Comparison of Brain MRI and 18F-FDG PET in the Differential Diagnosis of Multiple System Atrophy from Parkinson's Disease
Identifieur interne : 004327 ( Main/Merge ); précédent : 004326; suivant : 004328Comparison of Brain MRI and 18F-FDG PET in the Differential Diagnosis of Multiple System Atrophy from Parkinson's Disease
Auteurs : Kyum-Yil Kwon [Corée du Sud] ; Choong G. Choi [Corée du Sud] ; Jae S. Kim [Corée du Sud] ; Myoung C. Lee [Corée du Sud] ; Sun J. Chung [Corée du Sud]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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Abstract
To investigate the diagnostic value of brain magnetic resonance image (MRI) and 18F-fluorodeoxy glucose positron emission tomography (18F-FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty-five patients with MSA (23 MSA-P and 12 MSA-C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA-P, MSA-C, and PD patients were 80% for visual MRI analysis, 88.5% for visual 18F-FDG PET analysis, and 84.3% for SPM-supported analysis of 18F-FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of 18F-FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and 18F-FDG PET are diagnostically useful in differentiating MSA (MSA-P and MSA-C) from PD, and indicate that 18F-FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Comparison of Brain MRI and <sup>18</sup>F-FDG PET in the Differential Diagnosis of Multiple System Atrophy from Parkinson's Disease</title><author><name sortKey="Kwon, Kyum Yil" sort="Kwon, Kyum Yil" uniqKey="Kwon K" first="Kyum-Yil" last="Kwon">Kyum-Yil Kwon</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Choi, Choong G" sort="Choi, Choong G" uniqKey="Choi C" first="Choong G." last="Choi">Choong G. Choi</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S." last="Kim">Jae S. Kim</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>3 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0147878</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 08-0147878 INIST</idno><idno type="RBID">Pascal:08-0147878</idno><idno type="wicri:Area/PascalFrancis/Corpus">001354</idno><idno type="wicri:Area/PascalFrancis/Curation">001965</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001737</idno><idno type="wicri:doubleKey">0885-3185:2007:Kwon K:comparison:of:brain</idno><idno type="wicri:Area/Main/Merge">004327</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Comparison of Brain MRI and <sup>18</sup>F-FDG PET in the Differential Diagnosis of Multiple System Atrophy from Parkinson's Disease</title><author><name sortKey="Kwon, Kyum Yil" sort="Kwon, Kyum Yil" uniqKey="Kwon K" first="Kyum-Yil" last="Kwon">Kyum-Yil Kwon</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Choi, Choong G" sort="Choi, Choong G" uniqKey="Choi C" first="Choong G." last="Choi">Choong G. Choi</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S." last="Kim">Jae S. Kim</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>3 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Comparative study</term><term>Differential diagnostic</term><term>Emission tomography</term><term>Encephalon</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term><term>Positron</term><term>Positron emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Etude comparative</term><term>Encéphale</term><term>Imagerie RMN</term><term>Tomoscintigraphie</term><term>Positon</term><term>Tomographie par émission de positons</term><term>Diagnostic différentiel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the diagnostic value of brain magnetic resonance image (MRI) and <sup>18</sup>F-fluorodeoxy glucose positron emission tomography (<sup>18</sup>F-FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty-five patients with MSA (23 MSA-P and 12 MSA-C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA-P, MSA-C, and PD patients were 80% for visual MRI analysis, 88.5% for visual <sup>18</sup>F-FDG PET analysis, and 84.3% for SPM-supported analysis of <sup>18</sup>F-FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of <sup>18</sup>F-FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and <sup>18</sup>F-FDG PET are diagnostically useful in differentiating MSA (MSA-P and MSA-C) from PD, and indicate that <sup>18</sup>F-FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kwon, Kyum Yil" sort="Kwon, Kyum Yil" uniqKey="Kwon K" first="Kyum-Yil" last="Kwon">Kyum-Yil Kwon</name></noRegion><name sortKey="Choi, Choong G" sort="Choi, Choong G" uniqKey="Choi C" first="Choong G." last="Choi">Choong G. Choi</name><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S." last="Kim">Jae S. Kim</name><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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