MovDisordV3, Main, Merge, bibRecord, 005195

Sleep apnea syndrome in Parkinson's disease. A case-control study in 49 patients

Identifieur interne : 005195 ( Main/Merge ); précédent : 005194; suivant : 005196

Sleep apnea syndrome in Parkinson's disease. A case-control study in 49 patients

Auteurs : Nico J. Diederich [Luxembourg (pays)] ; Michel Vaillant [Luxembourg (pays)] ; Mike Leischen [Luxembourg (pays)] ; Giovanna Mancuso [Luxembourg (pays)] ; Serge Golinval [Luxembourg (pays)] ; Romain Nati [Luxembourg (pays)] ; Marc Schlesser [Luxembourg (pays)]

Source :

Movement disorders [ 0885-3185 ] ; 2005.

RBID : Pascal:06-0077731

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Apnée sommeil syndrome, Parkinson maladie, Etude cas témoin, Homme, Polysomnographie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Case control study, Human, Nervous system diseases, Parkinson disease, Polysomnography, Sleep apnea syndrome.

Abstract

In PD, the impact of nocturnal respiration on sleep continuity and architecture has not been systematically investigated by polysomnography (PSG). We performed a case-control study with retrospective analysis of PSG data of 49 PD patients. After classifying the PD patients according to their apnea/hypopnea index (AHI), they were matched with 49 controls in terms of age, gender, and AHI. There were 21 PD patients (43%) who had sleep apnea syndrome (SAS), classified as mild (AHI, 5-15) in 10 patients, moderate (AHI, > 15-30) in 4 patients, and severe (AHI, > 30) in 7 patients. PD patients had more deep sleep (P = 0.02) and more nocturnal awakenings (P < 0.001) than the controls. Their body mass index (BMI) was lower (P = 0.04), and they maintained a more favorable respiratory profile, with higher mean and minimal oxygen saturation values (P = 0.006 and 0.01, respectively). These differences were preserved when only considering PD patients with AHI > 15. PD patients had less obstructive sleep apneas (P = 0.035), independently from the factor AHI. Only the respiratory changes of 4 PD patients with BMI > 27 and AHI > 15 (8%) approximated those seen in the controls. At an early or middle stage of the disease, non-obese PD patients frequently have AHI values suggesting SAS, however, without the oxygen desaturation profile of SAS. Longitudinal studies of patients with such "abortive" SAS are warranted to establish if this finding reflects benign nocturnal respiratory muscle dyskinesia or constitutes a precursor sign of dysautonomia in PD.

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Pascal:06-0077731

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Sleep apnea syndrome in Parkinson's disease. A case-control study in 49 patients</title>
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<author><name sortKey="Vaillant, Michel" sort="Vaillant, Michel" uniqKey="Vaillant M" first="Michel" last="Vaillant">Michel Vaillant</name>
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<author><name sortKey="Mancuso, Giovanna" sort="Mancuso, Giovanna" uniqKey="Mancuso G" first="Giovanna" last="Mancuso">Giovanna Mancuso</name>
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<author><name sortKey="Golinval, Serge" sort="Golinval, Serge" uniqKey="Golinval S" first="Serge" last="Golinval">Serge Golinval</name>
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<country>Luxembourg (pays)</country>
<wicri:noRegion>Department of Internal Medicine, Centre Hospitalier de Luxembourg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nati, Romain" sort="Nati, Romain" uniqKey="Nati R" first="Romain" last="Nati">Romain Nati</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Interdisciplinary Sleep Laboratory, Centre Hospitalier de Luxembourg</s1>
<s3>LUX</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Luxembourg (pays)</country>
<wicri:noRegion>Interdisciplinary Sleep Laboratory, Centre Hospitalier de Luxembourg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Internal Medicine, Centre Hospitalier de Luxembourg</s1>
<s3>LUX</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Luxembourg (pays)</country>
<wicri:noRegion>Department of Internal Medicine, Centre Hospitalier de Luxembourg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schlesser, Marc" sort="Schlesser, Marc" uniqKey="Schlesser M" first="Marc" last="Schlesser">Marc Schlesser</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Interdisciplinary Sleep Laboratory, Centre Hospitalier de Luxembourg</s1>
<s3>LUX</s3>
<sZ>1 aut.</sZ>
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<country>Luxembourg (pays)</country>
<wicri:noRegion>Interdisciplinary Sleep Laboratory, Centre Hospitalier de Luxembourg</wicri:noRegion>
</affiliation>
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<country>Luxembourg (pays)</country>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case control study</term>
<term>Human</term>
<term>Nervous system diseases</term>
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<term>Sleep apnea syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Apnée sommeil syndrome</term>
<term>Parkinson maladie</term>
<term>Etude cas témoin</term>
<term>Homme</term>
<term>Polysomnographie</term>
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<front><div type="abstract" xml:lang="en">In PD, the impact of nocturnal respiration on sleep continuity and architecture has not been systematically investigated by polysomnography (PSG). We performed a case-control study with retrospective analysis of PSG data of 49 PD patients. After classifying the PD patients according to their apnea/hypopnea index (AHI), they were matched with 49 controls in terms of age, gender, and AHI. There were 21 PD patients (43%) who had sleep apnea syndrome (SAS), classified as mild (AHI, 5-15) in 10 patients, moderate (AHI, > 15-30) in 4 patients, and severe (AHI, > 30) in 7 patients. PD patients had more deep sleep (P = 0.02) and more nocturnal awakenings (P < 0.001) than the controls. Their body mass index (BMI) was lower (P = 0.04), and they maintained a more favorable respiratory profile, with higher mean and minimal oxygen saturation values (P = 0.006 and 0.01, respectively). These differences were preserved when only considering PD patients with AHI > 15. PD patients had less obstructive sleep apneas (P = 0.035), independently from the factor AHI. Only the respiratory changes of 4 PD patients with BMI > 27 and AHI > 15 (8%) approximated those seen in the controls. At an early or middle stage of the disease, non-obese PD patients frequently have AHI values suggesting SAS, however, without the oxygen desaturation profile of SAS. Longitudinal studies of patients with such "abortive" SAS are warranted to establish if this finding reflects benign nocturnal respiratory muscle dyskinesia or constitutes a precursor sign of dysautonomia in PD.</div>
</front>
</TEI>
<affiliations><list><country><li>Luxembourg (pays)</li>
</country>
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<tree><country name="Luxembourg (pays)"><noRegion><name sortKey="Diederich, Nico J" sort="Diederich, Nico J" uniqKey="Diederich N" first="Nico J." last="Diederich">Nico J. Diederich</name>
</noRegion>
<name sortKey="Diederich, Nico J" sort="Diederich, Nico J" uniqKey="Diederich N" first="Nico J." last="Diederich">Nico J. Diederich</name>
<name sortKey="Golinval, Serge" sort="Golinval, Serge" uniqKey="Golinval S" first="Serge" last="Golinval">Serge Golinval</name>
<name sortKey="Leischen, Mike" sort="Leischen, Mike" uniqKey="Leischen M" first="Mike" last="Leischen">Mike Leischen</name>
<name sortKey="Mancuso, Giovanna" sort="Mancuso, Giovanna" uniqKey="Mancuso G" first="Giovanna" last="Mancuso">Giovanna Mancuso</name>
<name sortKey="Nati, Romain" sort="Nati, Romain" uniqKey="Nati R" first="Romain" last="Nati">Romain Nati</name>
<name sortKey="Nati, Romain" sort="Nati, Romain" uniqKey="Nati R" first="Romain" last="Nati">Romain Nati</name>
<name sortKey="Schlesser, Marc" sort="Schlesser, Marc" uniqKey="Schlesser M" first="Marc" last="Schlesser">Marc Schlesser</name>
<name sortKey="Schlesser, Marc" sort="Schlesser, Marc" uniqKey="Schlesser M" first="Marc" last="Schlesser">Marc Schlesser</name>
<name sortKey="Vaillant, Michel" sort="Vaillant, Michel" uniqKey="Vaillant M" first="Michel" last="Vaillant">Michel Vaillant</name>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Sleep apnea syndrome in Parkinson's disease. A case-control study in 49 patients

Sleep apnea syndrome in Parkinson's disease. A case-control study in 49 patients

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri