MovDisordV3, Main, Merge, bibRecord, 005E23

Visual function in Huntington's disease patients and presymptomatic gene carriers

Identifieur interne : 005E23 ( Main/Merge ); précédent : 005E22; suivant : 005E24

Visual function in Huntington's disease patients and presymptomatic gene carriers

Auteurs : Brian F. O'Donnell [États-Unis] ; Marcia A. Wilt [États-Unis] ; Ann Marie Hake [États-Unis] ; Julie C. Stout [États-Unis] ; Sandra C. Kirkwood [États-Unis] ; Tatiana Foroud [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2003.

RBID : Pascal:04-0051659

Descripteurs français

Pascal (Inist)
- Chorée Huntington, Vision, Perception visuelle, Asymptomatique, Mouvement, Exploration, Homme, Porteur sain.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Asymptomatic, Exploration, Human, Huntington disease, Motion, Vision, Visual perception.

Abstract

Disturbances of visual cognition, visuomotor performance, and visual memory have been described frequently in Huntington's disease (HD). Early stage visual abnormalities could contribute to these deficits. We evaluated visual processing in 20 control subjects who were non-gene carriers at risk for HD, nine presymptomatic gene-positive subjects, and eight subjects with a recent diagnosis of Huntington's disease. Visual perceptual tests of contrast sensitivity and motion discrimination were used to probe early stage visual processing. Extraocular movements were evaluated in a neurologic examination, and the Digit Symbol test was used to test visual motor performance. Contrast sensitivity did not differ among the three groups. Motion discrimination was impaired in HD subjects but not in the presymptomatic gene carriers when compared to gene noncarriers. Among gene carriers, impaired motion discrimination performance was associated with poorer Digit Symbol performance and extraocular abnormalities. These findings suggest that the early stages of HD are associated with disturbances of motion perception as well as disruptions of visual motor and ocular motor performance.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 002409
to stream PascalFrancis, to step Curation: 000912
to stream PascalFrancis, to step Checkpoint: 002277

Links to Exploration step

Pascal:04-0051659

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Visual function in Huntington's disease patients and presymptomatic gene carriers</title>
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<author><name sortKey="Wilt, Marcia A" sort="Wilt, Marcia A" uniqKey="Wilt M" first="Marcia A." last="Wilt">Marcia A. Wilt</name>
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<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asymptomatic</term>
<term>Exploration</term>
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<term>Huntington disease</term>
<term>Motion</term>
<term>Vision</term>
<term>Visual perception</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Chorée Huntington</term>
<term>Vision</term>
<term>Perception visuelle</term>
<term>Asymptomatique</term>
<term>Mouvement</term>
<term>Exploration</term>
<term>Homme</term>
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<front><div type="abstract" xml:lang="en">Disturbances of visual cognition, visuomotor performance, and visual memory have been described frequently in Huntington's disease (HD). Early stage visual abnormalities could contribute to these deficits. We evaluated visual processing in 20 control subjects who were non-gene carriers at risk for HD, nine presymptomatic gene-positive subjects, and eight subjects with a recent diagnosis of Huntington's disease. Visual perceptual tests of contrast sensitivity and motion discrimination were used to probe early stage visual processing. Extraocular movements were evaluated in a neurologic examination, and the Digit Symbol test was used to test visual motor performance. Contrast sensitivity did not differ among the three groups. Motion discrimination was impaired in HD subjects but not in the presymptomatic gene carriers when compared to gene noncarriers. Among gene carriers, impaired motion discrimination performance was associated with poorer Digit Symbol performance and extraocular abnormalities. These findings suggest that the early stages of HD are associated with disturbances of motion perception as well as disruptions of visual motor and ocular motor performance.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
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<tree><country name="États-Unis"><region name="Indiana"><name sortKey="O Donnell, Brian F" sort="O Donnell, Brian F" uniqKey="O Donnell B" first="Brian F." last="O'Donnell">Brian F. O'Donnell</name>
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<name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<name sortKey="Hake, Ann Marie" sort="Hake, Ann Marie" uniqKey="Hake A" first="Ann Marie" last="Hake">Ann Marie Hake</name>
<name sortKey="Kirkwood, Sandra C" sort="Kirkwood, Sandra C" uniqKey="Kirkwood S" first="Sandra C." last="Kirkwood">Sandra C. Kirkwood</name>
<name sortKey="Stout, Julie C" sort="Stout, Julie C" uniqKey="Stout J" first="Julie C." last="Stout">Julie C. Stout</name>
<name sortKey="Wilt, Marcia A" sort="Wilt, Marcia A" uniqKey="Wilt M" first="Marcia A." last="Wilt">Marcia A. Wilt</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Visual function in Huntington's disease patients and presymptomatic gene carriers

Visual function in Huntington's disease patients and presymptomatic gene carriers

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri