Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech
Identifieur interne : 005074 ( Main/Merge ); précédent : 005073; suivant : 005075Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech
Auteurs : Serge Pinto [France, Royaume-Uni] ; Michèle Gentil [France] ; Paul Krack [France] ; Paul Sauleau [France] ; Valérie Fraix [France] ; Alim-Louis Benabid [France] ; Pierre Pollak [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-11.
English descriptors
- KwdEn :
- Adult, Dysarthria (etiology), Dyskinesias (etiology), Electric Stimulation Therapy (adverse effects), Functional Laterality, Humans, Levodopa (adverse effects), L‐dopa, Middle Aged, Parkinson's disease, Parkinsonian Disorders (physiopathology), Parkinsonian Disorders (therapy), Severity of Illness Index, Subthalamic Nucleus (physiopathology), Subthalamic Nucleus (radiation effects), dysarthria, speech, subthalamic nucleus stimulation.
- MESH :
- chemical , adverse effects : Levodopa.
- adverse effects : Electric Stimulation Therapy.
- etiology : Dysarthria, Dyskinesias.
- physiopathology : Parkinsonian Disorders, Subthalamic Nucleus.
- radiation effects : Subthalamic Nucleus.
- therapy : Parkinsonian Disorders.
- mix :
Abstract
Levodopa (L‐dopa) and subthalamic nucleus (STN) stimulation treatments have been associated with both improvement and exacerbation of dysarthria in Parkinson's disease (PD). We report four cases illustrating variant responses of dysarthria to dopaminergic and STN stimulation therapies. Patients' motor disability and dysarthria were perceptually rated by the Unified Parkinson's Disease Rating Scale (UPDRS) in four conditions according to medication and STN stimulation. Dedicated software packages allowed acquisition and analysis of acoustic recordings. Case 1, who had a severe off period aphonia, experienced improvement of speech induced by both levodopa and STN stimulation. In Case 2, both treatments worsened speech due to the appearance of dyskinesias. Case 3 had a dysarthria exacerbation induced by STN stimulation with parameters above optimal levels, interpreted as current diffusion from the STN to corticobulbar fibers. In Case 4, dysarthria exacerbation occurred with stimulation at an electrode contact located caudally to the target, also arguing for current diffusion as a potential mechanism of speech worsening. The presented cases demonstrated variant effects in relation to L‐dopa and STN stimulation on speech. It seems that motor speech subcomponents can be improved like other limb motor aspect, but that complex coordination of all speech anatomical substrates is not responsive to STN stimulation. These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton–motor subsystems. © 2005 Movement Disorder Society
Url:
- https://api.istex.fr/document/077060E6701AD06B35201829319A89FB791126D1/fulltext/pdf
- https://hal.archives-ouvertes.fr/hal-00265250
- http://www.hal.inserm.fr/inserm-00391641
DOI: 10.1002/mds.20601
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ISTEX:077060E6701AD06B35201829319A89FB791126D1Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-11">2005-11</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1507">1507</biblScope><biblScope unit="page" to="1515">1515</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">077060E6701AD06B35201829319A89FB791126D1</idno><idno type="DOI">10.1002/mds.20601</idno><idno type="ArticleID">MDS20601</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Dysarthria (etiology)</term><term>Dyskinesias (etiology)</term><term>Electric Stimulation Therapy (adverse effects)</term><term>Functional Laterality</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>L‐dopa</term><term>Middle Aged</term><term>Parkinson's disease</term><term>Parkinsonian Disorders (physiopathology)</term><term>Parkinsonian Disorders (therapy)</term><term>Severity of Illness Index</term><term>Subthalamic Nucleus (physiopathology)</term><term>Subthalamic Nucleus (radiation effects)</term><term>dysarthria</term><term>speech</term><term>subthalamic nucleus stimulation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dysarthria</term><term>Dyskinesias</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinsonian Disorders</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="mix" xml:lang="en"><term>Adult</term><term>Functional Laterality</term><term>Humans</term><term>L-dopa</term><term>Middle Aged</term><term>Parkinson's disease</term><term>Severity of Illness Index</term><term>dysarthria</term><term>speech</term><term>subthalamic nucleus stimulation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa (L‐dopa) and subthalamic nucleus (STN) stimulation treatments have been associated with both improvement and exacerbation of dysarthria in Parkinson's disease (PD). We report four cases illustrating variant responses of dysarthria to dopaminergic and STN stimulation therapies. Patients' motor disability and dysarthria were perceptually rated by the Unified Parkinson's Disease Rating Scale (UPDRS) in four conditions according to medication and STN stimulation. Dedicated software packages allowed acquisition and analysis of acoustic recordings. Case 1, who had a severe off period aphonia, experienced improvement of speech induced by both levodopa and STN stimulation. In Case 2, both treatments worsened speech due to the appearance of dyskinesias. Case 3 had a dysarthria exacerbation induced by STN stimulation with parameters above optimal levels, interpreted as current diffusion from the STN to corticobulbar fibers. In Case 4, dysarthria exacerbation occurred with stimulation at an electrode contact located caudally to the target, also arguing for current diffusion as a potential mechanism of speech worsening. The presented cases demonstrated variant effects in relation to L‐dopa and STN stimulation on speech. It seems that motor speech subcomponents can be improved like other limb motor aspect, but that complex coordination of all speech anatomical substrates is not responsive to STN stimulation. These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton–motor subsystems. © 2005 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.20601"><HAL><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changes induced by levodopa and subthalamic nucleus stimulation