MovDisordV3, Main, Merge, bibRecord, 004962

The sequence effect and gait festination in parkinson disease : Contributors to freezing of gait?

Identifieur interne : 004962 ( Main/Merge ); précédent : 004961; suivant : 004963

The sequence effect and gait festination in parkinson disease : Contributors to freezing of gait?

Auteurs : Robert Iansek [Australie] ; Frances Huxham [Australie] ; Jennifer Mcginley [Australie]

Source :

Movement disorders [ 0885-3185 ] ; 2006.

RBID : Pascal:06-0518096

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Congélation, Noyau gris central.
Wicri :
- topic : Congélation.

English descriptors

KwdEn :
- Basal ganglion, Freezing, Nervous system diseases, Parkinson disease.

Abstract

Festination and freezing of gait (FOG) are poorly understood gait disorders that cause disability and falls in people with Parkinson disease (PD). In PD, basal ganglia malfunction leads to motor set deficits (hypokinesia), while altered motor cue production leads to a sequence effect, whereby movements becomes progressively smaller as in festination. We suggest both factors may contribute to FOG. Disturbance of set maintenance by the basal ganglia in PD has previously been examined in gait, but limited systematic evaluation of the sequence effect exists. In this study, we investigated the step-to-step amplitude relationship in 10 PD subjects with clinical evidence of festination and FOG. Four conditions were examined: off levodopa, ojfwith attentional strategies, off with visual cues, and on levodopa. Participants demonstrated a sequence effect (F = 6.24; P = 0.001), which was reversed only by use of visual cues. In contrast, medication, attentional strategies, and visual cues all improved hypokinesia. Variability was marked both within and between participants in all conditions. The variability of FOG is suggested to relate to a combination of factors, including the sequence effect and its variability, as well as the severity of hypokinesia and its response to medications.

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Pascal:06-0518096

Le document en format XML

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<front><div type="abstract" xml:lang="en">Festination and freezing of gait (FOG) are poorly understood gait disorders that cause disability and falls in people with Parkinson disease (PD). In PD, basal ganglia malfunction leads to motor set deficits (hypokinesia), while altered motor cue production leads to a sequence effect, whereby movements becomes progressively smaller as in festination. We suggest both factors may contribute to FOG. Disturbance of set maintenance by the basal ganglia in PD has previously been examined in gait, but limited systematic evaluation of the sequence effect exists. In this study, we investigated the step-to-step amplitude relationship in 10 PD subjects with clinical evidence of festination and FOG. Four conditions were examined: off levodopa, ojfwith attentional strategies, off with visual cues, and on levodopa. Participants demonstrated a sequence effect (F = 6.24; P = 0.001), which was reversed only by use of visual cues. In contrast, medication, attentional strategies, and visual cues all improved hypokinesia. Variability was marked both within and between participants in all conditions. The variability of FOG is suggested to relate to a combination of factors, including the sequence effect and its variability, as well as the severity of hypokinesia and its response to medications.</div>
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	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

The sequence effect and gait festination in parkinson disease : Contributors to freezing of gait?

The sequence effect and gait festination in parkinson disease : Contributors to freezing of gait?

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri