Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting “sleep attacks”
Identifieur interne : 005695 ( Main/Merge ); précédent : 005694; suivant : 005696Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting “sleep attacks”
Auteurs : Ida Rissling [Allemagne] ; Frank Geller [Allemagne] ; Oliver Bandmann [Allemagne] ; Karim Stiasny-Kolster [Allemagne] ; Yvonne Körner [Allemagne] ; Charlotte Meindorfner [Allemagne] ; Hans-Peter Krüger [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; J. Carsten Möller [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-11.
English descriptors
- KwdEn :
- Aged, Alleles, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Disorders of Excessive Somnolence (chemically induced), Disorders of Excessive Somnolence (genetics), Dopamine Agonists (adverse effects), Dopamine Agonists (therapeutic use), Female, Gene Frequency (genetics), Genetic Predisposition to Disease (genetics), Genotype, Humans, Male, Middle Aged, Narcolepsy (chemically induced), Narcolepsy (genetics), Parkinson Disease (drug therapy), Parkinson Disease (genetics), Parkinson's disease, Pilot Projects, Polymorphism, Genetic (drug effects), Polymorphism, Genetic (genetics), Receptors, Dopamine (drug effects), Receptors, Dopamine (genetics), Receptors, Dopamine D2 (drug effects), Receptors, Dopamine D2 (genetics), Receptors, Dopamine D3, Receptors, Dopamine D4, Risk Factors, dopamine receptor, polymorphism, sudden onset of sleep (SOS).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Dopamine Agonists.
- chemical , drug effects : Receptors, Dopamine, Receptors, Dopamine D2.
- chemical , genetics : Receptors, Dopamine, Receptors, Dopamine D2.
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agonists.
- chemically induced : Disorders of Excessive Somnolence, Narcolepsy.
- drug effects : Polymorphism, Genetic.
- drug therapy : Parkinson Disease.
- genetics : Disorders of Excessive Somnolence, Gene Frequency, Genetic Predisposition to Disease, Narcolepsy, Parkinson Disease, Polymorphism, Genetic.
- Aged, Alleles, Female, Genotype, Humans, Male, Middle Aged, Pilot Projects, Receptors, Dopamine D3, Receptors, Dopamine D4, Risk Factors.
Abstract
Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of “sleep attacks” in PD was observed. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20245
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-11">2004-11</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1279">1279</biblScope><biblScope unit="page" to="1284">1284</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BEA102F3C54657BD0F7E28B966D297CDE67C9B9A</idno><idno type="DOI">10.1002/mds.20245</idno><idno type="ArticleID">MDS20245</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Antiparkinson Agents (adverse effects)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Disorders of Excessive Somnolence (chemically induced)</term><term>Disorders of Excessive Somnolence (genetics)</term><term>Dopamine Agonists (adverse effects)</term><term>Dopamine Agonists (therapeutic use)</term><term>Female</term><term>Gene Frequency (genetics)</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Narcolepsy (chemically induced)</term><term>Narcolepsy (genetics)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (genetics)</term><term>Parkinson's disease</term><term>Pilot Projects</term><term>Polymorphism, Genetic (drug effects)</term><term>Polymorphism, Genetic (genetics)</term><term>Receptors, Dopamine (drug effects)</term><term>Receptors, Dopamine (genetics)</term><term>Receptors, Dopamine D2 (drug effects)</term><term>Receptors, Dopamine D2 (genetics)</term><term>Receptors, Dopamine D3</term><term>Receptors, Dopamine D4</term><term>Risk Factors</term><term>dopamine receptor</term><term>polymorphism</term><term>sudden onset of sleep (SOS)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, Dopamine</term><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Dopamine</term><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Disorders of Excessive Somnolence</term><term>Narcolepsy</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Disorders of Excessive Somnolence</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Narcolepsy</term><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term><term>Receptors, Dopamine D3</term><term>Receptors, Dopamine D4</term><term>Risk Factors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of “sleep attacks” in PD was observed. © 2004 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.20245"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting “sleep attacks”</title><author><name sortKey="Rissling, Ida" sort="Rissling, Ida" uniqKey="Rissling I" first="Ida" last="Rissling">Ida Rissling</name></author><author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name></author><author><name sortKey="Bandmann, Oliver" sort="Bandmann, Oliver" uniqKey="Bandmann O" first="Oliver" last="Bandmann">Oliver Bandmann</name></author><author><name sortKey="Stiasny Olster, Karim" sort="Stiasny Olster, Karim" uniqKey="Stiasny Olster K" first="Karim" last="Stiasny-Kolster">Karim Stiasny-Kolster</name></author><author><name sortKey="Korner, Yvonne" sort="Korner, Yvonne" uniqKey="Korner Y" first="Yvonne" last="Körner">Yvonne Körner</name></author><author><name