Comparison of diffusion-weighted imaging and [123I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's disease
Identifieur interne : 005A35 ( Main/Merge ); précédent : 005A34; suivant : 005A36Comparison of diffusion-weighted imaging and [123I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's disease
Auteurs : Klaus Seppi [Autriche] ; Michael F. H. Schocke [Autriche] ; Eveline Donnemiller [Autriche] ; Regina Esterhammer [Autriche] ; Christian Kremser [Autriche] ; Christoph Scherfler [Autriche] ; Anja Diem [Autriche] ; Werner Jaschke [Autriche] ; Gregor K. Wenning [Autriche] ; Werner Poewe [Autriche]Source :
- Movement disorders [ 0885-3185 ] ; 2004.
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Abstract
Both dopamine D2 receptor (D2R) binding single-photon emission computed tomography (SPECT) with [123I]iodobenzamide (IBZM) and diffusion-weighted imaging (DWI) have been shown to contribute to the differential diagnosis of patients with the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD). We aimed to compare these two routinely available functional imaging modalities in differentiating patients with MSA-P from PD. For this purpose, results obtained by DWI and IBZM-SPECT were intraindividually compared in a cross-sectional study of 15 MSA-P and 17 PD patients matched for age and disease duration. The activity ratios of striatal to frontal cortex uptake (S/FC ratio) were used as a semiquantitative measure of the relative density of basal ganglia dopamine receptors labeled by IBZM. Regional apparent diffusion coefficients (rADC) were determined in the striatum. MSA-P patients had significantly lower S/FC ratios and significantly higher striatal rADCs than both PD patients and healthy volunteers. There were no significant differences in S/FC ratios and striatal rADC between PD patients and healthy volunteers. Sensitivity of IBZM-SPECT versus DWI for the differentiation of MSA-P from PD was 80% versus 93%, specificity 71% versus 100%, the predictive accuracy 75% versus 97%, the positive predictive value 71% versus 100%, and the negative predictive value 80% versus 94%. Striatal rADCs had a significant higher overall predictive accuracy than D2R binding with IBZM. In summary, our data suggest that DWI may be more accurate compared to IBZM-SPECT in the differential diagnosis of MSA-P versus PD.
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Wenning</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0069716</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 05-0069716 INIST</idno><idno type="RBID">Pascal:05-0069716</idno><idno type="wicri:Area/PascalFrancis/Corpus">001F99</idno><idno type="wicri:Area/PascalFrancis/Curation">000D22</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002197</idno><idno type="wicri:doubleKey">0885-3185:2004:Seppi K:comparison:of:diffusion</idno><idno type="wicri:Area/Main/Merge">005A35</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Comparison of diffusion-weighted imaging and [<sup>123</sup>I]IBZM-SPECT for the differentiation of patients with the Parkinson variant of multiple system atrophy from those with Parkinson's disease</title><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Schocke, Michael F H" sort="Schocke, Michael F H" uniqKey="Schocke M" first="Michael F. H." last="Schocke">Michael F. H. Schocke</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology, University of Innsbruck</s1><s2>Innsbruck, 3</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck, 3</wicri:noRegion></affiliation></author><author><name sortKey="Donnemiller, Eveline" sort="Donnemiller, Eveline" uniqKey="Donnemiller E" first="Eveline" last="Donnemiller">Eveline Donnemiller</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Nuclear Medicine, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>3 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Esterhammer, Regina" sort="Esterhammer, Regina" uniqKey="Esterhammer R" first="Regina" last="Esterhammer">Regina Esterhammer</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology, University of Innsbruck</s1><s2>Innsbruck, 3</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck, 3</wicri:noRegion></affiliation></author><author><name sortKey="Kremser, Christian" sort="Kremser, Christian" uniqKey="Kremser C" first="Christian" last="Kremser">Christian Kremser</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology, University of Innsbruck</s1><s2>Innsbruck, 3</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck, 3</wicri:noRegion></affiliation></author><author><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Diem, Anja" sort="Diem, Anja" uniqKey="Diem A" first="Anja" last="Diem">Anja Diem</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Jaschke, Werner" sort="Jaschke, Werner" uniqKey="Jaschke W" first="Werner" last="Jaschke">Werner Jaschke</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology, University of Innsbruck</s1><s2>Innsbruck, 3</s2><s3>AUT</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck, 3</wicri:noRegion></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University of Innsbruck</s1><s2>Innsbruck</s2><s3>AUT</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Innsbruck</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Comparative study</term><term>Diffusion imaging</term><term>Human</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Photon</term><term>Single photon emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Etude comparative</term><term>Tomoscintigraphie émission monophotonique</term><term>Atrophie multisystématisée</term><term>Photon</term><term>Homme</term><term>Parkinson maladie</term><term>Imagerie de diffusion</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Both dopamine D2 receptor (D2R) binding single-photon emission computed tomography (SPECT) with [<sup>123</sup>I]iodobenzamide (IBZM) and diffusion-weighted imaging (DWI) have been shown to contribute to the differential diagnosis of patients with the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD). We aimed to compare these two routinely available functional imaging modalities in differentiating patients with MSA-P from PD. For this purpose, results obtained by DWI and IBZM-SPECT were intraindividually compared in a cross-sectional study of 15 MSA-P and 17 PD patients matched for age and disease duration. The activity ratios of striatal to frontal cortex uptake (S/FC ratio) were used as a semiquantitative measure of the relative density of basal ganglia dopamine receptors labeled by IBZM. Regional apparent diffusion coefficients (rADC) were determined in the striatum. MSA-P patients had significantly lower S/FC ratios and significantly higher striatal rADCs than both PD patients and healthy volunteers. There were no significant differences in S/FC ratios and striatal rADC between PD patients and healthy volunteers. Sensitivity of IBZM-SPECT versus DWI for the differentiation of MSA-P from PD was 80% versus 93%, specificity 71% versus 100%, the predictive accuracy 75% versus 97%, the positive predictive value 71% versus 100%, and the negative predictive value 80% versus 94%. Striatal rADCs had a significant higher overall predictive accuracy than D2R binding with IBZM. In summary, our data suggest that DWI may be more accurate compared to IBZM-SPECT in the differential diagnosis of MSA-P versus PD.</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></noRegion><name sortKey="Diem, Anja" sort="Diem, Anja" uniqKey="Diem A" first="Anja" last="Diem">Anja Diem</name><name sortKey="Donnemiller, Eveline" sort="Donnemiller, Eveline" uniqKey="Donnemiller E" first="Eveline" last="Donnemiller">Eveline Donnemiller</name><name sortKey="Esterhammer, Regina" sort="Esterhammer, Regina" uniqKey="Esterhammer R" first="Regina" last="Esterhammer">Regina Esterhammer</name><name sortKey="Jaschke, Werner" sort="Jaschke, Werner" uniqKey="Jaschke W" first="Werner" last="Jaschke">Werner Jaschke</name><name sortKey="Kremser, Christian" sort="Kremser, Christian" uniqKey="Kremser C" first="Christian" last="Kremser">Christian Kremser</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><name sortKey="Schocke, Michael F H" sort="Schocke, Michael F H" uniqKey="Schocke M" first="Michael F. H." last="Schocke">Michael F. H. Schocke</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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