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Striatal dopaminergic neurons are lost with Parkinson's disease progression

Identifieur interne : 004985 ( Main/Merge ); précédent : 004984; suivant : 004986

Striatal dopaminergic neurons are lost with Parkinson's disease progression

Auteurs : Michelle J. Porritt [Australie] ; Ann E. Kingsbury [Royaume-Uni] ; Andrew J. Hughes [Australie] ; David W. Howells [Australie]

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:07-0090880

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Neurone dopaminergique.

English descriptors

KwdEn :
- Dopaminergic neuron, Nervous system diseases, Parkinson disease.

Abstract

Increased numbers of dopaminergic neurons are described in the striatum of patients with Parkinson's disease. In postmortem striatal tissue from Parkinson's disease patients with short disease duration (≤8 years), the number of dopaminergic neurons is approximately four times that in patients with long duration (≥16 years). The data suggest the possibility that the presence of large numbers of these striatal dopaminergic neurons may be harmful and may accelerate the disease process. Alternatively, these neurons may be lost to the disease process.

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Pascal:07-0090880

Le document en format XML

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<author><name sortKey="Howells, David W" sort="Howells, David W" uniqKey="Howells D" first="David W." last="Howells">David W. Howells</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Striatal dopaminergic neurons are lost with Parkinson's disease progression</title>
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<author><name sortKey="Howells, David W" sort="Howells, David W" uniqKey="Howells D" first="David W." last="Howells">David W. Howells</name>
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<series><title level="j" type="main">Movement disorders</title>
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<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
<term>Neurone dopaminergique</term>
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<front><div type="abstract" xml:lang="en">Increased numbers of dopaminergic neurons are described in the striatum of patients with Parkinson's disease. In postmortem striatal tissue from Parkinson's disease patients with short disease duration (≤8 years), the number of dopaminergic neurons is approximately four times that in patients with long duration (≥16 years). The data suggest the possibility that the presence of large numbers of these striatal dopaminergic neurons may be harmful and may accelerate the disease process. Alternatively, these neurons may be lost to the disease process.</div>
</front>
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<tree><country name="Australie"><noRegion><name sortKey="Porritt, Michelle J" sort="Porritt, Michelle J" uniqKey="Porritt M" first="Michelle J." last="Porritt">Michelle J. Porritt</name>
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<name sortKey="Howells, David W" sort="Howells, David W" uniqKey="Howells D" first="David W." last="Howells">David W. Howells</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kingsbury, Ann E" sort="Kingsbury, Ann E" uniqKey="Kingsbury A" first="Ann E." last="Kingsbury">Ann E. Kingsbury</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Striatal dopaminergic neurons are lost with Parkinson's disease progression

Striatal dopaminergic neurons are lost with Parkinson's disease progression

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri