Evaluation of sleep and driving performance in six patients with Parkinson's disease reporting sudden onset of sleep under dopaminergic medication: A pilot study
Identifieur interne : 006473 ( Main/Merge ); précédent : 006472; suivant : 006474Evaluation of sleep and driving performance in six patients with Parkinson's disease reporting sudden onset of sleep under dopaminergic medication: A pilot study
Auteurs : J. Carsten Möller [Allemagne] ; Karin Stiasny [Allemagne] ; Volker Hargutt [Allemagne] ; Werner Cassel [Allemagne] ; Heiko Tietze [Allemagne] ; J. Hermann Peter [Allemagne] ; H. Eter Krüger [Allemagne] ; Wolfgang H. Oertel [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-05.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (adverse effects), Arousal (drug effects), Automobile Driving, Computer Simulation, Disorders of Excessive Somnolence (chemically induced), Dopamine Agonists (adverse effects), Female, Humans, Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (psychology), Pilot Projects, Polysomnography, Psychomotor Performance (drug effects), Reaction Time, Sleep (drug effects), daytime sleepiness, dopamine agonist, driving simulation, ergot, nonergoline, sudden onset of sleep.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Dopamine Agonists.
- chemically induced : Disorders of Excessive Somnolence.
- drug effects : Arousal, Psychomotor Performance, Sleep.
- drug therapy : Parkinson Disease.
- psychology : Parkinson Disease.
- Adult, Aged, Automobile Driving, Computer Simulation, Female, Humans, Male, Middle Aged, Pilot Projects, Polysomnography, Reaction Time.
Abstract
Six patients with Parkinson's disease (PD) reporting unusually fast or sudden onset of sleep under the addition of dopamine agonists to a previous levodopa‐containing therapy were examined using a sleep–wake diary, the Epworth sleepiness scale (ESS), polysomnography, multiple sleep latency tests (MSLT), a standardized vigilance test, and driving simulation. In all patients, ESS scores were increased and polysomnography showed disruption of the sleep pattern, a tendency towards poor sleep efficiency, and reduced proportions of slow‐ wave and rapid eye movement sleep. Pathological results in the MSLT or the vigilance test were obtained in five cases. For evaluation of driving performance, the standard deviation from the mean lane position during driving simulation was calculated. Three of five patients had clearly increased mean SDLP values. With respect to the measurement of daytime sleepiness (ESS, MSLT, vigilance test, and driving simulation), each patient had pathological results in at least two of these examinations. However, only a limited transfer of the routine vigilance assessment to driving performance was possible. In summary, this pilot study indicates that unusually fast or sudden onset of sleep in PD patients is a phenomenon of daytime sleepiness. © 2002 Movement Disorder Society.
Url:
DOI: 10.1002/mds.10020
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<front><div type="abstract" xml:lang="en">Six patients with Parkinson's disease (PD) reporting unusually fast or sudden onset of sleep under the addition of dopamine agonists to a previous levodopa‐containing therapy were examined using a sleep–wake diary, the Epworth sleepiness scale (ESS), polysomnography, multiple sleep latency tests (MSLT), a standardized vigilance test, and driving simulation. In all patients, ESS scores were increased and polysomnography showed disruption of the sleep pattern, a tendency towards poor sleep efficiency, and reduced proportions of slow‐ wave and rapid eye movement sleep. Pathological results in the MSLT or the vigilance test were obtained in five cases. For evaluation of driving performance, the standard deviation from the mean lane position during driving simulation was calculated. Three of five patients had clearly increased mean SDLP values. With respect to the measurement of daytime sleepiness (ESS, MSLT, vigilance test, and driving simulation), each patient had pathological results in at least two of these examinations. However, only a limited transfer of the routine vigilance assessment to driving performance was possible. In summary, this pilot study indicates that unusually fast or sudden onset of sleep in PD patients is a phenomenon of daytime sleepiness. © 2002 Movement Disorder Society.</div>
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<front><div type="abstract" xml:lang="en">Six patients with Parkinson's disease (PD) reporting unusually fast or sudden onset of sleep under the addition of dopamine agonists to a previous levodopa‐containing therapy were examined using a sleep–wake diary, the Epworth sleepiness scale (ESS), polysomnography, multiple sleep latency tests (MSLT), a standardized vigilance test, and driving simulation. In all patients, ESS scores were increased and polysomnography showed disruption of the sleep pattern, a tendency towards poor sleep efficiency, and reduced proportions of slow‐ wave and rapid eye movement sleep. Pathological results in the MSLT or the vigilance test were obtained in five cases. For evaluation of driving performance, the standard deviation from the mean lane position during driving simulation was calculated. Three of five patients had clearly increased mean SDLP values. With respect to the measurement of daytime sleepiness (ESS, MSLT, vigilance test, and driving simulation), each patient had pathological results in at least two of these examinations. However, only a limited transfer of the routine vigilance assessment to driving performance was possible. In summary, this pilot study indicates that unusually fast or sudden onset of sleep in PD patients is a phenomenon of daytime sleepiness. © 2002 Movement Disorder Society.</div>
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<author><name sortKey="Moller, J Carsten" sort="Moller, J Carsten" uniqKey="Moller J" first="J Carsten" last="Möller">J Carsten Möller</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany. moellerc@mailer.uni-marburg.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stiasny, Karin" sort="Stiasny, Karin" uniqKey="Stiasny K" first="Karin" last="Stiasny">Karin Stiasny</name>
</author>
<author><name sortKey="Hargutt, Volker" sort="Hargutt, Volker" uniqKey="Hargutt V" first="Volker" last="Hargutt">Volker Hargutt</name>
</author>
<author><name sortKey="Cassel, Werner" sort="Cassel, Werner" uniqKey="Cassel W" first="Werner" last="Cassel">Werner Cassel</name>
</author>
<author><name sortKey="Tietze, Heiko" sort="Tietze, Heiko" uniqKey="Tietze H" first="Heiko" last="Tietze">Heiko Tietze</name>
</author>
<author><name sortKey="Peter, J Hermann" sort="Peter, J Hermann" uniqKey="Peter J" first="J Hermann" last="Peter">J Hermann Peter</name>
</author>
<author><name sortKey="Kruger, H Peter" sort="Kruger, H Peter" uniqKey="Kruger H" first="H-Peter" last="Krüger">H-Peter Krüger</name>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2002">2002</date>
<idno type="RBID">pubmed:12112193</idno>
<idno type="pmid">12112193</idno>
<idno type="doi">10.1002/mds.10020</idno>
<idno type="wicri:Area/PubMed/Corpus">003A65</idno>
<idno type="wicri:Area/PubMed/Curation">003A65</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003A95</idno>
<idno type="wicri:Area/Ncbi/Merge">000786</idno>
<idno type="wicri:Area/Ncbi/Curation">000786</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000786</idno>
<idno type="wicri:doubleKey">0885-3185:2002:Moller J:evaluation:of:sleep</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Evaluation of sleep and driving performance in six patients with Parkinson's disease reporting sudden onset of sleep under dopaminergic medication: a pilot study.</title>
<author><name sortKey="Moller, J Carsten" sort="Moller, J Carsten" uniqKey="Moller J" first="J Carsten" last="Möller">J Carsten Möller</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Philipps University, Marburg, Germany. moellerc@mailer.uni-marburg.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stiasny, Karin" sort="Stiasny, Karin" uniqKey="Stiasny K" first="Karin" last="Stiasny">Karin Stiasny</name>
</author>
<author><name sortKey="Hargutt, Volker" sort="Hargutt, Volker" uniqKey="Hargutt V" first="Volker" last="Hargutt">Volker Hargutt</name>
</author>
<author><name sortKey="Cassel, Werner" sort="Cassel, Werner" uniqKey="Cassel W" first="Werner" last="Cassel">Werner Cassel</name>
</author>
<author><name sortKey="Tietze, Heiko" sort="Tietze, Heiko" uniqKey="Tietze H" first="Heiko" last="Tietze">Heiko Tietze</name>
</author>
<author><name sortKey="Peter, J Hermann" sort="Peter, J Hermann" uniqKey="Peter J" first="J Hermann" last="Peter">J Hermann Peter</name>
</author>
<author><name sortKey="Kruger, H Peter" sort="Kruger, H Peter" uniqKey="Kruger H" first="H-Peter" last="Krüger">H-Peter Krüger</name>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2002" type="published">2002</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Arousal (drug effects)</term>
<term>Automobile Driving</term>
<term>Computer Simulation</term>
<term>Disorders of Excessive Somnolence (chemically induced)</term>
<term>Dopamine Agonists (adverse effects)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (psychology)</term>
<term>Pilot Projects</term>
<term>Polysomnography</term>
<term>Psychomotor Performance (drug effects)</term>
<term>Reaction Time</term>
<term>Sleep (drug effects)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Dopamine Agonists</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Disorders of Excessive Somnolence</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Arousal</term>
<term>Psychomotor Performance</term>
<term>Sleep</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Automobile Driving</term>
<term>Computer Simulation</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pilot Projects</term>
<term>Polysomnography</term>
<term>Reaction Time</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Six patients with Parkinson's disease (PD) reporting unusually fast or sudden onset of sleep under the addition of dopamine agonists to a previous levodopa-containing therapy were examined using a sleep-wake diary, the Epworth sleepiness scale (ESS), polysomnography, multiple sleep latency tests (MSLT), a standardized vigilance test, and driving simulation. In all patients, ESS scores were increased and polysomnography showed disruption of the sleep pattern, a tendency towards poor sleep efficiency, and reduced proportions of slow- wave and rapid eye movement sleep. Pathological results in the MSLT or the vigilance test were obtained in five cases. For evaluation of driving performance, the standard deviation from the mean lane position during driving simulation was calculated. Three of five patients had clearly increased mean SDLP values. With respect to the measurement of daytime sleepiness (ESS, MSLT, vigilance test, and driving simulation), each patient had pathological results in at least two of these examinations. However, only a limited transfer of the routine vigilance assessment to driving performance was possible. In summary, this pilot study indicates that unusually fast or sudden onset of sleep in PD patients is a phenomenon of daytime sleepiness.</div>
</front>
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