on Parkinsonian speech</title><author><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2812" status="OLD"><orgName>Neurosciences précliniques</orgName><desc><address><addrLine>CHU Grenoble 38043 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.lyon.inserm.fr/318/index.html</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation name="U318" active="#struct-300002" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="VALID"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><desc><address><addrLine>BP 53 - 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Pollak</name></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-00265250</idno><idno type="halId">hal-00265250</idno><idno type="halUri">https://hal.archives-ouvertes.fr/hal-00265250</idno><idno type="url">https://hal.archives-ouvertes.fr/hal-00265250</idno><idno type="doi">10.1002/mds.20601</idno><date when="2005">2005</date><idno type="wicri:Area/Hal/Corpus">000009</idno><idno type="wicri:Area/Hal/Curation">000009</idno><idno type="wicri:Area/Hal/Checkpoint">000067</idno><idno type="wicri:doubleKey">0885-3185:2005:Pinto S:changes:induced:by</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Changes induced by levodopa and subthalamic nucleus stimulation on Parkinsonian speech</title><author><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2812" status="OLD"><orgName>Neurosciences précliniques</orgName><desc><address><addrLine>CHU Grenoble 38043 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.lyon.inserm.fr/318/index.html</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation name="U318" active="#struct-300002" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="VALID"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><desc><address><addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle><tutelle name="U318" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Gentil, Michele" sort="Gentil, Michele" uniqKey="Gentil M" first="Michèle" last="Gentil">Michèle Gentil</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2812" status="OLD"><orgName>Neurosciences précliniques</orgName><desc><address><addrLine>CHU Grenoble 38043 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.lyon.inserm.fr/318/index.html</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation name="U318" active="#struct-300002" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="VALID"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><desc><address><addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle><tutelle name="U318" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2812" status="OLD"><orgName>Neurosciences précliniques</orgName><desc><address><addrLine>CHU Grenoble 38043 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.lyon.inserm.fr/318/index.html</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation name="U318" active="#struct-300002" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="VALID"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><desc><address><addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle><tutelle name="U318" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2812" status="OLD"><orgName>Neurosciences précliniques</orgName><desc><address><addrLine>CHU Grenoble 38043 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.lyon.inserm.fr/318/index.html</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation name="U318" active="#struct-300002" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="VALID"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><desc><address><addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle><tutelle name="U318" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2812" status="OLD"><orgName>Neurosciences précliniques</orgName><desc><address><addrLine>CHU Grenoble 38043 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.lyon.inserm.fr/318/index.html</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation name="U318" active="#struct-300002" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="VALID"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><desc><address><addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle><tutelle name="U318" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2812" status="OLD"><orgName>Neurosciences précliniques</orgName><desc><address><addrLine>CHU Grenoble 38043 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.lyon.inserm.fr/318/index.html</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation name="U318" active="#struct-300002" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="VALID"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><desc><address><addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle><tutelle name="U318" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name></author></analytic><idno type="DOI">10.1002/mds.20601</idno><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><imprint><date type="datePub">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>L-dopa</term><term>Parkinson's disease</term><term>dysarthria</term><term>speech</term><term>subthalamic nucleus stimulation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa (L-dopa) and subthalamic nucleus (STN) stimulation treatments have been associated with both improvement and exacerbation of dysarthria in Parkinson's disease (PD). We report four cases illustrating variant responses of dysarthria to dopaminergic and STN stimulation therapies. Patients' motor disability and dysarthria were perceptually rated by the Unified Parkinson's Disease Rating Scale (UPDRS) in four conditions according to medication and STN stimulation. Dedicated software packages allowed acquisition and analysis of acoustic recordings. Case 1, who had a severe off period aphonia, experienced improvement of speech induced by both levodopa and STN stimulation. In Case 2, both treatments worsened speech due to the appearance of dyskinesias. Case 3 had a dysarthria exacerbation induced by STN stimulation with parameters above optimal levels, interpreted as current diffusion from the STN to corticobulbar fibers. In Case 4, dysarthria exacerbation occurred with stimulation at an electrode contact located caudally to the target, also arguing for current diffusion as a potential mechanism of speech worsening. The presented cases demonstrated variant effects in relation to L-dopa and STN stimulation on speech. It seems that motor speech subcomponents can be improved like other limb motor aspect, but that complex coordination of all speech anatomical substrates is not responsive to STN stimulation. These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton-motor subsystems.