Recessive Parkinson's disease
Identifieur interne : 004534 ( Main/Merge ); précédent : 004533; suivant : 004535Recessive Parkinson's disease
Auteurs : Shin-Ichiro Kubo [Japon] ; Nobutaka Hattori [Japon] ; Yoshikuni Mizuno [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-07.
English descriptors
- KwdEn :
- DJ‐1, Dopamine (metabolism), Humans, Intracellular Signaling Peptides and Proteins (genetics), Mitochondria (genetics), Mitochondria (physiology), Oncogene Proteins (genetics), Oxidative Stress (genetics), Oxidative Stress (physiology), PINK1, Parkinsonian Disorders (diagnosis), Parkinsonian Disorders (genetics), Parkinsonian Disorders (physiopathology), Phenotype, Proteasome Endopeptidase Complex (genetics), Proteasome Endopeptidase Complex (physiology), Protein Kinases (genetics), Substantia Nigra (physiopathology), Ubiquitin (genetics), Ubiquitin (metabolism), Ubiquitin-Protein Ligases (genetics), mitochondria, oxidative stress, parkin, recessive Parkinson's disease, ubiquitin–proteasome system.
- MESH :
- chemical , genetics : Intracellular Signaling Peptides and Proteins, Oncogene Proteins, Proteasome Endopeptidase Complex, Protein Kinases, Ubiquitin, Ubiquitin-Protein Ligases.
- chemical , metabolism : Dopamine, Ubiquitin.
- diagnosis : Parkinsonian Disorders.
- genetics : Mitochondria, Oxidative Stress, Parkinsonian Disorders.
- physiology : Mitochondria, Oxidative Stress, Proteasome Endopeptidase Complex.
- physiopathology : Parkinsonian Disorders, Substantia Nigra.
- Humans, Phenotype.
Abstract
Parkinson's disease (PD) is a progressive neurodegenerative disease caused by loss of dopaminergic neurons in the substantia nigra pars compacta. Although the etiology of PD remains unclear, it is now clear that genetic factors contribute to the pathogenesis of the disease. Recently, several causative genes have been identified in monogenic forms of PD. Accumulating evidence indicates that their gene products play important roles in mitochondrial function, oxidative stress response, and the ubiquitin–proteasome system, which are also implicated in sporadic PD, suggesting that these gene products share a common pathway to nigral degeneration in both familial and sporadic PD. Here, we review recent advances in knowledge about genes associated with recessive PD, including parkin, PINK1, and DJ‐1. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20841
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a progressive neurodegenerative disease caused by loss of dopaminergic neurons in the substantia nigra pars compacta. Although the etiology of PD remains unclear, it is now clear that genetic factors contribute to the pathogenesis of the disease. Recently, several causative genes have been identified in monogenic forms of PD. Accumulating evidence indicates that their gene products play important roles in mitochondrial function, oxidative stress response, and the ubiquitin–proteasome system, which are also implicated in sporadic PD, suggesting that these gene products share a common pathway to nigral degeneration in both familial and sporadic PD. Here, we review recent advances in knowledge about genes associated with recessive PD, including parkin, PINK1, and DJ‐1. © 2006 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a progressive neurodegenerative disease caused by loss of dopaminergic neurons in the substantia nigra pars compacta. Although the etiology of PD remains unclear, it is now clear that genetic factors contribute to the pathogenesis of the disease. Recently, several causative genes have been identified in monogenic forms of PD. Accumulating evidence indicates that their gene products play important roles in mitochondrial function, oxidative stress response, and the ubiquitin-proteasome system, which are also implicated in sporadic PD, suggesting that these gene products share a common pathway to nigral degeneration in both familial and sporadic PD. Here, we review recent advances in knowledge about genes associated with recessive PD, including parkin, PINK1, and DJ-1.</div>
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