Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting “sleep attacks”
Identifieur interne : 005695 ( Main/Merge ); précédent : 005694; suivant : 005696Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting “sleep attacks”
Auteurs : Ida Rissling [Allemagne] ; Frank Geller [Allemagne] ; Oliver Bandmann [Allemagne] ; Karim Stiasny-Kolster [Allemagne] ; Yvonne Körner [Allemagne] ; Charlotte Meindorfner [Allemagne] ; Hans-Peter Krüger [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; J. Carsten Möller [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-11.
English descriptors
- KwdEn :
- Aged, Alleles, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Disorders of Excessive Somnolence (chemically induced), Disorders of Excessive Somnolence (genetics), Dopamine Agonists (adverse effects), Dopamine Agonists (therapeutic use), Female, Gene Frequency (genetics), Genetic Predisposition to Disease (genetics), Genotype, Humans, Male, Middle Aged, Narcolepsy (chemically induced), Narcolepsy (genetics), Parkinson Disease (drug therapy), Parkinson Disease (genetics), Parkinson's disease, Pilot Projects, Polymorphism, Genetic (drug effects), Polymorphism, Genetic (genetics), Receptors, Dopamine (drug effects), Receptors, Dopamine (genetics), Receptors, Dopamine D2 (drug effects), Receptors, Dopamine D2 (genetics), Receptors, Dopamine D3, Receptors, Dopamine D4, Risk Factors, dopamine receptor, polymorphism, sudden onset of sleep (SOS).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Dopamine Agonists.
- chemical , drug effects : Receptors, Dopamine, Receptors, Dopamine D2.
- chemical , genetics : Receptors, Dopamine, Receptors, Dopamine D2.
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agonists.
- chemically induced : Disorders of Excessive Somnolence, Narcolepsy.
- drug effects : Polymorphism, Genetic.
- drug therapy : Parkinson Disease.
- genetics : Disorders of Excessive Somnolence, Gene Frequency, Genetic Predisposition to Disease, Narcolepsy, Parkinson Disease, Polymorphism, Genetic.
- Aged, Alleles, Female, Genotype, Humans, Male, Middle Aged, Pilot Projects, Receptors, Dopamine D3, Receptors, Dopamine D4, Risk Factors.
Abstract
Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of “sleep attacks” in PD was observed. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20245
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<front><div type="abstract" xml:lang="en">Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of “sleep attacks” in PD was observed. © 2004 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of “sleep attacks” in PD was observed. © 2004 Movement Disorder Society</div>
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<term>Disorders of Excessive Somnolence (genetics)</term>
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<front><div type="abstract" xml:lang="en">Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of "sleep attacks" in PD was observed.</div>
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