Association of the Tau haplotype with Parkinson's disease in the Greek population
Identifieur interne : 004895 ( Main/Merge ); précédent : 004894; suivant : 004896Association of the Tau haplotype with Parkinson's disease in the Greek population
Auteurs : Liana Fidani [Grèce] ; Kallirhoe Kalinderi [Grèce] ; Sevasti Bostantjopoulou [Grèce] ; Jordi Clarimon [États-Unis] ; Antonis Goulas [Grèce] ; Zoe Katsarou [Grèce] ; John Hardy [États-Unis, Royaume-Uni] ; Alexandros Kotsis [Grèce]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-07.
English descriptors
- KwdEn :
- Aged, Female, Gene Frequency (genetics), Genetics, Population, Genotype, Haplotypes, Humans, Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (genetics), Parkinson's disease, Polymorphism, Genetic (genetics), Reference Values, Tau, haplotypes, polymorphisms, tau Proteins (genetics).
- MESH :
- chemical , genetics : tau Proteins.
- diagnosis : Parkinson Disease.
- genetics : Gene Frequency, Parkinson Disease, Polymorphism, Genetic.
- Aged, Female, Genetics, Population, Genotype, Haplotypes, Humans, Male, Middle Aged, Reference Values.
Abstract
We compared the distribution of the Tau H1 haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece. We were able to detect a statistically significant overrepresentation of the H1H1 genotype in our patient group (OR for H1H1 vs. H1H2 and H2H2: 1.73; 95% CI: 1.03–2.90; P = 0.037). The H1 subhaplotype significantly associated with the disease in our population was different from the one previously reported for a Norwegian population, suggesting that the nature of the association of Tau with Parkinson's disease is influenced by ethnic variation. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20864
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-07">2006-07</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1036">1036</biblScope><biblScope unit="page" to="1039">1039</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FE408D31BD7F869F1E0C44F6E0690AB8A6473BC5</idno><idno type="DOI">10.1002/mds.20864</idno><idno type="ArticleID">MDS20864</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Female</term><term>Gene Frequency (genetics)</term><term>Genetics, Population</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (genetics)</term><term>Parkinson's disease</term><term>Polymorphism, Genetic (genetics)</term><term>Reference Values</term><term>Tau</term><term>haplotypes</term><term>polymorphisms</term><term>tau Proteins (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Frequency</term><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Genetics, Population</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared the distribution of the Tau H1 haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece. We were able to detect a statistically significant overrepresentation of the H1H1 genotype in our patient group (OR for H1H1 vs. H1H2 and H2H2: 1.73; 95% CI: 1.03–2.90; P = 0.037). The H1 subhaplotype significantly associated with the disease in our population was different from the one previously reported for a Norwegian population, suggesting that the nature of the association of Tau with Parkinson's disease is influenced by ethnic variation. © 2006 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.20864"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of the Tau haplotype with Parkinson's disease in the Greek population</title><author><name sortKey="Fidani, Liana" sort="Fidani, Liana" uniqKey="Fidani L" first="Liana" last="Fidani">Liana Fidani</name></author><author><name sortKey="Kalinderi, Kallirhoe" sort="Kalinderi, Kallirhoe" uniqKey="Kalinderi K" first="Kallirhoe" last="Kalinderi">Kallirhoe Kalinderi</name></author><author><name sortKey="Bostantjopoulou, Sevasti" sort="Bostantjopoulou, Sevasti" uniqKey="Bostantjopoulou S" first="Sevasti" last="Bostantjopoulou">Sevasti Bostantjopoulou</name></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name></author><author><name sortKey="Goulas, Antonis" sort="Goulas, Antonis" uniqKey="Goulas A" first="Antonis" last="Goulas">Antonis Goulas</name></author><author><name sortKey="Katsarou, Zoe" sort="Katsarou, Zoe" uniqKey="Katsarou Z" first="Zoe" last="Katsarou">Zoe Katsarou</name></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></author><author><name sortKey="Kotsis, Alexandros" sort="Kotsis, Alexandros" uniqKey="Kotsis A" first="Alexandros" last="Kotsis">Alexandros Kotsis</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FE408D31BD7F869F1E0C44F6E0690AB8A6473BC5</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1002/mds.20864</idno><idno type="url">https://api.istex.fr/document/FE408D31BD7F869F1E0C44F6E0690AB8A6473BC5/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003299</idno><idno type="wicri:Area/Istex/Curation">003299</idno><idno type="wicri:Area/Istex/Checkpoint">002041</idno><idno type="wicri:doubleKey">0885-3185:2006:Fidani L:association:of:the</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Association of the Tau haplotype with Parkinson's disease in the Greek population</title><author><name sortKey="Fidani, Liana" sort="Fidani, Liana" uniqKey="Fidani L" first="Liana" last="Fidani">Liana Fidani</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Kalinderi, Kallirhoe" sort="Kalinderi, Kallirhoe" uniqKey="Kalinderi K" first="Kallirhoe" last="Kalinderi">Kallirhoe Kalinderi</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Bostantjopoulou, Sevasti" sort="Bostantjopoulou, Sevasti" uniqKey="Bostantjopoulou S" first="Sevasti" last="Bostantjopoulou">Sevasti Bostantjopoulou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Third Department of Neurology, G. Papanikolau Hospital, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Goulas, Antonis" sort="Goulas, Antonis" uniqKey="Goulas