Correlation between cardiac 123I‐MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy
Identifieur interne : 004823 ( Main/Merge ); précédent : 004822; suivant : 004824Correlation between cardiac 123I‐MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy
Auteurs : Phil Hyu Lee [Corée du Sud] ; Seung Hyeon Yeo [Corée du Sud] ; Hyun Joon Kim [Corée du Sud] ; Hyo Young Youm [Corée du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-11.
English descriptors
- KwdEn :
- 3-Iodobenzylguanidine (chemistry), Aged, Female, Heart (drug effects), Heart (radionuclide imaging), Humans, Male, Middle Aged, Multiple System Atrophy (physiopathology), Multiple System Atrophy (radionuclide imaging), Odors, Parkinson Disease (physiopathology), Parkinson Disease (radionuclide imaging), Parkinson's disease, Radiopharmaceuticals (chemistry), Smell (drug effects), Smell (physiology), Statistics as Topic, cardiac MIBG, olfactory function.
- MESH :
- chemical , chemistry : 3-Iodobenzylguanidine, Radiopharmaceuticals.
- drug effects : Heart, Smell.
- physiology : Smell.
- physiopathology : Multiple System Atrophy, Parkinson Disease.
- radionuclide imaging : Heart, Multiple System Atrophy, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Odors, Statistics as Topic.
Abstract
We investigated an association between olfaction and cardiac 123I‐metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). There was a significant positive correlation between cardiac MIBG uptake and the Cross‐Cultural Smell Identification (CCSI) score in patients with PD (r = 0.56; P = 0.003) independent of the disease duration or clinical rating of motor status. However, patients with MSA did not show a significant correlation between cardiac MIBG uptake and the CCSI score. Our findings suggest that the functional losses of the olfactory and cardiac sympathetic systems are closely coupled in PD. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21083
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<front><div type="abstract" xml:lang="en">We investigated an association between olfaction and cardiac 123I‐metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). There was a significant positive correlation between cardiac MIBG uptake and the Cross‐Cultural Smell Identification (CCSI) score in patients with PD (r = 0.56; P = 0.003) independent of the disease duration or clinical rating of motor status. However, patients with MSA did not show a significant correlation between cardiac MIBG uptake and the CCSI score. Our findings suggest that the functional losses of the olfactory and cardiac sympathetic systems are closely coupled in PD. © 2006 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">We investigated an association between olfaction and cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). There was a significant positive correlation between cardiac MIBG uptake and the Cross-Cultural Smell Identification (CCSI) score in patients with PD (r = 0.56; P = 0.003) independent of the disease duration or clinical rating of motor status. However, patients with MSA did not show a significant correlation between cardiac MIBG uptake and the CCSI score. Our findings suggest that the functional losses of the olfactory and cardiac sympathetic systems are closely coupled in PD.</div>
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