MovDisordV3, Main, Merge, bibRecord, 005A93

Alteration in α-synuclein mRNA expression in Parkinson's disease

Identifieur interne : 005A93 ( Main/Merge ); précédent : 005A92; suivant : 005A94

Alteration in α-synuclein mRNA expression in Parkinson's disease

Auteurs : Ann E. Kingsbury [Royaume-Uni] ; Susan E. Daniel [Royaume-Uni] ; Hardev Sangha [Royaume-Uni] ; Sarah Eisen [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Oliver J. F. Foster [Royaume-Uni]

Source :

Movement disorders [ 0885-3185 ] ; 2004.

RBID : Pascal:04-0364437

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Système nerveux pathologie.

English descriptors

KwdEn :
- Nervous system diseases, Parkinson disease.

Abstract

The presynaptic protein α-synuclein is considered to play an important role in the pathophysiology of Parkinson's disease (PD). Point mutations in the α-synuclein gene have been demonstrated in familial PD and α-synuclein is a major component of Lewy bodies, the pathological hallmark of the sporadic disease. It is not clear whether abnormal accumulation of α-synuclein is the result of abnormal levels of expression of the gene in neurodegenerative conditions. Expression of α-synuclein mRNA was therefore studied in control and PD brain using semiquantitative in situ hybridization. α-synuclein was expressed widely and hybridization signal was seen in most cortical regions, hippocampus, cerebellum, and brain stem. There was little mRNA in the striatum and no hybridization signal was detected in glia. High levels of α-synuclein mRNA expression in neurons did not seem to be a marker for Lewy body formation. Abundant signal was seen both in regions in which Lewy body deposition occurs commonly in idiopathic PD (PD), such as substantia nigra and frontal and temporal cortex, as well as in less susceptible regions, e.g. visual cortex. Quantitative comparison of mRNA expression in regions of predilection for Lewy body formation showed that mRNA expression was reduced significantly in melanized substantia nigra neurons and frontal cortex neurons in Parkinson's disease. In substantia nigra neurons there seemed to be a negative correlation between cellular mRNA expression and disease duration. These findings are in broad agreement with other studies of the expression of α-synuclein mRNA in human brain and suggest that Lewy body formation is unlikely to be the result of overexpression of α-synuclein.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 002171
to stream PascalFrancis, to step Curation: 000B50
to stream PascalFrancis, to step Checkpoint: 002255

