Topography of putaminal degeneration in multiple system atrophy : A diffusion magnetic resonance study
Identifieur interne : 004960 ( Main/Merge ); précédent : 004959; suivant : 004961Topography of putaminal degeneration in multiple system atrophy : A diffusion magnetic resonance study
Auteurs : Klaus Seppi [Autriche] ; Michael F. H. Schocke [Autriche] ; Kathrin Prennschuetz-Schuetzenau [Autriche] ; Katherina J. Mair [Autriche] ; Regina Esterhammer [Autriche] ; Christian Kremser [Autriche] ; Armin Muigg [Autriche] ; Christoph Scherfler [Autriche] ; Werner Jaschke [Autriche] ; Gregor K. Wenning [Autriche] ; Werner Poewe [Autriche]Source :
- Movement disorders [ 0885-3185 ] ; 2006.
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Abstract
There is neuropathologic evidence that, in early stages of the Parkinson variant of multiple system atrophy (MSA-P), the putamen shows a distinct topographical pathology affecting predominantly the dorsolateral and caudal regions while leaving the rostral to midparts almost intact. We investigated the topographic profile of putaminal degeneration in MSA-P patients in vivo by means of diffusion-weighted imaging (DWI), which has been shown to reveal abnormalities in the basal ganglia of patients with MSA-P compared to patients with PD and healthy controls. For this purpose, regional trace of the diffusion tensor (rTrace(D)) values were determined in the entire, anterior, and posterior putamen in 15 patients with probable MSA-P, in 20 patients with PD, and in 11 healthy volunteers matched for age and disease duration. MSA-P patients had significantly higher rTrace(D) values in entire, anterior, and posterior putamen compared to both controls and PD patients. Trace(D) values were significantly higher in the posterior compared to the anterior putamen in the MSA-P group. There were no significant differences between posterior and anterior putamen in both the control and PD group. Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA-P in vivo by assessing putaminal diffusivity with the help of DWI.
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H." last="Schocke">Michael F. H. Schocke</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology 1, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Radiology 1, Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Prennschuetz Schuetzenau, Kathrin" sort="Prennschuetz Schuetzenau, Kathrin" uniqKey="Prennschuetz Schuetzenau K" first="Kathrin" last="Prennschuetz-Schuetzenau">Kathrin Prennschuetz-Schuetzenau</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Mair, Katherina J" sort="Mair, Katherina J" uniqKey="Mair K" first="Katherina J." last="Mair">Katherina J. Mair</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Esterhammer, Regina" sort="Esterhammer, Regina" uniqKey="Esterhammer R" first="Regina" last="Esterhammer">Regina Esterhammer</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology 1, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Radiology 1, Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Kremser, Christian" sort="Kremser, Christian" uniqKey="Kremser C" first="Christian" last="Kremser">Christian Kremser</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology 1, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Radiology 1, Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Muigg, Armin" sort="Muigg, Armin" uniqKey="Muigg A" first="Armin" last="Muigg">Armin Muigg</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Jaschke, Werner" sort="Jaschke, Werner" uniqKey="Jaschke W" first="Werner" last="Jaschke">Werner Jaschke</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Radiology 1, Innsbruck Medical University</s1><s3>AUT</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Radiology 1, Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Innsbruck Medical University</s1><s3>AUT</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Department of Neurology, Innsbruck Medical University</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Degeneration</term><term>Diffusion</term><term>Diffusion imaging</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Putamen</term><term>Topography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Dégénérescence</term><term>Atrophie multisystématisée</term><term>Topographie</term><term>Diffusion</term><term>Putamen</term><term>Imagerie RMN</term><term>Imagerie de diffusion</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is neuropathologic evidence that, in early stages of the Parkinson variant of multiple system atrophy (MSA-P), the putamen shows a distinct topographical pathology affecting predominantly the dorsolateral and caudal regions while leaving the rostral to midparts almost intact. We investigated the topographic profile of putaminal degeneration in MSA-P patients in vivo by means of diffusion-weighted imaging (DWI), which has been shown to reveal abnormalities in the basal ganglia of patients with MSA-P compared to patients with PD and healthy controls. For this purpose, regional trace of the diffusion tensor (rTrace(D)) values were determined in the entire, anterior, and posterior putamen in 15 patients with probable MSA-P, in 20 patients with PD, and in 11 healthy volunteers matched for age and disease duration. MSA-P patients had significantly higher rTrace(D) values in entire, anterior, and posterior putamen compared to both controls and PD patients. Trace(D) values were significantly higher in the posterior compared to the anterior putamen in the MSA-P group. There were no significant differences between posterior and anterior putamen in both the control and PD group. Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA-P in vivo by assessing putaminal diffusivity with the help of DWI.</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></noRegion><name sortKey="Esterhammer, Regina" sort="Esterhammer, Regina" uniqKey="Esterhammer R" first="Regina" last="Esterhammer">Regina Esterhammer</name><name sortKey="Jaschke, Werner" sort="Jaschke, Werner" uniqKey="Jaschke W" first="Werner" last="Jaschke">Werner Jaschke</name><name sortKey="Kremser, Christian" sort="Kremser, Christian" uniqKey="Kremser C" first="Christian" last="Kremser">Christian Kremser</name><name sortKey="Mair, Katherina J" sort="Mair, Katherina J" uniqKey="Mair K" first="Katherina J." last="Mair">Katherina J. Mair</name><name sortKey="Muigg, Armin" sort="Muigg, Armin" uniqKey="Muigg A" first="Armin" last="Muigg">Armin Muigg</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Prennschuetz Schuetzenau, Kathrin" sort="Prennschuetz Schuetzenau, Kathrin" uniqKey="Prennschuetz Schuetzenau K" first="Kathrin" last="Prennschuetz-Schuetzenau">Kathrin Prennschuetz-Schuetzenau</name><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><name sortKey="Schocke, Michael F H" sort="Schocke, Michael F H" uniqKey="Schocke M" first="Michael F. H." last="Schocke">Michael F. H. Schocke</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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