MovDisordV3, Main, Merge, bibRecord, 005318

Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease

Identifieur interne : 005318 ( Main/Merge ); précédent : 005317; suivant : 005319

Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease

Auteurs : Manuela Contin [Italie] ; Paolo Martinelli [Italie] ; Mirella Mochi [Italie] ; Roberto Riva [Italie] ; Fiorenzo Albani [Italie] ; Agostino Baruzzi [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2005.

RBID : Pascal:05-0363485

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Polymorphisme, Catechol O-methyltransferase, Lévodopa, Pharmacocinétique, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Catechol O-methyltransferase, Human, Levodopa, Nervous system diseases, Parkinson disease, Pharmacokinetics, Polymorphism.

Abstract

We explored the potential effect of catechol-O-methyltransferase (COMT) genetic polymorphism on the pharmacokinetics and pharmacodynamics of a standard oral dose of levodopa in patients with Parkinson's disease (PD). We prospectively collected blood samples for COMT genotyping from a population of 104 PD patients. Each patient was examined by a standard oral levodopa/benserazide test, based on simultaneous serial measurements of plasma levodopa concentrations, finger-tapping motor effects and dyskinesia ratings, up to 4 hours after dosing. The main levodopa pharmacokinetic outcome variables were time to peak and peak plasma concentration, plasma elimination half-life, and the area under the plasma concentration-time curve. The main outcome levodopa pharmacodynamic variables were latency, duration, and magnitude of the motor effect elicited by the levodopa test dose, the area under the tapping effect-time curve, and the presence of dyskinesias. Nineteen patients (18%) harbored the low-activity homozygous COMT genotype (A/A), 63 patients (61%) carried the intermediate-activity heterozygous COMT genotype (A/G) and 22 patients (21%) had the high-activity homozygous COMT genotype (G/G). The three groups were comparable for vital and clinical characteristics. No significant difference was found in levodopa main pharmacokinetic-pharmacodynamic variables and dyskinesia incidence among the three subgroups of patients. We failed to identify clinically relevant levodopa pharmacokinetic-pharmacodynamic response patterns associated with the COMT polymorphism in PD patients.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001E53
to stream PascalFrancis, to step Curation: 000E68
to stream PascalFrancis, to step Checkpoint: 001E40

Links to Exploration step

Pascal:05-0363485

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease</title>
<author><name sortKey="Contin, Manuela" sort="Contin, Manuela" uniqKey="Contin M" first="Manuela" last="Contin">Manuela Contin</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martinelli, Paolo" sort="Martinelli, Paolo" uniqKey="Martinelli P" first="Paolo" last="Martinelli">Paolo Martinelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mochi, Mirella" sort="Mochi, Mirella" uniqKey="Mochi M" first="Mirella" last="Mochi">Mirella Mochi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Riva, Roberto" sort="Riva, Roberto" uniqKey="Riva R" first="Roberto" last="Riva">Roberto Riva</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Albani, Fiorenzo" sort="Albani, Fiorenzo" uniqKey="Albani F" first="Fiorenzo" last="Albani">Fiorenzo Albani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0363485</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 05-0363485 INIST</idno>
<idno type="RBID">Pascal:05-0363485</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001E53</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000E68</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001E40</idno>
<idno type="wicri:doubleKey">0885-3185:2005:Contin M:genetic:polymorphism:of</idno>
<idno type="wicri:Area/Main/Merge">005318</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease</title>
<author><name sortKey="Contin, Manuela" sort="Contin, Manuela" uniqKey="Contin M" first="Manuela" last="Contin">Manuela Contin</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martinelli, Paolo" sort="Martinelli, Paolo" uniqKey="Martinelli P" first="Paolo" last="Martinelli">Paolo Martinelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mochi, Mirella" sort="Mochi, Mirella" uniqKey="Mochi M" first="Mirella" last="Mochi">Mirella Mochi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Riva, Roberto" sort="Riva, Roberto" uniqKey="Riva R" first="Roberto" last="Riva">Roberto Riva</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Albani, Fiorenzo" sort="Albani, Fiorenzo" uniqKey="Albani F" first="Fiorenzo" last="Albani">Fiorenzo Albani</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurology Clinic, Department of Neurological Sciences, University of Bologna</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Catechol O-methyltransferase</term>
<term>Human</term>
<term>Levodopa</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Pharmacokinetics</term>
<term>Polymorphism</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
<term>Polymorphisme</term>
<term>Catechol O-methyltransferase</term>
<term>Lévodopa</term>
<term>Pharmacocinétique</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We explored the potential effect of catechol-O-methyltransferase (COMT) genetic polymorphism on the pharmacokinetics and pharmacodynamics of a standard oral dose of levodopa in patients with Parkinson's disease (PD). We prospectively collected blood samples for COMT genotyping from a population of 104 PD patients. Each patient was examined by a standard oral levodopa/benserazide test, based on simultaneous serial measurements of plasma levodopa concentrations, finger-tapping motor effects and dyskinesia ratings, up to 4 hours after dosing. The main levodopa pharmacokinetic outcome variables were time to peak and peak plasma concentration, plasma elimination half-life, and the area under the plasma concentration-time curve. The main outcome levodopa pharmacodynamic variables were latency, duration, and magnitude of the motor effect elicited by the levodopa test dose, the area under the tapping effect-time curve, and the presence of dyskinesias. Nineteen patients (18%) harbored the low-activity homozygous COMT genotype (A/A), 63 patients (61%) carried the intermediate-activity heterozygous COMT genotype (A/G) and 22 patients (21%) had the high-activity homozygous COMT genotype (G/G). The three groups were comparable for vital and clinical characteristics. No significant difference was found in levodopa main pharmacokinetic-pharmacodynamic variables and dyskinesia incidence among the three subgroups of patients. We failed to identify clinically relevant levodopa pharmacokinetic-pharmacodynamic response patterns associated with the COMT polymorphism in PD patients.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Contin, Manuela" sort="Contin, Manuela" uniqKey="Contin M" first="Manuela" last="Contin">Manuela Contin</name>
</noRegion>
<name sortKey="Albani, Fiorenzo" sort="Albani, Fiorenzo" uniqKey="Albani F" first="Fiorenzo" last="Albani">Fiorenzo Albani</name>
<name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name>
<name sortKey="Martinelli, Paolo" sort="Martinelli, Paolo" uniqKey="Martinelli P" first="Paolo" last="Martinelli">Paolo Martinelli</name>
<name sortKey="Mochi, Mirella" sort="Mochi, Mirella" uniqKey="Mochi M" first="Mirella" last="Mochi">Mirella Mochi</name>
<name sortKey="Riva, Roberto" sort="Riva, Roberto" uniqKey="Riva R" first="Roberto" last="Riva">Roberto Riva</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005318 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 005318 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     Pascal:05-0363485
   |texte=   Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease

Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri