Microstructure of the non‐rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: Effects of dopaminergic treatment
Identifieur interne : 006387 ( Main/Merge ); précédent : 006386; suivant : 006388Microstructure of the non‐rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: Effects of dopaminergic treatment
Auteurs : Hans Brunner [Allemagne] ; Thomas C. Wetter [Allemagne] ; Birgit Hogl [Allemagne] ; Alexander Yassouridis [Allemagne] ; Claudia Trenkwalder [Allemagne] ; Elisabeth Friess [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-09.
English descriptors
- KwdEn :
- Aged, Brain (physiopathology), Delta Rhythm, Dopamine Agonists (therapeutic use), Drug Therapy, Combination, EEG power spectrum, Electroencephalography, Electromyography, Ergolines (therapeutic use), Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson's disease, Polysomnography, Sleep, REM (physiology), Wakefulness (physiology), delta power, dopamine, non‐REM sleep, quantitative EEG.
- MESH :
- chemical , therapeutic use : Dopamine Agonists, Ergolines, Levodopa.
- drug therapy : Parkinson Disease.
- physiology : Sleep, REM, Wakefulness.
- physiopathology : Brain, Parkinson Disease.
- Aged, Delta Rhythm, Drug Therapy, Combination, Electroencephalography, Electromyography, Female, Humans, Male, Middle Aged, Polysomnography.
Abstract
We investigated non‐rapid eye movement (non‐REM) sleep in patients with newly diagnosed Parkinson's disease (PD) who had never previously received dopaminergic medication. There were no significant differences in the conventional sleep parameters between de novo patients with PD and a healthy control group, but the length of stage 1 sleep and the number of awakenings increased significantly upon administration of dopaminergic drugs. Analyzing the quantitative electroencephalogram (EEG), we observed a significant reduction in the low‐delta frequency range and a nonsignificant increase in the sigma frequency range in de novo patients with PD. The dopaminergic medication also nonsignificantly reduced the low‐delta and sigma frequencies, the latter to the level of the controls. Possible mechanisms that may account for the observed differences are discussed. It is suggested that Parkinson's disease as well as the application of dopaminergic drugs exerts a desynchronizing effect on the sleep EEG that is reflected in a disruption of sleep continuity. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10242
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ISTEX:BE46430DABD3481532E2E9F7435E565FF5CAC415Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-09">2002-09</date><biblScope unit="vol">17</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="928">928</biblScope><biblScope unit="page" to="933">933</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BE46430DABD3481532E2E9F7435E565FF5CAC415</idno><idno type="DOI">10.1002/mds.10242</idno><idno type="ArticleID">MDS10242</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain (physiopathology)</term><term>Delta Rhythm</term><term>Dopamine Agonists (therapeutic use)</term><term>Drug Therapy, Combination</term><term>EEG power spectrum</term><term>Electroencephalography</term><term>Electromyography</term><term>Ergolines (therapeutic use)</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson's disease</term><term>Polysomnography</term><term>Sleep, REM (physiology)</term><term>Wakefulness (physiology)</term><term>delta power</term><term>dopamine</term><term>non‐REM sleep</term><term>quantitative EEG</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term><term>Ergolines</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Sleep, REM</term><term>Wakefulness</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Delta Rhythm</term><term>Drug Therapy, Combination</term><term>Electroencephalography</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated non‐rapid eye movement (non‐REM) sleep in patients with newly diagnosed Parkinson's disease (PD) who had never previously received dopaminergic medication. There were no significant differences in the conventional sleep parameters between de novo patients with PD and a healthy control group, but the length of stage 1 sleep and the number of awakenings increased significantly upon administration of dopaminergic drugs. Analyzing the quantitative electroencephalogram (EEG), we observed a significant reduction in the low‐delta frequency range and a nonsignificant increase in the sigma frequency range in de novo patients with PD. The dopaminergic medication also nonsignificantly reduced the low‐delta and sigma frequencies, the latter to the level of the controls. Possible mechanisms that may account for the observed differences are discussed. It is suggested that Parkinson's disease as well as the application of dopaminergic drugs exerts a desynchronizing effect on the sleep EEG that is reflected in a disruption of sleep continuity. © 2002 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.10242"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Microstructure of the non‐rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: Effects of dopaminergic treatment</title><author><name sortKey="Brunner, Hans" sort="Brunner, Hans" uniqKey="Brunner H" first="Hans" last="Brunner">Hans Brunner</name></author><author><name sortKey="Wetter, Thomas C" sort="Wetter, Thomas C" uniqKey="Wetter T" first="Thomas C." last="Wetter">Thomas C. Wetter</name></author><author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Hogl">Birgit Hogl</name></author><author><name sortKey="Yassouridis, Alexander" sort="Yassouridis, Alexander" uniqKey="Yassouridis A" first="Alexander" last="Yassouridis">Alexander Yassouridis</name></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></author><author><name sortKey="Friess, Elisabeth" sort="Friess, Elisabeth" uniqKey="Friess E" first="Elisabeth" last="Friess">Elisabeth Friess</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BE46430DABD3481532E2E9F7435E565FF5CAC415</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1002/mds.10242</idno><idno type="url">https://api.istex.fr/document/BE46430DABD3481532E2E9F7435E565FF5CAC415/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001415</idno><idno type="wicri:Area/Istex/Curation">001415</idno><idno type="wicri:Area/Istex/Checkpoint">002C73</idno><idno type="wicri:doubleKey">0885-3185:2002:Brunner H:microstructure:of:the</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Microstructure of the non‐rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: Effects of dopaminergic treatment</title><author><name sortKey="Brunner, Hans" sort="Brunner, Hans" uniqKey="Brunner H" first="Hans" last="Brunner">Hans Brunner</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Wetter, Thomas C" sort="Wetter, Thomas C" uniqKey="Wetter T" first="Thomas C." last="Wetter">Thomas