Drug adherence in Parkinson's disease
Identifieur interne : 005A07 ( Main/Merge ); précédent : 005A06; suivant : 005A08Drug adherence in Parkinson's disease
Auteurs : Norman A. Leopold [États-Unis] ; Marcia Polansky [États-Unis] ; Marcia R. Hurka [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2004.
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- Pascal (Inist)
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Abstract
Physicians modify drug schedules in response to their patients' clinical responses. Failure to relieve patients' symptoms or the emergence of drug-related side effects may reflect nonadherence to a prescribed drug schedule rather than incorrect therapeutic physician decisions. Using a medication questionnaire and a computerized medication event monitoring system (MEMS) to monitor medication use, nonadherence of drug use was examined in subjects with Parkinson's disease (PD). We report that prescription nonadherence in PD subjects was common and approximated that reported in other chronic diseases. During a 28-day observation period, only 4 of 39 subjects had complete schedule adherence, i.e., no missed, extra, or mistimed doses. Using a questionnaire, 24.3% of subjects acknowledged missing any doses but the computerized MEMS recorded that 51.3% of subjects missed at least one dose per week and 20.5% of subjects missed three or more doses per week. Mistiming of doses was admitted by 73% of subjects but 82.1% had recorded mistimed doses. Of multiple sociodemographic and disease-related items examined, only gender and level of education were statistically related to nonadherence.
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Leopold</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, Crozer-Chester Medical Center</s1><s2>Upland, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Polansky, Marcia" sort="Polansky, Marcia" uniqKey="Polansky M" first="Marcia" last="Polansky">Marcia Polansky</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Biostatistics, Drexel University College of Medicine</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hurka, Marcia R" sort="Hurka, Marcia R" uniqKey="Hurka M" first="Marcia R." last="Hurka">Marcia R. Hurka</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Nursing, Crozer-Chester Medical Center</s1><s2>Upland, Pennsylvania</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">04-0301828</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 04-0301828 INIST</idno><idno type="RBID">Pascal:04-0301828</idno><idno type="wicri:Area/PascalFrancis/Corpus">002192</idno><idno type="wicri:Area/PascalFrancis/Curation">000B29</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002169</idno><idno type="wicri:doubleKey">0885-3185:2004:Leopold N:drug:adherence:in</idno><idno type="wicri:Area/Main/Merge">005A07</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Drug adherence in Parkinson's disease</title><author><name sortKey="Leopold, Norman A" sort="Leopold, Norman A" uniqKey="Leopold N" first="Norman A." last="Leopold">Norman A. Leopold</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Neurology, Department of Medicine, Crozer-Chester Medical Center</s1><s2>Upland, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Polansky, Marcia" sort="Polansky, Marcia" uniqKey="Polansky M" first="Marcia" last="Polansky">Marcia Polansky</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Biostatistics, Drexel University College of Medicine</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hurka, Marcia R" sort="Hurka, Marcia R" uniqKey="Hurka M" first="Marcia R." last="Hurka">Marcia R. Hurka</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Nursing, Crozer-Chester Medical Center</s1><s2>Upland, Pennsylvania</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Système nerveux pathologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Physicians modify drug schedules in response to their patients' clinical responses. Failure to relieve patients' symptoms or the emergence of drug-related side effects may reflect nonadherence to a prescribed drug schedule rather than incorrect therapeutic physician decisions. Using a medication questionnaire and a computerized medication event monitoring system (MEMS) to monitor medication use, nonadherence of drug use was examined in subjects with Parkinson's disease (PD). We report that prescription nonadherence in PD subjects was common and approximated that reported in other chronic diseases. During a 28-day observation period, only 4 of 39 subjects had complete schedule adherence, i.e., no missed, extra, or mistimed doses. Using a questionnaire, 24.3% of subjects acknowledged missing any doses but the computerized MEMS recorded that 51.3% of subjects missed at least one dose per week and 20.5% of subjects missed three or more doses per week. Mistiming of doses was admitted by 73% of subjects but 82.1% had recorded mistimed doses. Of multiple sociodemographic and disease-related items examined, only gender and level of education were statistically related to nonadherence.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Leopold, Norman A" sort="Leopold, Norman A" uniqKey="Leopold N" first="Norman A." last="Leopold">Norman A. Leopold</name></region><name sortKey="Hurka, Marcia R" sort="Hurka, Marcia R" uniqKey="Hurka M" first="Marcia R." last="Hurka">Marcia R. Hurka</name><name sortKey="Polansky, Marcia" sort="Polansky, Marcia" uniqKey="Polansky M" first="Marcia" last="Polansky">Marcia Polansky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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