A" first="Antonis" last="Goulas">Antonis Goulas</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Katsarou, Zoe" sort="Katsarou, Zoe" uniqKey="Katsarou Z" first="Zoe" last="Katsarou">Zoe Katsarou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Third Department of Neurology, G. Papanikolau Hospital, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kotsis, Alexandros" sort="Kotsis, Alexandros" uniqKey="Kotsis A" first="Alexandros" last="Kotsis">Alexandros Kotsis</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-07">2006-07</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1036">1036</biblScope><biblScope unit="page" to="1039">1039</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FE408D31BD7F869F1E0C44F6E0690AB8A6473BC5</idno><idno type="DOI">10.1002/mds.20864</idno><idno type="ArticleID">MDS20864</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>Tau</term><term>haplotypes</term><term>polymorphisms</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared the distribution of the Tau H1 haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece. We were able to detect a statistically significant overrepresentation of the H1H1 genotype in our patient group (OR for H1H1 vs. H1H2 and H2H2: 1.73; 95% CI: 1.03–2.90; P = 0.037). The H1 subhaplotype significantly associated with the disease in our population was different from the one previously reported for a Norwegian population, suggesting that the nature of the association of Tau with Parkinson's disease is influenced by ethnic variation. © 2006 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association of the Tau haplotype with Parkinson's disease in the Greek population.</title><author><name sortKey="Fidani, Liana" sort="Fidani, Liana" uniqKey="Fidani L" first="Liana" last="Fidani">Liana Fidani</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. lfidani@med.auth.gr</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Kalinderi, Kallirhoe" sort="Kalinderi, Kallirhoe" uniqKey="Kalinderi K" first="Kallirhoe" last="Kalinderi">Kallirhoe Kalinderi</name></author><author><name sortKey="Bostantjopoulou, Sevasti" sort="Bostantjopoulou, Sevasti" uniqKey="Bostantjopoulou S" first="Sevasti" last="Bostantjopoulou">Sevasti Bostantjopoulou</name></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name></author><author><name sortKey="Goulas, Antonis" sort="Goulas, Antonis" uniqKey="Goulas A" first="Antonis" last="Goulas">Antonis Goulas</name></author><author><name sortKey="Katsarou, Zoe" sort="Katsarou, Zoe" uniqKey="Katsarou Z" first="Zoe" last="Katsarou">Zoe Katsarou</name></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></author><author><name sortKey="Kotsis, Alexandros" sort="Kotsis, Alexandros" uniqKey="Kotsis A" first="Alexandros" last="Kotsis">Alexandros Kotsis</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20864</idno><idno type="RBID">pubmed:16552760</idno><idno type="pmid">16552760</idno><idno type="wicri:Area/PubMed/Corpus">002D10</idno><idno type="wicri:Area/PubMed/Curation">002D10</idno><idno type="wicri:Area/PubMed/Checkpoint">002E68</idno><idno type="wicri:Area/Ncbi/Merge">001621</idno><idno type="wicri:Area/Ncbi/Curation">001621</idno><idno type="wicri:Area/Ncbi/Checkpoint">001621</idno><idno type="wicri:doubleKey">0885-3185:2006:Fidani L:association:of:the</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Association of the Tau haplotype with Parkinson's disease in the Greek population.</title><author><name sortKey="Fidani, Liana" sort="Fidani, Liana" uniqKey="Fidani L" first="Liana" last="Fidani">Liana Fidani</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. lfidani@med.auth.gr</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Kalinderi, Kallirhoe" sort="Kalinderi, Kallirhoe" uniqKey="Kalinderi K" first="Kallirhoe" last="Kalinderi">Kallirhoe Kalinderi</name></author><author><name sortKey="Bostantjopoulou, Sevasti" sort="Bostantjopoulou, Sevasti" uniqKey="Bostantjopoulou S" first="Sevasti" last="Bostantjopoulou">Sevasti Bostantjopoulou</name></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name></author><author><name sortKey="Goulas, Antonis" sort="Goulas, Antonis" uniqKey="Goulas A" first="Antonis" last="Goulas">Antonis Goulas</name></author><author><name sortKey="Katsarou, Zoe" sort="Katsarou, Zoe" uniqKey="Katsarou Z" first="Zoe" last="Katsarou">Zoe Katsarou</name></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></author><author><name sortKey="Kotsis, Alexandros" sort="Kotsis, Alexandros" uniqKey="Kotsis A" first="Alexandros" last="Kotsis">Alexandros Kotsis</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Female</term><term>Gene Frequency (genetics)</term><term>Genetics, Population</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Genetic (genetics)</term><term>Reference Values</term><term>tau Proteins (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Frequency</term><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Genetics, Population</term><term>Genotype</term><term>Haplotypes</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We compared the distribution of the Tau H1 haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece. We were able to detect a statistically significant overrepresentation of the H1H1 genotype in our patient group (OR for H1H1 vs. H1H2 and H2H2: 1.73; 95% CI: 1.03-2.90; P = 0.037). The H1 subhaplotype significantly associated with the disease in our population was different from the one previously reported for a Norwegian population, suggesting that the nature of the association of Tau with Parkinson's disease is influenced by ethnic variation.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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