</div></front></TEI></HAL><HAL><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech.</title><author><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2812" status="OLD"><orgName>Neurosciences précliniques</orgName><desc><address><addrLine>CHU Grenoble 38043 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.lyon.inserm.fr/318/index.html</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation name="U318" active="#struct-300002" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="VALID"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><desc><address><addrLine>BP 53 - 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38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle><tutelle name="U318" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2812" status="OLD"><orgName>Neurosciences précliniques</orgName><desc><address><addrLine>CHU Grenoble 38043 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.lyon.inserm.fr/318/index.html</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation name="U318" active="#struct-300002" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="VALID"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><desc><address><addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle><tutelle name="U318" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2812" status="OLD"><orgName>Neurosciences précliniques</orgName><desc><address><addrLine>CHU Grenoble 38043 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.lyon.inserm.fr/318/index.html</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation name="U318" active="#struct-300002" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="VALID"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><desc><address><addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle><tutelle name="U318" active="#struct-300002" type="direct"><org type="institution" xml:id="struct-300002" status="VALID"><orgName>INSERM</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author></analytic><idno type="DOI">10.1002/mds.20601</idno><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><imprint><date type="datePub">2005-11</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa (L-dopa) and subthalamic nucleus (STN) stimulation treatments have been associated with both improvement and exacerbation of dysarthria in Parkinson's disease (PD). We report four cases illustrating variant responses of dysarthria to dopaminergic and STN stimulation therapies. Patients' motor disability and dysarthria were perceptually rated by the Unified Parkinson's Disease Rating Scale (UPDRS) in four conditions according to medication and STN stimulation. Dedicated software packages allowed acquisition and analysis of acoustic recordings. Case 1, who had a severe off period aphonia, experienced improvement of speech induced by both levodopa and STN stimulation. In Case 2, both treatments worsened speech due to the appearance of dyskinesias. Case 3 had a dysarthria exacerbation induced by STN stimulation with parameters above optimal levels, interpreted as current diffusion from the STN to corticobulbar fibers. In Case 4, dysarthria exacerbation occurred with stimulation at an electrode contact located caudally to the target, also arguing for current diffusion as a potential mechanism of speech worsening. The presented cases demonstrated variant effects in relation to L-dopa and STN stimulation on speech. It seems that motor speech subcomponents can be improved like other limb motor aspect, but that complex coordination of all speech anatomical substrates is not responsive to STN stimulation. These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton-motor subsystems.</div></front></TEI></HAL><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech</title><author><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name></author><author><name sortKey="Gentil, Michele" sort="Gentil, Michele" uniqKey="Gentil M" first="Michèle" last="Gentil">Michèle Gentil</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:077060E6701AD06B35201829319A89FB791126D1</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/mds.20601</idno><idno type="url">https://api.istex.fr/document/077060E6701AD06B35201829319A89FB791126D1/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000325</idno><idno type="wicri:Area/Istex/Curation">000325</idno><idno type="wicri:Area/Istex/Checkpoint">002397</idno><idno type="wicri:doubleKey">0885-3185:2005:Pinto S:changes:induced:by</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech</title><author><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Précliniques, INSERM Unité 318, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Current Address: Institute of Neurology, Sobell Department of Motor Neuroscience and Movement Disorders, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gentil, Michele" sort="Gentil, Michele" uniqKey="Gentil M" first="Michèle" last="Gentil">Michèle Gentil</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Précliniques, INSERM Unité 318, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Précliniques, INSERM Unité 318, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Département de Neurologie, Grenoble University Hospital, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Précliniques, INSERM Unité 318, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Service des Explorations Fonctionnelles Neurologiques, Rennes University Hospital, Rennes</wicri:regionArea><placeName><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Précliniques, INSERM Unité 318, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Département de Neurologie, Grenoble University Hospital, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Précliniques, INSERM Unité 318, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Département de Neurochirurgie, Grenoble University Hospital, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Précliniques, INSERM Unité 318, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Département de Neurologie, Grenoble University Hospital, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-11">2005-11</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1507">1507</biblScope><biblScope unit="page" to="1515">1515</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">077060E6701AD06B35201829319A89FB791126D1</idno><idno type="DOI">10.1002/mds.20601</idno><idno type="ArticleID">MDS20601</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>L‐dopa</term><term>Parkinson's disease</term><term>dysarthria</term><term>speech</term><term>subthalamic nucleus stimulation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa (L‐dopa) and subthalamic nucleus (STN) stimulation treatments have been associated with both improvement and exacerbation of dysarthria in Parkinson's disease (PD). We report four cases illustrating variant responses of dysarthria to dopaminergic and STN stimulation therapies. Patients' motor disability and dysarthria were perceptually rated by the Unified Parkinson's Disease Rating Scale (UPDRS) in four conditions according to medication and STN stimulation. Dedicated software packages allowed acquisition and analysis of acoustic recordings. Case 1, who had a severe off period aphonia, experienced improvement of speech induced by both levodopa and STN stimulation. In Case 2, both treatments worsened speech due to the appearance of dyskinesias. Case 3 had a dysarthria exacerbation induced by STN stimulation with parameters above optimal levels, interpreted as current diffusion from the STN to corticobulbar fibers. In Case 4, dysarthria exacerbation occurred with stimulation at an electrode contact located caudally to the target, also arguing for current diffusion as a potential mechanism of speech worsening. The presented cases demonstrated variant effects in relation to L‐dopa and STN stimulation on speech. It seems that motor speech subcomponents can be improved like other limb motor aspect, but that complex coordination of all speech anatomical substrates is not responsive to STN stimulation. These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton–motor subsystems. © 2005 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech.</title><author><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name><affiliation wicri:level="1"><nlm:affiliation>Neurosciences Précliniques, INSERM Unité 318, Grenoble, France. s.pinto@ion.ucl.ac.uk</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Précliniques, INSERM Unité 318, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Gentil, Michele" sort="Gentil, Michele" uniqKey="Gentil M" first="Michèle" last="Gentil">Michèle Gentil</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20601</idno><idno type="RBID">pubmed:16037917</idno><idno type="pmid">16037917</idno><idno type="wicri:Area/PubMed/Corpus">002F69</idno><idno type="wicri:Area/PubMed/Curation">002F69</idno><idno type="wicri:Area/PubMed/Checkpoint">003200</idno><idno type="wicri:Area/Ncbi/Merge">001343</idno><idno type="wicri:Area/Ncbi/Curation">001343</idno><idno type="wicri:Area/Ncbi/Checkpoint">001343</idno><idno type="wicri:doubleKey">0885-3185:2005:Pinto S:changes:induced:by</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech.</title><author><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name><affiliation wicri:level="1"><nlm:affiliation>Neurosciences Précliniques, INSERM Unité 318, Grenoble, France. s.pinto@ion.ucl.ac.uk</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Précliniques, INSERM Unité 318, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Gentil, Michele" sort="Gentil, Michele" uniqKey="Gentil M" first="Michèle" last="Gentil">Michèle Gentil</name></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name></author><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Dysarthria (etiology)</term><term>Dyskinesias (etiology)</term><term>Electric Stimulation Therapy (adverse effects)</term><term>Functional Laterality</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Middle Aged</term><term>Parkinsonian Disorders (physiopathology)</term><term>Parkinsonian Disorders (therapy)</term><term>Severity of Illness Index</term><term>Subthalamic Nucleus (physiopathology)</term><term>Subthalamic Nucleus (radiation effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dysarthria</term><term>Dyskinesias</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinsonian Disorders</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Functional Laterality</term><term>Humans</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Levodopa (L-dopa) and subthalamic nucleus (STN) stimulation treatments have been associated with both improvement and exacerbation of dysarthria in Parkinson's disease (PD). We report four cases illustrating variant responses of dysarthria to dopaminergic and STN stimulation therapies. Patients' motor disability and dysarthria were perceptually rated by the Unified Parkinson's Disease Rating Scale (UPDRS) in four conditions according to medication and STN stimulation. Dedicated software packages allowed acquisition and analysis of acoustic recordings. Case 1, who had a severe off period aphonia, experienced improvement of speech induced by both levodopa and STN stimulation. In Case 2, both treatments worsened speech due to the appearance of dyskinesias. Case 3 had a dysarthria exacerbation induced by STN stimulation with parameters above optimal levels, interpreted as current diffusion from the STN to corticobulbar fibers. In Case 4, dysarthria exacerbation occurred with stimulation at an electrode contact located caudally to the target, also arguing for current diffusion as a potential mechanism of speech worsening. The presented cases demonstrated variant effects in relation to L-dopa and STN stimulation on speech. It seems that motor speech subcomponents can be improved like other limb motor aspect, but that complex coordination of all speech anatomical substrates is not responsive to STN stimulation. These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton-motor subsystems.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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