La Llave, Yolanda" sort="De La Llave, Yolanda" uniqKey="De La Llave Y" first="Yolanda" last="De La Llave">Yolanda De La Llave</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Fundación Jiménez Diaz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Larrosa, Oscar" sort="Larrosa, Oscar" uniqKey="Larrosa O" first="Oscar" last="Larrosa">Oscar Larrosa</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Fundación Jiménez Diaz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Barrio, Soledad" sort="Barrio, Soledad" uniqKey="Barrio S" first="Soledad" last="Barrio">Soledad Barrio</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Fundación Jiménez Diaz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Granizo, Juan J" sort="Granizo, Juan J" uniqKey="Granizo J" first="Juan J." last="Granizo">Juan J. Granizo</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department Epidemiology, Fundación Jiménez Diaz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Pareja, Juan A" sort="Pareja, Juan A" uniqKey="Pareja J" first="Juan A." last="Pareja">Juan A. Pareja</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Ruber Internacional, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-09">2002-09</date><biblScope unit="vol">17</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="934">934</biblScope><biblScope unit="page" to="941">941</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">0DF90889100E323985C419C59144F579BB4B2DE7</idno><idno type="DOI">10.1002/mds.10233</idno><idno type="ArticleID">MDS10233</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>L‐dopa</term><term>Parkinson's disease</term><term>REM sleep</term><term>REM sleep behavior disorder</term><term>REM without atonia</term><term>phasic twitching</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently associated with Parkinson's disease (PD) and may anticipate its diagnosis by several years. We assessed the presence of motor dyscontrol during REM sleep in treatment‐naïve PD patients and investigated the putative effect of levodopa (L‐dopa) treatment on motor activity. Overnight sleep studies were performed on 15 previously untreated PD patients and 14 controls at baseline, again after a 3‐ to 9‐month treatment period with a low dose of L‐dopa, and 2 to 5 days after treatment discontinuation (in 8 patients). No differences in sleep parameters were observed across groups or treatment conditions. None of the patients met criteria for RBD at baseline, whereas 5 patients were symptomatic at the time of the second sleep study. A quantitative analysis of electromyographic (EMG) activity during REM sleep showed a lower phasic twitching activity in untreated PD than in controls. However, an increase in both phasic twitching and tonic activity was found after treatment with L‐dopa. Discontinuation of treatment resulted in a return to pretreatment values of phasic but not of tonic EMG activity. Thus, the increase in phasic activity seems to depend on the effects of L‐dopa, whereas the increase in tonic EMG activity during REM sleep might be caused by other factors such as the progression of disease. Potential implications for the understanding of the relationship between RBD and PD are discussed. © 2002 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Decreased phasic EMG activity during rapid eye movement sleep in treatment-naïve Parkinson's disease: effects of treatment with levodopa and progression of illness.</title><author><name sortKey="Garcia Borreguero, Diego" sort="Garcia Borreguero, Diego" uniqKey="Garcia Borreguero D" first="Diego" last="Garcia-Borreguero">Diego Garcia-Borreguero</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Fundación Jiménez Diaz, Madrid, Spain. dgarciaborreguero@fjd.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Fundación Jiménez Diaz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Caminero, Ana B" sort="Caminero, Ana B" uniqKey="Caminero A" first="Ana B" last="Caminero">Ana B. Caminero</name></author><author><name sortKey="De La Llave, Yolanda" sort="De La Llave, Yolanda" uniqKey="De La Llave Y" first="Yolanda" last="De La Llave">Yolanda De La Llave</name></author><author><name sortKey="Larrosa, Oscar" sort="Larrosa, Oscar" uniqKey="Larrosa O" first="Oscar" last="Larrosa">Oscar Larrosa</name></author><author><name sortKey="Barrio, Soledad" sort="Barrio, Soledad" uniqKey="Barrio S" first="Soledad" last="Barrio">Soledad Barrio</name></author><author><name sortKey="Granizo, Juan J" sort="Granizo, Juan J" uniqKey="Granizo J" first="Juan J" last="Granizo">Juan J. Granizo</name></author><author><name sortKey="Pareja, Juan A" sort="Pareja, Juan A" uniqKey="Pareja J" first="Juan A" last="Pareja">Juan A. Pareja</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:12360542</idno><idno type="pmid">12360542</idno><idno type="doi">10.1002/mds.10233</idno><idno type="wicri:Area/PubMed/Corpus">003959</idno><idno type="wicri:Area/PubMed/Curation">003959</idno><idno type="wicri:Area/PubMed/Checkpoint">003B39</idno><idno type="wicri:Area/Ncbi/Merge">000892</idno><idno type="wicri:Area/Ncbi/Curation">000892</idno><idno type="wicri:Area/Ncbi/Checkpoint">000892</idno><idno type="wicri:doubleKey">0885-3185:2002:Garcia Borreguero D:decreased:phasic:emg</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Decreased phasic EMG activity during rapid eye movement sleep in treatment-naïve Parkinson's disease: effects of treatment with levodopa and progression of illness.</title><author><name sortKey="Garcia Borreguero, Diego" sort="Garcia Borreguero, Diego" uniqKey="Garcia Borreguero D" first="Diego" last="Garcia-Borreguero">Diego Garcia-Borreguero</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Fundación Jiménez Diaz, Madrid, Spain. dgarciaborreguero@fjd.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Fundación Jiménez Diaz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Caminero, Ana B" sort="Caminero, Ana B" uniqKey="Caminero A" first="Ana B" last="Caminero">Ana B. Caminero</name></author><author><name sortKey="De La Llave, Yolanda" sort="De La Llave, Yolanda" uniqKey="De La Llave Y" first="Yolanda" last="De La Llave">Yolanda De La Llave</name></author><author><name sortKey="Larrosa, Oscar" sort="Larrosa, Oscar" uniqKey="Larrosa O" first="Oscar" last="Larrosa">Oscar Larrosa</name></author><author><name sortKey="Barrio, Soledad" sort="Barrio, Soledad" uniqKey="Barrio S" first="Soledad" last="Barrio">Soledad Barrio</name></author><author><name sortKey="Granizo, Juan J" sort="Granizo, Juan J" uniqKey="Granizo J" first="Juan J" last="Granizo">Juan J. Granizo</name></author><author><name sortKey="Pareja, Juan A" sort="Pareja, Juan A" uniqKey="Pareja J" first="Juan A" last="Pareja">Juan A. Pareja</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Dopamine Agonists (pharmacology)</term><term>Dopamine Agonists (therapeutic use)</term><term>Electromyography (drug effects)</term><term>Female</term><term>Humans</term><term>Levodopa (pharmacology)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Movement Disorders (diagnosis)</term><term>Muscle Tonus (drug effects)</term><term>Parkinson Disease (drug therapy)</term><term>Severity of Illness Index</term><term>Sleep, REM (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Electromyography</term><term>Muscle Tonus</term><term>Sleep, REM</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rapid eye movement (REM) sleep behavior disorder (RBD) is frequently associated with Parkinson's disease (PD) and may anticipate its diagnosis by several years. We assessed the presence of motor dyscontrol during REM sleep in treatment-naïve PD patients and investigated the putative effect of levodopa (L-dopa) treatment on motor activity. Overnight sleep studies were performed on 15 previously untreated PD patients and 14 controls at baseline, again after a 3- to 9-month treatment period with a low dose of L-dopa, and 2 to 5 days after treatment discontinuation (in 8 patients). No differences in sleep parameters were observed across groups or treatment conditions. None of the patients met criteria for RBD at baseline, whereas 5 patients were symptomatic at the time of the second sleep study. A quantitative analysis of electromyographic (EMG) activity during REM sleep showed a lower phasic twitching activity in untreated PD than in controls. However, an increase in both phasic twitching and tonic activity was found after treatment with L-dopa. Discontinuation of treatment resulted in a return to pretreatment values of phasic but not of tonic EMG activity. Thus, the increase in phasic activity seems to depend on the effects of L-dopa, whereas the increase in tonic EMG activity during REM sleep might be caused by other factors such as the progression of disease. Potential implications for the understanding of the relationship between RBD and PD are discussed.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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