sortKey="Meindorfner, Charlotte" sort="Meindorfner, Charlotte" uniqKey="Meindorfner C" first="Charlotte" last="Meindorfner">Charlotte Meindorfner</name></author><author><name sortKey="Kruger, Hans Eter" sort="Kruger, Hans Eter" uniqKey="Kruger H" first="Hans-Peter" last="Krüger">Hans-Peter Krüger</name></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name></author><author><name sortKey="Moller, J Carsten" sort="Moller, J Carsten" uniqKey="Moller J" first="J. Carsten" last="Möller">J. Carsten Möller</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BEA102F3C54657BD0F7E28B966D297CDE67C9B9A</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1002/mds.20245</idno><idno type="url">https://api.istex.fr/document/BEA102F3C54657BD0F7E28B966D297CDE67C9B9A/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001F44</idno><idno type="wicri:Area/Istex/Curation">001F44</idno><idno type="wicri:Area/Istex/Checkpoint">002718</idno><idno type="wicri:doubleKey">0885-3185:2004:Rissling I:dopamine:receptor:gene</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting “sleep attacks”</title><author><name sortKey="Rissling, Ida" sort="Rissling, Ida" uniqKey="Rissling I" first="Ida" last="Rissling">Ida Rissling</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University Marburg</wicri:regionArea><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg</wicri:regionArea><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Bandmann, Oliver" sort="Bandmann, Oliver" uniqKey="Bandmann O" first="Oliver" last="Bandmann">Oliver Bandmann</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University Marburg</wicri:regionArea><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Stiasny Olster, Karim" sort="Stiasny Olster, Karim" uniqKey="Stiasny Olster K" first="Karim" last="Stiasny-Kolster">Karim Stiasny-Kolster</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University Marburg</wicri:regionArea><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Korner, Yvonne" sort="Korner, Yvonne" uniqKey="Korner Y" first="Yvonne" last="Körner">Yvonne Körner</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Traffic Sciences, Department of Psychology, Julius‐Maximilians‐University Würzburg</wicri:regionArea><wicri:noRegion>Julius‐Maximilians‐University Würzburg</wicri:noRegion><wicri:noRegion>Julius‐Maximilians‐University Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Meindorfner, Charlotte" sort="Meindorfner, Charlotte" uniqKey="Meindorfner C" first="Charlotte" last="Meindorfner">Charlotte Meindorfner</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Traffic Sciences, Department of Psychology, Julius‐Maximilians‐University Würzburg</wicri:regionArea><wicri:noRegion>Julius‐Maximilians‐University Würzburg</wicri:noRegion><wicri:noRegion>Julius‐Maximilians‐University Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Kruger, Hans Eter" sort="Kruger, Hans Eter" uniqKey="Kruger H" first="Hans-Peter" last="Krüger">Hans-Peter Krüger</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Traffic Sciences, Department of Psychology, Julius‐Maximilians‐University Würzburg</wicri:regionArea><wicri:noRegion>Julius‐Maximilians‐University Würzburg</wicri:noRegion><wicri:noRegion>Julius‐Maximilians‐University Würzburg</wicri:noRegion></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University Marburg</wicri:regionArea><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Moller, J Carsten" sort="Moller, J Carsten" uniqKey="Moller J" first="J. Carsten" last="Möller">J. Carsten Möller</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University Marburg</wicri:regionArea><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion><wicri:noRegion>Philipps‐University Marburg</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-11">2004-11</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1279">1279</biblScope><biblScope unit="page" to="1284">1284</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BEA102F3C54657BD0F7E28B966D297CDE67C9B9A</idno><idno type="DOI">10.1002/mds.20245</idno><idno type="ArticleID">MDS20245</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dopamine receptor</term><term>polymorphism</term><term>sudden onset of sleep (SOS)</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of “sleep attacks” in PD was observed. © 2004 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting "sleep attacks".</title><author><name sortKey="Rissling, Ida" sort="Rissling, Ida" uniqKey="Rissling I" first="Ida" last="Rissling">Ida Rissling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Philipps-University Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps-University Marburg</wicri:regionArea><wicri:noRegion>Philipps-University Marburg</wicri:noRegion><wicri:noRegion>Philipps-University Marburg</wicri:noRegion><wicri:noRegion>Philipps-University Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name></author><author><name sortKey="Bandmann, Oliver" sort="Bandmann, Oliver" uniqKey="Bandmann O" first="Oliver" last="Bandmann">Oliver Bandmann</name></author><author><name sortKey="Stiasny Kolster, Karim" sort="Stiasny Kolster, Karim" uniqKey="Stiasny Kolster K" first="Karim" last="Stiasny-Kolster">Karim Stiasny-Kolster</name></author><author><name