L‐dopa–responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings
Identifieur interne : 005621 ( Main/Merge ); précédent : 005620; suivant : 005622L‐dopa–responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings
Auteurs : Andrew H. Evans [Royaume-Uni] ; Durval C. Costa ; Sveto Gacinovic [Royaume-Uni] ; Regina Katzenschlager [Royaume-Uni] ; John D. O'Sullivan [Australie] ; Simon Heales [Royaume-Uni] ; Phillip Lee [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-10.
English descriptors
- KwdEn :
- Adult, Antiparkinson Agents (therapeutic use), Benzamides (diagnostic use), Brain (blood supply), Brain (radionuclide imaging), Dopamine Plasma Membrane Transport Proteins, Female, Humans, Iodine Radioisotopes (diagnostic use), Levodopa (therapeutic use), Membrane Glycoproteins (metabolism), Membrane Transport Proteins (metabolism), Nerve Tissue Proteins (metabolism), PKU, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (metabolism), Phenylketonurias (complications), Pyrrolidines (diagnostic use), Radiopharmaceuticals (diagnostic use), Receptors, Dopamine D2 (metabolism), Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use), parkinsonism, single‐photon emission computed tomography.
- MESH :
- chemical , diagnostic use : Benzamides, Iodine Radioisotopes, Pyrrolidines, Radiopharmaceuticals, Tropanes.
- chemical , metabolism : Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Receptors, Dopamine D2.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- blood supply : Brain.
- complications : Parkinson Disease, Phenylketonurias.
- drug therapy : Parkinson Disease.
- metabolism : Parkinson Disease.
- radionuclide imaging : Brain.
- Adult, Dopamine Plasma Membrane Transport Proteins, Female, Humans, Tomography, Emission-Computed, Single-Photon.
Abstract
Reports of parkinsonism in phenylketonuria are exceedingly rare. We report on a patient who had received a delayed diagnosis of phenylketonuria as an infant and subsequently developed levodopa‐responsive parkinsonism at the age of 33. Single‐photon emission computed tomography (SPECT) using 123I‐FP‐CIT ([123)I]‐2 beta‐carbomethoxy‐3beta‐(‐4‐iodophenyl)‐N‐(3‐fluoropropyl)‐nortropane) used to measure dopamine transporter levels on two occasions, 7 and 9 years after the onset of neurological symptoms, were normal. Iodine‐123‐iodo‐lisuride SPECT (IBZM) imaging, however, showed reduced caudate over putamen binding. This combination of imaging findings indicates a possible upregulation of postsynaptic D2 receptors in the context of intact presynaptic dopamine nerve terminal density. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20146
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002B57
- to stream Istex, to step Curation: 002B57
- to stream Istex, to step Checkpoint: 002644
- to stream PubMed, to step Corpus: 003293
- to stream PubMed, to step Curation: 003293
- to stream PubMed, to step Checkpoint: 003427
- to stream Ncbi, to step Merge: 000F95
- to stream Ncbi, to step Curation: 000F95
- to stream Ncbi, to step Checkpoint: 000F95
Links to Exploration step
ISTEX:BCAEED37BD2A001AD26C8D9FF9DB7B7D46A1EC42Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">L‐dopa–responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings</title><author><name sortKey="Evans, Andrew H" sort="Evans, Andrew H" uniqKey="Evans A" first="Andrew H." last="Evans">Andrew H. Evans</name></author><author><name sortKey="Costa, Durval C" sort="Costa, Durval C" uniqKey="Costa D" first="Durval C." last="Costa">Durval C. Costa</name></author><author><name sortKey="Gacinovic, Sveto" sort="Gacinovic, Sveto" uniqKey="Gacinovic S" first="Sveto" last="Gacinovic">Sveto Gacinovic</name></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name></author><author><name sortKey="Heales, Simon" sort="Heales, Simon" uniqKey="Heales S" first="Simon" last="Heales">Simon Heales</name></author><author><name sortKey="Lee, Phillip" sort="Lee, Phillip" uniqKey="Lee P" first="Phillip" last="Lee">Phillip Lee</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BCAEED37BD2A001AD26C8D9FF9DB7B7D46A1EC42</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1002/mds.20146</idno><idno type="url">https://api.istex.fr/document/BCAEED37BD2A001AD26C8D9FF9DB7B7D46A1EC42/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002B57</idno><idno type="wicri:Area/Istex/Curation">002B57</idno><idno type="wicri:Area/Istex/Checkpoint">002644</idno><idno type="wicri:doubleKey">0885-3185:2004:Evans A:l:dopa:responsive</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:15390012</idno><idno type="wicri:Area/PubMed/Corpus">003293</idno><idno type="wicri:Area/PubMed/Curation">003293</idno><idno type="wicri:Area/PubMed/Checkpoint">003427</idno><idno type="wicri:Area/Ncbi/Merge">000F95</idno><idno type="wicri:Area/Ncbi/Curation">000F95</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F95</idno><idno type="wicri:doubleKey">0885-3185:2004:Evans A:l:dopa:responsive</idno><idno type="wicri:Area/Main/Merge">005621</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">L‐dopa–responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings</title><author><name sortKey="Evans, Andrew H" sort="Evans, Andrew H" uniqKey="Evans A" first="Andrew H." last="Evans">Andrew H. Evans</name><affiliation><wicri:noCountry code="subField">University College London</wicri:noCountry></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Costa, Durval C" sort="Costa, Durval C" uniqKey="Costa D" first="Durval C." last="Costa">Durval C. Costa</name><affiliation><wicri:noCountry code="subField">Porto Portugal</wicri:noCountry></affiliation></author><author><name sortKey="Gacinovic, Sveto" sort="Gacinovic, Sveto" uniqKey="Gacinovic S" first="Sveto" last="Gacinovic">Sveto Gacinovic</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Institute of Nuclear Medicine, UCL Medical School, Middlesex Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name><affiliation><wicri:noCountry code="subField">University College London</wicri:noCountry></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Heales, Simon" sort="Heales, Simon" uniqKey="Heales S" first="Simon" last="Heales">Simon Heales</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurometabolic Unit, The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lee, Phillip" sort="Lee, Phillip" uniqKey="Lee P" first="Phillip" last="Lee">Phillip Lee</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Charles Dent Metabolic Unit, The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation><wicri:noCountry code="subField">University College London</wicri:noCountry><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-10">2004-10</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1232">1232</biblScope><biblScope unit="page" to="1236">1236</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BCAEED37BD2A001AD26C8D9FF9DB7B7D46A1EC42</idno><idno type="DOI">10.1002/mds.20146</idno><idno type="ArticleID">MDS20146</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antiparkinson Agents (therapeutic use)</term><term>Benzamides (diagnostic use)</term><term>Brain (blood supply)</term><term>Brain (radionuclide imaging)</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Humans</term><term>Iodine Radioisotopes (diagnostic use)</term><term>Levodopa (therapeutic use)</term><term>Membrane Glycoproteins (metabolism)</term><term>Membrane Transport Proteins (metabolism)</term><term>Nerve Tissue Proteins (metabolism)</term><term>PKU</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (metabolism)</term><term>Phenylketonurias (complications)</term><term>Pyrrolidines (diagnostic use)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Receptors, Dopamine D2 (metabolism)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tropanes (diagnostic use)</term><term>parkinsonism</term><term>single‐photon emission computed tomography</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Benzamides</term><term>Iodine Radioisotopes</term><term>Pyrrolidines</term><term>Radiopharmaceuticals</term><term>Tropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins</term><term>Nerve Tissue Proteins</term><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term><term>Phenylketonurias</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Humans</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reports of parkinsonism in phenylketonuria are exceedingly rare. We report on a patient who had received a delayed diagnosis of phenylketonuria as an infant and subsequently developed levodopa‐responsive parkinsonism at the age of 33. Single‐photon emission computed tomography (SPECT) using 123I‐FP‐CIT ([123)I]‐2 beta‐carbomethoxy‐3beta‐(‐4‐iodophenyl)‐N‐(3‐fluoropropyl)‐nortropane) used to measure dopamine transporter levels on two occasions, 7 and 9 years after the onset of neurological symptoms, were normal. Iodine‐123‐iodo‐lisuride SPECT (IBZM) imaging, however, showed reduced caudate over putamen binding. This combination of imaging findings indicates a possible upregulation of postsynaptic D2 receptors in the context of intact presynaptic dopamine nerve terminal density. © 2004 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.20146"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">L‐dopa–responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings</title><author><name sortKey="Evans, Andrew H" sort="Evans, Andrew H" uniqKey="Evans A" first="Andrew H." last="Evans">Andrew H. Evans</name></author><author><name sortKey="Costa, Durval C" sort="Costa, Durval C" uniqKey="Costa D" first="Durval C." last="Costa">Durval C. Costa</name></author><author><name sortKey="Gacinovic, Sveto" sort="Gacinovic, Sveto" uniqKey="Gacinovic S" first="Sveto" last="Gacinovic">Sveto Gacinovic</name></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name></author><author><name sortKey="Heales, Simon" sort="Heales, Simon" uniqKey="Heales S" first="Simon" last="Heales">Simon Heales</name></author><author><name sortKey="Lee, Phillip" sort="Lee, Phillip" uniqKey="Lee P" first="Phillip" last="Lee">Phillip Lee</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BCAEED37BD2A001AD26C8D9FF9DB7B7D46A1EC42</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1002/mds.20146</idno><idno type="url">https://api.istex.fr/document/BCAEED37BD2A001AD26C8D9FF9DB7B7D46A1EC42/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002B57</idno><idno type="wicri:Area/Istex/Curation">002B57</idno><idno type="wicri:Area/Istex/Checkpoint">002644</idno><idno type="wicri:doubleKey">0885-3185:2004:Evans A:l:dopa:responsive</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">L‐dopa–responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings</title><author><name sortKey="Evans, Andrew H" sort="Evans, Andrew H" uniqKey="Evans A" first="Andrew H." last="Evans">Andrew H. Evans</name><affiliation><wicri:noCountry code="subField">University College London</wicri:noCountry></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Costa, Durval C" sort="Costa, Durval C" uniqKey="Costa D" first="Durval C." last="Costa">Durval C. Costa</name><affiliation><wicri:noCountry code="subField">Porto Portugal</wicri:noCountry></affiliation></author><author><name sortKey="Gacinovic, Sveto" sort="Gacinovic, Sveto" uniqKey="Gacinovic S" first="Sveto" last="Gacinovic">Sveto Gacinovic</name><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Institute of Nuclear Medicine, UCL Medical School, Middlesex Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name><affiliation><wicri:noCountry code="subField">University College London</wicri:noCountry></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Royal Brisbane Hospital, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Heales, Simon" sort="Heales, Simon" uniqKey="Heales S" first="Simon" last="Heales">Simon Heales</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurometabolic Unit, The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lee, Phillip" sort="Lee, Phillip" uniqKey="Lee P" first="Phillip" last="Lee">Phillip Lee</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Charles Dent Metabolic Unit, The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation><wicri:noCountry code="subField">University College London</wicri:noCountry><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The National Hospital for Neurology and Neurosurgery, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-10">2004-10</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1232">1232</biblScope><biblScope unit="page" to="1236">1236</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">BCAEED37BD2A001AD26C8D9FF9DB7B7D46A1EC42</idno><idno type="DOI">10.1002/mds.20146</idno><idno type="ArticleID">MDS20146</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>PKU</term><term>parkinsonism</term><term>single‐photon emission computed tomography</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reports of parkinsonism in phenylketonuria are exceedingly rare. We report on a patient who had received a delayed diagnosis of phenylketonuria as an infant and subsequently developed levodopa‐responsive parkinsonism at the age of 33. Single‐photon emission computed tomography (SPECT) using 123I‐FP‐CIT ([123)I]‐2 beta‐carbomethoxy‐3beta‐(‐4‐iodophenyl)‐N‐(3‐fluoropropyl)‐nortropane) used to measure dopamine transporter levels on two occasions, 7 and 9 years after the onset of neurological symptoms, were normal. Iodine‐123‐iodo‐lisuride SPECT (IBZM) imaging, however, showed reduced caudate over putamen binding. This combination of imaging findings indicates a possible upregulation of postsynaptic D2 receptors in the context of intact presynaptic dopamine nerve terminal density. © 2004 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">L-Dopa-responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings.</title><author><name sortKey="Evans, Andrew H" sort="Evans, Andrew H" uniqKey="Evans A" first="Andrew H" last="Evans">Andrew H. Evans</name><affiliation wicri:level="1"><nlm:affiliation>Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, University College London</wicri:regionArea><wicri:noRegion>University College London</wicri:noRegion></affiliation></author><author><name sortKey="Costa, Durval C" sort="Costa, Durval C" uniqKey="Costa D" first="Durval C" last="Costa">Durval C. Costa</name></author><author><name sortKey="Gacinovic, Sveto" sort="Gacinovic, Sveto" uniqKey="Gacinovic S" first="Sveto" last="Gacinovic">Sveto Gacinovic</name></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D" last="O'Sullivan">John D. O'Sullivan</name></author><author><name sortKey="Heales, Simon" sort="Heales, Simon" uniqKey="Heales S" first="Simon" last="Heales">Simon Heales</name></author><author><name sortKey="Lee, Phillip" sort="Lee, Phillip" uniqKey="Lee P" first="Phillip" last="Lee">Phillip Lee</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15390012</idno><idno type="pmid">15390012</idno><idno type="doi">10.1002/mds.20146</idno><idno type="wicri:Area/PubMed/Corpus">003293</idno><idno type="wicri:Area/PubMed/Curation">003293</idno><idno type="wicri:Area/PubMed/Checkpoint">003427</idno><idno type="wicri:Area/Ncbi/Merge">000F95</idno><idno type="wicri:Area/Ncbi/Curation">000F95</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F95</idno><idno type="wicri:doubleKey">0885-3185:2004:Evans A:l:dopa:responsive</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">L-Dopa-responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings.</title><author><name sortKey="Evans, Andrew H" sort="Evans, Andrew H" uniqKey="Evans A" first="Andrew H" last="Evans">Andrew H. Evans</name><affiliation wicri:level="1"><nlm:affiliation>Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, University College London</wicri:regionArea><wicri:noRegion>University College London</wicri:noRegion></affiliation></author><author><name sortKey="Costa, Durval C" sort="Costa, Durval C" uniqKey="Costa D" first="Durval C" last="Costa">Durval C. Costa</name></author><author><name sortKey="Gacinovic, Sveto" sort="Gacinovic, Sveto" uniqKey="Gacinovic S" first="Sveto" last="Gacinovic">Sveto Gacinovic</name></author><author><name sortKey="Katzenschlager, Regina" sort="Katzenschlager, Regina" uniqKey="Katzenschlager R" first="Regina" last="Katzenschlager">Regina Katzenschlager</name></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D" last="O'Sullivan">John D. O'Sullivan</name></author><author><name sortKey="Heales, Simon" sort="Heales, Simon" uniqKey="Heales S" first="Simon" last="Heales">Simon Heales</name></author><author><name sortKey="Lee, Phillip" sort="Lee, Phillip" uniqKey="Lee P" first="Phillip" last="Lee">Phillip Lee</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antiparkinson Agents (therapeutic use)</term><term>Benzamides (diagnostic use)</term><term>Brain (blood supply)</term><term>Brain (radionuclide imaging)</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Humans</term><term>Iodine Radioisotopes (diagnostic use)</term><term>Levodopa (therapeutic use)</term><term>Membrane Glycoproteins (metabolism)</term><term>Membrane Transport Proteins (metabolism)</term><term>Nerve Tissue Proteins (metabolism)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (metabolism)</term><term>Phenylketonurias (complications)</term><term>Pyrrolidines (diagnostic use)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Receptors, Dopamine D2 (metabolism)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tropanes (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Benzamides</term><term>Iodine Radioisotopes</term><term>Pyrrolidines</term><term>Radiopharmaceuticals</term><term>Tropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins</term><term>Nerve Tissue Proteins</term><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term><term>Phenylketonurias</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Female</term><term>Humans</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reports of parkinsonism in phenylketonuria are exceedingly rare. We report on a patient who had received a delayed diagnosis of phenylketonuria as an infant and subsequently developed levodopa-responsive parkinsonism at the age of 33. Single-photon emission computed tomography (SPECT) using (123)I-FP-CIT ([(123))I]-2 beta-carbomethoxy-3beta-(-4-iodophenyl)-N-(3-fluoropropyl)-nortropane) used to measure dopamine transporter levels on two occasions, 7 and 9 years after the onset of neurological symptoms, were normal. Iodine-123-iodo-lisuride SPECT (IBZM) imaging, however, showed reduced caudate over putamen binding. This combination of imaging findings indicates a possible upregulation of postsynaptic D2 receptors in the context of intact presynaptic dopamine nerve terminal density.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005621 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 005621 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Merge
|type= RBID
|clé= ISTEX:BCAEED37BD2A001AD26C8D9FF9DB7B7D46A1EC42
|texte= L‐dopa–responsive Parkinson's syndrome in association with phenylketonuria: In vivo dopamine transporter and D2 receptor findings
}}
| This area was generated with Dilib version V0.6.23. |  |