MovDisordV3, Main, Merge, bibRecord, 005A04

Effect of monoamine reuptake inhibitor NS 2330 in advanced Parkinson's disease

Identifieur interne : 005A04 ( Main/Merge ); précédent : 005A03; suivant : 005A05

Effect of monoamine reuptake inhibitor NS 2330 in advanced Parkinson's disease

Auteurs : William Bara-Jimenez [États-Unis] ; Tzvetelina Dimitrova [États-Unis] ; Abdulah Sherzai [États-Unis] ; Antonella Favit [États-Unis] ; M. M. Mouradian [États-Unis] ; Thomas N. Chase [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2004.

RBID : Pascal:04-0581918

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Inhibiteur recapture, Stade avancé, Parkinson maladie.

English descriptors

KwdEn :
- Advanced stage, Nervous system diseases, Parkinson disease, Reuptake inhibitor.

Abstract

Dopamine reuptake blockers, by enhancing and stabilizing intrasynaptic transmitter levels, could help palliate motor dysfunction in Parkinson's disease. This randomized, double-blind, placebo-controlled study compared the acute effects of the monoamine uptake inhibitor NS 2330 to those of placebo in 9 relatively advanced parkinsonian patients. At the dose administered, no change in parkinsonian scores was found when NS 2330 was given alone or with levodopa. Moreover, NS 2330 coadministration did not appear to alter dyskinesia severity or the duration of the antiparkinsonian response to levodopa. The drug was well tolerated. Under the conditions of this study, the present results failed to support the usefulness of dopamine reuptake inhibition in the treatment of advanced Parkinson's disease.

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Pascal:04-0581918

Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<term>Nervous system diseases</term>
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<term>Reuptake inhibitor</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">Dopamine reuptake blockers, by enhancing and stabilizing intrasynaptic transmitter levels, could help palliate motor dysfunction in Parkinson's disease. This randomized, double-blind, placebo-controlled study compared the acute effects of the monoamine uptake inhibitor NS 2330 to those of placebo in 9 relatively advanced parkinsonian patients. At the dose administered, no change in parkinsonian scores was found when NS 2330 was given alone or with levodopa. Moreover, NS 2330 coadministration did not appear to alter dyskinesia severity or the duration of the antiparkinsonian response to levodopa. The drug was well tolerated. Under the conditions of this study, the present results failed to support the usefulness of dopamine reuptake inhibition in the treatment of advanced Parkinson's disease.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
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<region><li>Maryland</li>
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<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Bara Jimenez, William" sort="Bara Jimenez, William" uniqKey="Bara Jimenez W" first="William" last="Bara-Jimenez">William Bara-Jimenez</name>
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<name sortKey="Chase, Thomas N" sort="Chase, Thomas N" uniqKey="Chase T" first="Thomas N." last="Chase">Thomas N. Chase</name>
<name sortKey="Dimitrova, Tzvetelina" sort="Dimitrova, Tzvetelina" uniqKey="Dimitrova T" first="Tzvetelina" last="Dimitrova">Tzvetelina Dimitrova</name>
<name sortKey="Favit, Antonella" sort="Favit, Antonella" uniqKey="Favit A" first="Antonella" last="Favit">Antonella Favit</name>
<name sortKey="Mouradian, M M" sort="Mouradian, M M" uniqKey="Mouradian M" first="M. M." last="Mouradian">M. M. Mouradian</name>
<name sortKey="Sherzai, Abdulah" sort="Sherzai, Abdulah" uniqKey="Sherzai A" first="Abdulah" last="Sherzai">Abdulah Sherzai</name>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Effect of monoamine reuptake inhibitor NS 2330 in advanced Parkinson's disease

Effect of monoamine reuptake inhibitor NS 2330 in advanced Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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