Effect of treatment with intravenous immunoglobulin on quality of life in patients with stiff‐person syndrome
Identifieur interne : 006488 ( Main/Merge ); précédent : 006487; suivant : 006489Effect of treatment with intravenous immunoglobulin on quality of life in patients with stiff‐person syndrome
Auteurs : Willibald Gerschlager [Royaume-Uni] ; Peter Brown [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-05.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Immunoglobulins, Intravenous.
- drug therapy : Stiff-Person Syndrome.
- psychology : Stiff-Person Syndrome.
- Aged, Female, Humans, Male, Middle Aged, Quality of Life, Questionnaires, Time Factors, Treatment Outcome.
Abstract
The therapeutic effects of intravenous immunoglobulin (IVIG) on the stiff‐person syndrome (SPS) have been described exclusively in case reports or open‐label studies in terms of clinical outcomes. We investigate whether IVIG improves quality of life (QoL) in the SPS. Six patients with the classic form of SPS completed a generic QoL instrument, the SF‐36, and a Visual Analogue Scale (VAS) before treatment as well as 2 weeks after completion of a course of IVIG. There was significant improvement in the SF‐36 subscores for pain, social functioning, general mental health, and energy–vitality with treatment. The VAS also improved significantly. We conclude that treatment with IVIG improves QoL in the SPS. © 2002 Movement Disorder Society.
Url:
DOI: 10.1002/mds.10043
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<front><div type="abstract" xml:lang="en">The therapeutic effects of intravenous immunoglobulin (IVIG) on the stiff‐person syndrome (SPS) have been described exclusively in case reports or open‐label studies in terms of clinical outcomes. We investigate whether IVIG improves quality of life (QoL) in the SPS. Six patients with the classic form of SPS completed a generic QoL instrument, the SF‐36, and a Visual Analogue Scale (VAS) before treatment as well as 2 weeks after completion of a course of IVIG. There was significant improvement in the SF‐36 subscores for pain, social functioning, general mental health, and energy–vitality with treatment. The VAS also improved significantly. We conclude that treatment with IVIG improves QoL in the SPS. © 2002 Movement Disorder Society.</div>
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<front><div type="abstract" xml:lang="en">The therapeutic effects of intravenous immunoglobulin (IVIG) on the stiff-person syndrome (SPS) have been described exclusively in case reports or open-label studies in terms of clinical outcomes. We investigate whether IVIG improves quality of life (QoL) in the SPS. Six patients with the classic form of SPS completed a generic QoL instrument, the SF-36, and a Visual Analogue Scale (VAS) before treatment as well as 2 weeks after completion of a course of IVIG. There was significant improvement in the SF-36 subscores for pain, social functioning, general mental health, and energy-vitality with treatment. The VAS also improved significantly. We conclude that treatment with IVIG improves QoL in the SPS.</div>
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