C. Wetter</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Hogl">Birgit Hogl</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Yassouridis, Alexander" sort="Yassouridis, Alexander" uniqKey="Yassouridis A" first="Alexander" last="Yassouridis">Alexander Yassouridis</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Friess, Elisabeth" sort="Friess, Elisabeth" uniqKey="Friess E" first="Elisabeth" last="Friess">Elisabeth Friess</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-09">2002-09</date><biblScope unit="vol">17</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="928">928</biblScope><biblScope unit="page" to="933">933</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BE46430DABD3481532E2E9F7435E565FF5CAC415</idno><idno type="DOI">10.1002/mds.10242</idno><idno type="ArticleID">MDS10242</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>EEG power spectrum</term><term>Parkinson's disease</term><term>delta power</term><term>dopamine</term><term>non‐REM sleep</term><term>quantitative EEG</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated non‐rapid eye movement (non‐REM) sleep in patients with newly diagnosed Parkinson's disease (PD) who had never previously received dopaminergic medication. There were no significant differences in the conventional sleep parameters between de novo patients with PD and a healthy control group, but the length of stage 1 sleep and the number of awakenings increased significantly upon administration of dopaminergic drugs. Analyzing the quantitative electroencephalogram (EEG), we observed a significant reduction in the low‐delta frequency range and a nonsignificant increase in the sigma frequency range in de novo patients with PD. The dopaminergic medication also nonsignificantly reduced the low‐delta and sigma frequencies, the latter to the level of the controls. Possible mechanisms that may account for the observed differences are discussed. It is suggested that Parkinson's disease as well as the application of dopaminergic drugs exerts a desynchronizing effect on the sleep EEG that is reflected in a disruption of sleep continuity. © 2002 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Microstructure of the non-rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: effects of dopaminergic treatment.</title><author><name sortKey="Brunner, Hans" sort="Brunner, Hans" uniqKey="Brunner H" first="Hans" last="Brunner">Hans Brunner</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute of Psychiatry, Munich, Germany. hbrunner@mpipsyk1.mpg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Wetter, Thomas C" sort="Wetter, Thomas C" uniqKey="Wetter T" first="Thomas C" last="Wetter">Thomas C. Wetter</name></author><author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Hogl">Birgit Hogl</name></author><author><name sortKey="Yassouridis, Alexander" sort="Yassouridis, Alexander" uniqKey="Yassouridis A" first="Alexander" last="Yassouridis">Alexander Yassouridis</name></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></author><author><name sortKey="Friess, Elisabeth" sort="Friess, Elisabeth" uniqKey="Friess E" first="Elisabeth" last="Friess">Elisabeth Friess</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:12360541</idno><idno type="pmid">12360541</idno><idno type="doi">10.1002/mds.10242</idno><idno type="wicri:Area/PubMed/Corpus">003960</idno><idno type="wicri:Area/PubMed/Curation">003960</idno><idno type="wicri:Area/PubMed/Checkpoint">003A18</idno><idno type="wicri:Area/Ncbi/Merge">000891</idno><idno type="wicri:Area/Ncbi/Curation">000891</idno><idno type="wicri:Area/Ncbi/Checkpoint">000891</idno><idno type="wicri:doubleKey">0885-3185:2002:Brunner H:microstructure:of:the</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Microstructure of the non-rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: effects of dopaminergic treatment.</title><author><name sortKey="Brunner, Hans" sort="Brunner, Hans" uniqKey="Brunner H" first="Hans" last="Brunner">Hans Brunner</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute of Psychiatry, Munich, Germany. hbrunner@mpipsyk1.mpg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Wetter, Thomas C" sort="Wetter, Thomas C" uniqKey="Wetter T" first="Thomas C" last="Wetter">Thomas C. Wetter</name></author><author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Hogl">Birgit Hogl</name></author><author><name sortKey="Yassouridis, Alexander" sort="Yassouridis, Alexander" uniqKey="Yassouridis A" first="Alexander" last="Yassouridis">Alexander Yassouridis</name></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></author><author><name sortKey="Friess, Elisabeth" sort="Friess, Elisabeth" uniqKey="Friess E" first="Elisabeth" last="Friess">Elisabeth Friess</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain (physiopathology)</term><term>Delta Rhythm</term><term>Dopamine Agonists (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Electroencephalography</term><term>Electromyography</term><term>Ergolines (therapeutic use)</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Polysomnography</term><term>Sleep, REM (physiology)</term><term>Wakefulness (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term><term>Ergolines</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Sleep, REM</term><term>Wakefulness</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Delta Rhythm</term><term>Drug Therapy, Combination</term><term>Electroencephalography</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated non-rapid eye movement (non-REM) sleep in patients with newly diagnosed Parkinson's disease (PD) who had never previously received dopaminergic medication. There were no significant differences in the conventional sleep parameters between de novo patients with PD and a healthy control group, but the length of stage 1 sleep and the number of awakenings increased significantly upon administration of dopaminergic drugs. Analyzing the quantitative electroencephalogram (EEG), we observed a significant reduction in the low-delta frequency range and a nonsignificant increase in the sigma frequency range in de novo patients with PD. The dopaminergic medication also nonsignificantly reduced the low-delta and sigma frequencies, the latter to the level of the controls. Possible mechanisms that may account for the observed differences are discussed. It is suggested that Parkinson's disease as well as the application of dopaminergic drugs exerts a desynchronizing effect on the sleep EEG that is reflected in a disruption of sleep continuity.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Microstructure of the non‐rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: Effects of dopaminergic treatment
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| This area was generated with Dilib version V0.6.23. |  |