sortKey="Korner, Yvonne" sort="Korner, Yvonne" uniqKey="Korner Y" first="Yvonne" last="Körner">Yvonne Körner</name></author><author><name sortKey="Meindorfner, Charlotte" sort="Meindorfner, Charlotte" uniqKey="Meindorfner C" first="Charlotte" last="Meindorfner">Charlotte Meindorfner</name></author><author><name sortKey="Kruger, Hans Peter" sort="Kruger, Hans Peter" uniqKey="Kruger H" first="Hans-Peter" last="Krüger">Hans-Peter Krüger</name></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name></author><author><name sortKey="Moller, J Carsten" sort="Moller, J Carsten" uniqKey="Moller J" first="J Carsten" last="Möller">J Carsten Möller</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15390060</idno><idno type="pmid">15390060</idno><idno type="doi">10.1002/mds.20245</idno><idno type="wicri:Area/PubMed/Corpus">003253</idno><idno type="wicri:Area/PubMed/Curation">003253</idno><idno type="wicri:Area/PubMed/Checkpoint">003483</idno><idno type="wicri:Area/Ncbi/Merge">001035</idno><idno type="wicri:Area/Ncbi/Curation">001035</idno><idno type="wicri:Area/Ncbi/Checkpoint">001035</idno><idno type="wicri:doubleKey">0885-3185:2004:Rissling I:dopamine:receptor:gene</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting "sleep attacks".</title><author><name sortKey="Rissling, Ida" sort="Rissling, Ida" uniqKey="Rissling I" first="Ida" last="Rissling">Ida Rissling</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Philipps-University Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps-University Marburg</wicri:regionArea><wicri:noRegion>Philipps-University Marburg</wicri:noRegion><wicri:noRegion>Philipps-University Marburg</wicri:noRegion><wicri:noRegion>Philipps-University Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Geller, Frank" sort="Geller, Frank" uniqKey="Geller F" first="Frank" last="Geller">Frank Geller</name></author><author><name sortKey="Bandmann, Oliver" sort="Bandmann, Oliver" uniqKey="Bandmann O" first="Oliver" last="Bandmann">Oliver Bandmann</name></author><author><name sortKey="Stiasny Kolster, Karim" sort="Stiasny Kolster, Karim" uniqKey="Stiasny Kolster K" first="Karim" last="Stiasny-Kolster">Karim Stiasny-Kolster</name></author><author><name sortKey="Korner, Yvonne" sort="Korner, Yvonne" uniqKey="Korner Y" first="Yvonne" last="Körner">Yvonne Körner</name></author><author><name sortKey="Meindorfner, Charlotte" sort="Meindorfner, Charlotte" uniqKey="Meindorfner C" first="Charlotte" last="Meindorfner">Charlotte Meindorfner</name></author><author><name sortKey="Kruger, Hans Peter" sort="Kruger, Hans Peter" uniqKey="Kruger H" first="Hans-Peter" last="Krüger">Hans-Peter Krüger</name></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name></author><author><name sortKey="Moller, J Carsten" sort="Moller, J Carsten" uniqKey="Moller J" first="J Carsten" last="Möller">J Carsten Möller</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Antiparkinson Agents (adverse effects)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Disorders of Excessive Somnolence (chemically induced)</term><term>Disorders of Excessive Somnolence (genetics)</term><term>Dopamine Agonists (adverse effects)</term><term>Dopamine Agonists (therapeutic use)</term><term>Female</term><term>Gene Frequency (genetics)</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Narcolepsy (chemically induced)</term><term>Narcolepsy (genetics)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (genetics)</term><term>Pilot Projects</term><term>Polymorphism, Genetic (drug effects)</term><term>Polymorphism, Genetic (genetics)</term><term>Receptors, Dopamine (drug effects)</term><term>Receptors, Dopamine (genetics)</term><term>Receptors, Dopamine D2 (drug effects)</term><term>Receptors, Dopamine D2 (genetics)</term><term>Receptors, Dopamine D3</term><term>Receptors, Dopamine D4</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, Dopamine</term><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Dopamine</term><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Disorders of Excessive Somnolence</term><term>Narcolepsy</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Disorders of Excessive Somnolence</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Narcolepsy</term><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Alleles</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term><term>Receptors, Dopamine D3</term><term>Receptors, Dopamine D4</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genes encoding proteins involved in dopaminergic transmission are potential candidate genes for the induction of somnolence in Parkinson's disease (PD) because dopaminergic agents have been shown to be associated with sudden onset of sleep (SOS) in PD. We conducted an association study on dopamine D2, D3, and D4 receptor gene polymorphisms comparing 137 PD patients with SOS and 137 PD patients without SOS matched according to drug therapy, disease duration, sex, and age. Our results show a significant association between the dopamine D2 receptor gene polymorphism Taq IA and SOS in PD. No significant association between two other investigated polymorphisms and the phenomenon of "sleep attacks" in PD was observed.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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