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Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease

Identifieur interne : 005F74 ( Main/Merge ); précédent : 005F73; suivant : 005F75

Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease

Auteurs : Masataka Nishimura [Japon] ; Sadako Kuno [Japon] ; Ikuko Mizuta [Japon] ; Mitsuhiro Ohta [Japon] ; Hirofumi Maruyama [Japon] ; Ryuji Kaji [Japon] ; Hideshi Kawakami [Japon]

Source :

Movement disorders [ 0885-3185 ] ; 2003.

RBID : Pascal:04-0010854

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Sporadique, Polymorphisme, Génotype, Allèle, Protéine MCP1, Récepteur chimiokine CCR2, Gène, Facteur risque, Déterminisme génétique, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Allele, CCR2 chemokine receptor, Gene, Genetic determinism, Genotype, Human, Monocyte chemoattractant protein 1, Parkinson disease, Polymorphism, Risk factor, Sporadic.

Abstract

We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP-1) and CC chemokine receptor (CCR)-2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP-1 -2518A/G genotype affected the age-at-onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP-1 in PD.

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Pascal:04-0010854

Le document en format XML

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<author><name sortKey="Nishimura, Masataka" sort="Nishimura, Masataka" uniqKey="Nishimura M" first="Masataka" last="Nishimura">Masataka Nishimura</name>
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<author><name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease</title>
<author><name sortKey="Nishimura, Masataka" sort="Nishimura, Masataka" uniqKey="Nishimura M" first="Masataka" last="Nishimura">Masataka Nishimura</name>
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<author><name sortKey="Kuno, Sadako" sort="Kuno, Sadako" uniqKey="Kuno S" first="Sadako" last="Kuno">Sadako Kuno</name>
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<author><name sortKey="Mizuta, Ikuko" sort="Mizuta, Ikuko" uniqKey="Mizuta I" first="Ikuko" last="Mizuta">Ikuko Mizuta</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinical Research Center, Utano National Hospital</s1>
<s2>Kyoto</s2>
<s3>JPN</s3>
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<author><name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
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<imprint><date when="2003">2003</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Allele</term>
<term>CCR2 chemokine receptor</term>
<term>Gene</term>
<term>Genetic determinism</term>
<term>Genotype</term>
<term>Human</term>
<term>Monocyte chemoattractant protein 1</term>
<term>Parkinson disease</term>
<term>Polymorphism</term>
<term>Risk factor</term>
<term>Sporadic</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Sporadique</term>
<term>Polymorphisme</term>
<term>Génotype</term>
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<term>Protéine MCP1</term>
<term>Récepteur chimiokine CCR2</term>
<term>Gène</term>
<term>Facteur risque</term>
<term>Déterminisme génétique</term>
<term>Homme</term>
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<front><div type="abstract" xml:lang="en">We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP-1) and CC chemokine receptor (CCR)-2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP-1 -2518A/G genotype affected the age-at-onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP-1 in PD.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
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<tree><country name="Japon"><noRegion><name sortKey="Nishimura, Masataka" sort="Nishimura, Masataka" uniqKey="Nishimura M" first="Masataka" last="Nishimura">Masataka Nishimura</name>
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<name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name>
<name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name>
<name sortKey="Kuno, Sadako" sort="Kuno, Sadako" uniqKey="Kuno S" first="Sadako" last="Kuno">Sadako Kuno</name>
<name sortKey="Maruyama, Hirofumi" sort="Maruyama, Hirofumi" uniqKey="Maruyama H" first="Hirofumi" last="Maruyama">Hirofumi Maruyama</name>
<name sortKey="Mizuta, Ikuko" sort="Mizuta, Ikuko" uniqKey="Mizuta I" first="Ikuko" last="Mizuta">Ikuko Mizuta</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease

Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri