Taiwanese cases of SCA2 are derived from a single founder
Identifieur interne : 004D96 ( Main/Merge ); précédent : 004D95; suivant : 004D97Taiwanese cases of SCA2 are derived from a single founder
Auteurs : Parastoo Momeni [États-Unis] ; Chin-Song Lu [Taïwan] ; Yah-Huei Wu Chou [Taïwan] ; Hsiu-Chen Chang [Taïwan] ; Rou-Shayn Chen [Taïwan] ; Chiung-Chu Chen [Taïwan] ; Jin-Tian Hsu [Taïwan] ; Andrew Singleton [États-Unis] ; John Hardy [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-12.
Descripteurs français
- Wicri :
- geographic : Taïwan.
English descriptors
- KwdEn :
- Adult, Aged, Ataxia (genetics), DNA Mutational Analysis, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Humans, Male, Middle Aged, Nerve Tissue Proteins (genetics), Parkinson Disease (genetics), Polymorphism, Single Nucleotide (genetics), SCA2, Taiwan (ethnology), ataxic phenotype, common founder, haplotype, parkinsonism.
- MESH :
- chemical , genetics : Nerve Tissue Proteins.
- geographic , ethnology : Taiwan.
- genetics : Ataxia, Parkinson Disease, Polymorphism, Single Nucleotide.
- Adult, Aged, DNA Mutational Analysis, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Humans, Male, Middle Aged.
Abstract
We have assessed the haplotypes at the ATXN2 locus in Taiwanese controls and in individuals with SCA2 ataxia with both ataxic and parkinsonian features. Our intention was to determine whether a different ataxin 2 haplotypes predisposed to the two phenotypes. In fact, our analysis showed that all SCA2 mutations carriers had the same ataxin 2 haplotype: haplotype B, which accounts for only 15% of control haplotypes, implying that there is a common founder for all Taiwanese SCA2 patients. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20638
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 003566
- to stream Istex, to step Curation: 003566
- to stream Istex, to step Checkpoint: 002119
- to stream PubMed, to step Corpus: 002F57
- to stream PubMed, to step Curation: 002F57
- to stream PubMed, to step Checkpoint: 002F45
- to stream Ncbi, to step Merge: 001355
- to stream Ncbi, to step Curation: 001355
- to stream Ncbi, to step Checkpoint: 001355
Links to Exploration step
ISTEX:3407D290292E763B9E8E498F1E075FA91318001ALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Taiwanese cases of SCA2 are derived from a single founder</title><author><name sortKey="Momeni, Parastoo" sort="Momeni, Parastoo" uniqKey="Momeni P" first="Parastoo" last="Momeni">Parastoo Momeni</name></author><author><name sortKey="Lu, Chin Ong" sort="Lu, Chin Ong" uniqKey="Lu C" first="Chin-Song" last="Lu">Chin-Song Lu</name></author><author><name sortKey="Chou, Yah Uei Wu" sort="Chou, Yah Uei Wu" uniqKey="Chou Y" first="Yah-Huei Wu" last="Chou">Yah-Huei Wu Chou</name></author><author><name sortKey="Chang, Hsiu Hen" sort="Chang, Hsiu Hen" uniqKey="Chang H" first="Hsiu-Chen" last="Chang">Hsiu-Chen Chang</name></author><author><name sortKey="Chen, Rou Hayn" sort="Chen, Rou Hayn" uniqKey="Chen R" first="Rou-Shayn" last="Chen">Rou-Shayn Chen</name></author><author><name sortKey="Chen, Chiung Hu" sort="Chen, Chiung Hu" uniqKey="Chen C" first="Chiung-Chu" last="Chen">Chiung-Chu Chen</name></author><author><name sortKey="Hsu, Jin Ian" sort="Hsu, Jin Ian" uniqKey="Hsu J" first="Jin-Tian" last="Hsu">Jin-Tian Hsu</name></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3407D290292E763B9E8E498F1E075FA91318001A</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/mds.20638</idno><idno type="url">https://api.istex.fr/document/3407D290292E763B9E8E498F1E075FA91318001A/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003566</idno><idno type="wicri:Area/Istex/Curation">003566</idno><idno type="wicri:Area/Istex/Checkpoint">002119</idno><idno type="wicri:doubleKey">0885-3185:2005:Momeni P:taiwanese:cases:of</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:16078202</idno><idno type="wicri:Area/PubMed/Corpus">002F57</idno><idno type="wicri:Area/PubMed/Curation">002F57</idno><idno type="wicri:Area/PubMed/Checkpoint">002F45</idno><idno type="wicri:Area/Ncbi/Merge">001355</idno><idno type="wicri:Area/Ncbi/Curation">001355</idno><idno type="wicri:Area/Ncbi/Checkpoint">001355</idno><idno type="wicri:doubleKey">0885-3185:2005:Momeni P:taiwanese:cases:of</idno><idno type="wicri:Area/Main/Merge">004D96</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Taiwanese cases of SCA2 are derived from a single founder</title><author><name sortKey="Momeni, Parastoo" sort="Momeni, Parastoo" uniqKey="Momeni P" first="Parastoo" last="Momeni">Parastoo Momeni</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lu, Chin Ong" sort="Lu, Chin Ong" uniqKey="Lu C" first="Chin-Song" last="Lu">Chin-Song Lu</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Neuroscience Research Center, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chou, Yah Uei Wu" sort="Chou, Yah Uei Wu" uniqKey="Chou Y" first="Yah-Huei Wu" last="Chou">Yah-Huei Wu Chou</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Neuroscience Research Center, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Human Molecular Genetics Laboratory, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Hsiu Hen" sort="Chang, Hsiu Hen" uniqKey="Chang H" first="Hsiu-Chen" last="Chang">Hsiu-Chen Chang</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Rou Hayn" sort="Chen, Rou Hayn" uniqKey="Chen R" first="Rou-Shayn" last="Chen">Rou-Shayn Chen</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Neuroscience Research Center, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Chiung Hu" sort="Chen, Chiung Hu" uniqKey="Chen C" first="Chiung-Chu" last="Chen">Chiung-Chu Chen</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Jin Ian" sort="Hsu, Jin Ian" uniqKey="Hsu J" first="Jin-Tian" last="Hsu">Jin-Tian Hsu</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Neurology, Kaohsiung Medical University, Chung‐Ho Memorial Hospital, Kaohsiung</wicri:regionArea><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-12">2005-12</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1633">1633</biblScope><biblScope unit="page" to="1636">1636</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3407D290292E763B9E8E498F1E075FA91318001A</idno><idno type="DOI">10.1002/mds.20638</idno><idno type="ArticleID">MDS20638</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Ataxia (genetics)</term><term>DNA Mutational Analysis</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nerve Tissue Proteins (genetics)</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>SCA2</term><term>Taiwan (ethnology)</term><term>ataxic phenotype</term><term>common founder</term><term>haplotype</term><term>parkinsonism</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Taiwan</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Ataxia</term><term>Parkinson Disease</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>DNA Mutational Analysis</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Taïwan</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have assessed the haplotypes at the ATXN2 locus in Taiwanese controls and in individuals with SCA2 ataxia with both ataxic and parkinsonian features. Our intention was to determine whether a different ataxin 2 haplotypes predisposed to the two phenotypes. In fact, our analysis showed that all SCA2 mutations carriers had the same ataxin 2 haplotype: haplotype B, which accounts for only 15% of control haplotypes, implying that there is a common founder for all Taiwanese SCA2 patients. © 2005 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.20638"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Taiwanese cases of SCA2 are derived from a single founder</title><author><name sortKey="Momeni, Parastoo" sort="Momeni, Parastoo" uniqKey="Momeni P" first="Parastoo" last="Momeni">Parastoo Momeni</name></author><author><name sortKey="Lu, Chin Ong" sort="Lu, Chin Ong" uniqKey="Lu C" first="Chin-Song" last="Lu">Chin-Song Lu</name></author><author><name sortKey="Chou, Yah Uei Wu" sort="Chou, Yah Uei Wu" uniqKey="Chou Y" first="Yah-Huei Wu" last="Chou">Yah-Huei Wu Chou</name></author><author><name sortKey="Chang, Hsiu Hen" sort="Chang, Hsiu Hen" uniqKey="Chang H" first="Hsiu-Chen" last="Chang">Hsiu-Chen Chang</name></author><author><name sortKey="Chen, Rou Hayn" sort="Chen, Rou Hayn" uniqKey="Chen R" first="Rou-Shayn" last="Chen">Rou-Shayn Chen</name></author><author><name sortKey="Chen, Chiung Hu" sort="Chen, Chiung Hu" uniqKey="Chen C" first="Chiung-Chu" last="Chen">Chiung-Chu Chen</name></author><author><name sortKey="Hsu, Jin Ian" sort="Hsu, Jin Ian" uniqKey="Hsu J" first="Jin-Tian" last="Hsu">Jin-Tian Hsu</name></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3407D290292E763B9E8E498F1E075FA91318001A</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/mds.20638</idno><idno type="url">https://api.istex.fr/document/3407D290292E763B9E8E498F1E075FA91318001A/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003566</idno><idno type="wicri:Area/Istex/Curation">003566</idno><idno type="wicri:Area/Istex/Checkpoint">002119</idno><idno type="wicri:doubleKey">0885-3185:2005:Momeni P:taiwanese:cases:of</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Taiwanese cases of SCA2 are derived from a single founder</title><author><name sortKey="Momeni, Parastoo" sort="Momeni, Parastoo" uniqKey="Momeni P" first="Parastoo" last="Momeni">Parastoo Momeni</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lu, Chin Ong" sort="Lu, Chin Ong" uniqKey="Lu C" first="Chin-Song" last="Lu">Chin-Song Lu</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Neuroscience Research Center, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chou, Yah Uei Wu" sort="Chou, Yah Uei Wu" uniqKey="Chou Y" first="Yah-Huei Wu" last="Chou">Yah-Huei Wu Chou</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Neuroscience Research Center, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Human Molecular Genetics Laboratory, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Hsiu Hen" sort="Chang, Hsiu Hen" uniqKey="Chang H" first="Hsiu-Chen" last="Chang">Hsiu-Chen Chang</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Rou Hayn" sort="Chen, Rou Hayn" uniqKey="Chen R" first="Rou-Shayn" last="Chen">Rou-Shayn Chen</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Neuroscience Research Center, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Chiung Hu" sort="Chen, Chiung Hu" uniqKey="Chen C" first="Chiung-Chu" last="Chen">Chiung-Chu Chen</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Movement Disorders Unit, Department of Neurology, Chang Gung Memorial Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hsu, Jin Ian" sort="Hsu, Jin Ian" uniqKey="Hsu J" first="Jin-Tian" last="Hsu">Jin-Tian Hsu</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Neurology, Kaohsiung Medical University, Chung‐Ho Memorial Hospital, Kaohsiung</wicri:regionArea><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-12">2005-12</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1633">1633</biblScope><biblScope unit="page" to="1636">1636</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3407D290292E763B9E8E498F1E075FA91318001A</idno><idno type="DOI">10.1002/mds.20638</idno><idno type="ArticleID">MDS20638</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>SCA2</term><term>ataxic phenotype</term><term>common founder</term><term>haplotype</term><term>parkinsonism</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have assessed the haplotypes at the ATXN2 locus in Taiwanese controls and in individuals with SCA2 ataxia with both ataxic and parkinsonian features. Our intention was to determine whether a different ataxin 2 haplotypes predisposed to the two phenotypes. In fact, our analysis showed that all SCA2 mutations carriers had the same ataxin 2 haplotype: haplotype B, which accounts for only 15% of control haplotypes, implying that there is a common founder for all Taiwanese SCA2 patients. © 2005 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Taiwanese cases of SCA2 are derived from a single founder.</title><author><name sortKey="Momeni, Parastoo" sort="Momeni, Parastoo" uniqKey="Momeni P" first="Parastoo" last="Momeni">Parastoo Momeni</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20952, USA. momeni@mail.nih.gov</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20952</wicri:regionArea><wicri:noRegion>Maryland 20952</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Chin Song" sort="Lu, Chin Song" uniqKey="Lu C" first="Chin-Song" last="Lu">Chin-Song Lu</name></author><author><name sortKey="Chou, Yah Huei Wu" sort="Chou, Yah Huei Wu" uniqKey="Chou Y" first="Yah-Huei Wu" last="Chou">Yah-Huei Wu Chou</name></author><author><name sortKey="Chang, Hsiu Chen" sort="Chang, Hsiu Chen" uniqKey="Chang H" first="Hsiu-Chen" last="Chang">Hsiu-Chen Chang</name></author><author><name sortKey="Chen, Rou Shayn" sort="Chen, Rou Shayn" uniqKey="Chen R" first="Rou-Shayn" last="Chen">Rou-Shayn Chen</name></author><author><name sortKey="Chen, Chiung Chu" sort="Chen, Chiung Chu" uniqKey="Chen C" first="Chiung-Chu" last="Chen">Chiung-Chu Chen</name></author><author><name sortKey="Hsu, Jin Tian" sort="Hsu, Jin Tian" uniqKey="Hsu J" first="Jin-Tian" last="Hsu">Jin-Tian Hsu</name></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20638</idno><idno type="RBID">pubmed:16078202</idno><idno type="pmid">16078202</idno><idno type="wicri:Area/PubMed/Corpus">002F57</idno><idno type="wicri:Area/PubMed/Curation">002F57</idno><idno type="wicri:Area/PubMed/Checkpoint">002F45</idno><idno type="wicri:Area/Ncbi/Merge">001355</idno><idno type="wicri:Area/Ncbi/Curation">001355</idno><idno type="wicri:Area/Ncbi/Checkpoint">001355</idno><idno type="wicri:doubleKey">0885-3185:2005:Momeni P:taiwanese:cases:of</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Taiwanese cases of SCA2 are derived from a single founder.</title><author><name sortKey="Momeni, Parastoo" sort="Momeni, Parastoo" uniqKey="Momeni P" first="Parastoo" last="Momeni">Parastoo Momeni</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20952, USA. momeni@mail.nih.gov</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20952</wicri:regionArea><wicri:noRegion>Maryland 20952</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Chin Song" sort="Lu, Chin Song" uniqKey="Lu C" first="Chin-Song" last="Lu">Chin-Song Lu</name></author><author><name sortKey="Chou, Yah Huei Wu" sort="Chou, Yah Huei Wu" uniqKey="Chou Y" first="Yah-Huei Wu" last="Chou">Yah-Huei Wu Chou</name></author><author><name sortKey="Chang, Hsiu Chen" sort="Chang, Hsiu Chen" uniqKey="Chang H" first="Hsiu-Chen" last="Chang">Hsiu-Chen Chang</name></author><author><name sortKey="Chen, Rou Shayn" sort="Chen, Rou Shayn" uniqKey="Chen R" first="Rou-Shayn" last="Chen">Rou-Shayn Chen</name></author><author><name sortKey="Chen, Chiung Chu" sort="Chen, Chiung Chu" uniqKey="Chen C" first="Chiung-Chu" last="Chen">Chiung-Chu Chen</name></author><author><name sortKey="Hsu, Jin Tian" sort="Hsu, Jin Tian" uniqKey="Hsu J" first="Jin-Tian" last="Hsu">Jin-Tian Hsu</name></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Ataxia (genetics)</term><term>DNA Mutational Analysis</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nerve Tissue Proteins (genetics)</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Taiwan (ethnology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Taiwan</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Ataxia</term><term>Parkinson Disease</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>DNA Mutational Analysis</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Taïwan</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have assessed the haplotypes at the ATXN2 locus in Taiwanese controls and in individuals with SCA2 ataxia with both ataxic and parkinsonian features. Our intention was to determine whether a different ataxin 2 haplotypes predisposed to the two phenotypes. In fact, our analysis showed that all SCA2 mutations carriers had the same ataxin 2 haplotype: haplotype B, which accounts for only 15% of control haplotypes, implying that there is a common founder for all Taiwanese SCA2 patients.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004D96 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 004D96 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Merge
|type= RBID
|clé= ISTEX:3407D290292E763B9E8E498F1E075FA91318001A
|texte= Taiwanese cases of SCA2 are derived from a single founder
}}
| This area was generated with Dilib version V0.6.23. |  |