Links to Exploration step

Pascal:04-0364437

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Alteration in α-synuclein mRNA expression in Parkinson's disease</title>
<author><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E." last="Kingsbury">Ann E. Kingsbury</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Queen Square Brain Bank for Neurological Disorders, Institute of Neurology</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Daniel, Susan E" sort="Daniel, Susan E" uniqKey="Daniel S" first="Susan E." last="Daniel">Susan E. Daniel</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Neurology</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sangha, Hardev" sort="Sangha, Hardev" uniqKey="Sangha H" first="Hardev" last="Sangha">Hardev Sangha</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Reta Lila Weston Institute of Neurological Studies, Royal Free and University College Medical School</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eisen, Sarah" sort="Eisen, Sarah" uniqKey="Eisen S" first="Sarah" last="Eisen">Sarah Eisen</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Royal Free and University College Medical School</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Reta Lila Weston Institute of Neurological Studies, Royal Free and University College Medical School</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName>National Hospital for Neurology and Neurosurgery</orgName>
</affiliation>
</author>
<author><name sortKey="Foster, Oliver J F" sort="Foster, Oliver J F" uniqKey="Foster O" first="Oliver J. F." last="Foster">Oliver J. F. Foster</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Neurology</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">04-0364437</idno>
<date when="2004">2004</date>
<idno type="stanalyst">PASCAL 04-0364437 INIST</idno>
<idno type="RBID">Pascal:04-0364437</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002171</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000B50</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002255</idno>
<idno type="wicri:doubleKey">0885-3185:2004:Kingsbury A:alteration:in:synuclein</idno>
<idno type="wicri:Area/Main/Merge">005A93</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Alteration in α-synuclein mRNA expression in Parkinson's disease</title>
<author><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E." last="Kingsbury">Ann E. Kingsbury</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Queen Square Brain Bank for Neurological Disorders, Institute of Neurology</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Daniel, Susan E" sort="Daniel, Susan E" uniqKey="Daniel S" first="Susan E." last="Daniel">Susan E. Daniel</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Neurology</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sangha, Hardev" sort="Sangha, Hardev" uniqKey="Sangha H" first="Hardev" last="Sangha">Hardev Sangha</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Reta Lila Weston Institute of Neurological Studies, Royal Free and University College Medical School</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eisen, Sarah" sort="Eisen, Sarah" uniqKey="Eisen S" first="Sarah" last="Eisen">Sarah Eisen</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Royal Free and University College Medical School</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Reta Lila Weston Institute of Neurological Studies, Royal Free and University College Medical School</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName>National Hospital for Neurology and Neurosurgery</orgName>
</affiliation>
</author>
<author><name sortKey="Foster, Oliver J F" sort="Foster, Oliver J F" uniqKey="Foster O" first="Oliver J. F." last="Foster">Oliver J. F. Foster</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Neurology</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Système nerveux pathologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The presynaptic protein α-synuclein is considered to play an important role in the pathophysiology of Parkinson's disease (PD). Point mutations in the α-synuclein gene have been demonstrated in familial PD and α-synuclein is a major component of Lewy bodies, the pathological hallmark of the sporadic disease. It is not clear whether abnormal accumulation of α-synuclein is the result of abnormal levels of expression of the gene in neurodegenerative conditions. Expression of α-synuclein mRNA was therefore studied in control and PD brain using semiquantitative in situ hybridization. α-synuclein was expressed widely and hybridization signal was seen in most cortical regions, hippocampus, cerebellum, and brain stem. There was little mRNA in the striatum and no hybridization signal was detected in glia. High levels of α-synuclein mRNA expression in neurons did not seem to be a marker for Lewy body formation. Abundant signal was seen both in regions in which Lewy body deposition occurs commonly in idiopathic PD (PD), such as substantia nigra and frontal and temporal cortex, as well as in less susceptible regions, e.g. visual cortex. Quantitative comparison of mRNA expression in regions of predilection for Lewy body formation showed that mRNA expression was reduced significantly in melanized substantia nigra neurons and frontal cortex neurons in Parkinson's disease. In substantia nigra neurons there seemed to be a negative correlation between cellular mRNA expression and disease duration. These findings are in broad agreement with other studies of the expression of α-synuclein mRNA in human brain and suggest that Lewy body formation is unlikely to be the result of overexpression of α-synuclein.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
<orgName><li>National Hospital for Neurology and Neurosurgery</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E." last="Kingsbury">Ann E. Kingsbury</name>
</region>
<name sortKey="Daniel, Susan E" sort="Daniel, Susan E" uniqKey="Daniel S" first="Susan E." last="Daniel">Susan E. Daniel</name>
<name sortKey="Eisen, Sarah" sort="Eisen, Sarah" uniqKey="Eisen S" first="Sarah" last="Eisen">Sarah Eisen</name>
<name sortKey="Foster, Oliver J F" sort="Foster, Oliver J F" uniqKey="Foster O" first="Oliver J. F." last="Foster">Oliver J. F. Foster</name>
<name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<name sortKey="Sangha, Hardev" sort="Sangha, Hardev" uniqKey="Sangha H" first="Hardev" last="Sangha">Hardev Sangha</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005A93 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 005A93 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     Pascal:04-0364437
   |texte=   Alteration in α-synuclein mRNA expression in Parkinson's disease
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Alteration in α-synuclein mRNA expression in Parkinson's disease

Alteration in α-synuclein mRNA expression in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri