MovDisordV3, Main, Merge, bibRecord, 004B74

Head of the caudate nucleus is most vulnerable in chorea-acanthocytosis : A voxel-based morphometry study

Identifieur interne : 004B74 ( Main/Merge ); précédent : 004B73; suivant : 004B75

Head of the caudate nucleus is most vulnerable in chorea-acanthocytosis : A voxel-based morphometry study

Auteurs : Karsten Henkel [Allemagne] ; Adrian Danek [Allemagne, États-Unis] ; Jordan Grafman [États-Unis] ; John Butman [États-Unis] ; Jan Kassubek [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0538595

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Chorée syndrome, Acanthocytose, Atrophie, Tête, Noyau caudé, Voxel, Morphométrie.

English descriptors

KwdEn :
- Acanthocytosis, Atrophy, Caudate nucleus, Chorea, Head, Morphometry, Nervous system diseases, Voxel.

Abstract

Chorea-acanthocytosis (ChAc; OMIM 200150) is a rare autosomal recessive disease with dysfunction of the erythrocyte membrane, presenting with acanthocytes and neurological manifestations characterized by progressive hyperkinesias (chorea, dystonia) and neuropsychological impairment. Damage to the basal ganglia was described previously in neuropathological and neuroimaging investigations. We analyzed high-resolution MRI of six ChAc patients with mutations in the VPS13A gene (median age, 37 years; mean time since clinical onset, 13 years) with respect to regional atrophy by use of the observer-independent technique of voxel-based morphometry in comparison to 15 age-matched healthy controls. Additionally, global brain atrophy was determined using the standardized brain parenchymal fraction (BPF) method. A robust regional reduction of gray matter density was observed in the head of the caudate nucleus bilaterally and was nearly symmetrical (P < 0.001, corrected for small volumes). No additional gray matter changes were found. In the BPF analysis, there was no significant global brain atrophy. The predilection of atrophy in the head of the caudate nucleus, as suggested by our results, argues for a particular vulnerability of this part of the striatum in ChAc and is in agreement with pronounced neuropsychological disturbances that are thought to rely on these regions.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001947
to stream PascalFrancis, to step Curation: 001374
to stream PascalFrancis, to step Checkpoint: 001A79

Links to Exploration step

Pascal:06-0538595

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Head of the caudate nucleus is most vulnerable in chorea-acanthocytosis : A voxel-based morphometry study</title>
<author><name sortKey="Henkel, Karsten" sort="Henkel, Karsten" uniqKey="Henkel K" first="Karsten" last="Henkel">Karsten Henkel</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, Ludwig-Maximilians-Universität Munich</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grafman, Jordan" sort="Grafman, Jordan" uniqKey="Grafman J" first="Jordan" last="Grafman">Jordan Grafman</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Butman, John" sort="Butman, John" uniqKey="Butman J" first="John" last="Butman">John Butman</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Clinical Center, National Institutes of Health</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">06-0538595</idno>
<date when="2006">2006</date>
<idno type="stanalyst">PASCAL 06-0538595 INIST</idno>
<idno type="RBID">Pascal:06-0538595</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001947</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001374</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001A79</idno>
<idno type="wicri:doubleKey">0885-3185:2006:Henkel K:head:of:the</idno>
<idno type="wicri:Area/Main/Merge">004B74</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Head of the caudate nucleus is most vulnerable in chorea-acanthocytosis : A voxel-based morphometry study</title>
<author><name sortKey="Henkel, Karsten" sort="Henkel, Karsten" uniqKey="Henkel K" first="Karsten" last="Henkel">Karsten Henkel</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology, Ludwig-Maximilians-Universität Munich</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grafman, Jordan" sort="Grafman, Jordan" uniqKey="Grafman J" first="Jordan" last="Grafman">Jordan Grafman</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Butman, John" sort="Butman, John" uniqKey="Butman J" first="John" last="Butman">John Butman</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Clinical Center, National Institutes of Health</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acanthocytosis</term>
<term>Atrophy</term>
<term>Caudate nucleus</term>
<term>Chorea</term>
<term>Head</term>
<term>Morphometry</term>
<term>Nervous system diseases</term>
<term>Voxel</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Chorée syndrome</term>
<term>Acanthocytose</term>
<term>Atrophie</term>
<term>Tête</term>
<term>Noyau caudé</term>
<term>Voxel</term>
<term>Morphométrie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Chorea-acanthocytosis (ChAc; OMIM 200150) is a rare autosomal recessive disease with dysfunction of the erythrocyte membrane, presenting with acanthocytes and neurological manifestations characterized by progressive hyperkinesias (chorea, dystonia) and neuropsychological impairment. Damage to the basal ganglia was described previously in neuropathological and neuroimaging investigations. We analyzed high-resolution MRI of six ChAc patients with mutations in the VPS13A gene (median age, 37 years; mean time since clinical onset, 13 years) with respect to regional atrophy by use of the observer-independent technique of voxel-based morphometry in comparison to 15 age-matched healthy controls. Additionally, global brain atrophy was determined using the standardized brain parenchymal fraction (BPF) method. A robust regional reduction of gray matter density was observed in the head of the caudate nucleus bilaterally and was nearly symmetrical (P < 0.001, corrected for small volumes). No additional gray matter changes were found. In the BPF analysis, there was no significant global brain atrophy. The predilection of atrophy in the head of the caudate nucleus, as suggested by our results, argues for a particular vulnerability of this part of the striatum in ChAc and is in agreement with pronounced neuropsychological disturbances that are thought to rely on these regions.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>États-Unis</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Bavière</li>
<li>District de Haute-Bavière</li>
<li>District de Tübingen</li>
<li>Maryland</li>
</region>
<settlement><li>Munich</li>
<li>Ulm</li>
</settlement>
<orgName><li>Université d'Ulm</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Henkel, Karsten" sort="Henkel, Karsten" uniqKey="Henkel K" first="Karsten" last="Henkel">Karsten Henkel</name>
</region>
<name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name>
<name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Danek, Adrian" sort="Danek, Adrian" uniqKey="Danek A" first="Adrian" last="Danek">Adrian Danek</name>
</region>
<name sortKey="Butman, John" sort="Butman, John" uniqKey="Butman J" first="John" last="Butman">John Butman</name>
<name sortKey="Grafman, Jordan" sort="Grafman, Jordan" uniqKey="Grafman J" first="Jordan" last="Grafman">Jordan Grafman</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004B74 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 004B74 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     Pascal:06-0538595
   |texte=   Head of the caudate nucleus is most vulnerable in chorea-acanthocytosis : A voxel-based morphometry study
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Head of the caudate nucleus is most vulnerable in chorea-acanthocytosis : A voxel-based morphometry study

Head of the caudate nucleus is most vulnerable in chorea-acanthocytosis : A voxel-based morphometry study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri