Comparison of Brain MRI and 18F-FDG PET in the Differential Diagnosis of Multiple System Atrophy from Parkinson's Disease
Identifieur interne : 004327 ( Main/Merge ); précédent : 004326; suivant : 004328Comparison of Brain MRI and 18F-FDG PET in the Differential Diagnosis of Multiple System Atrophy from Parkinson's Disease
Auteurs : Kyum-Yil Kwon [Corée du Sud] ; Choong G. Choi [Corée du Sud] ; Jae S. Kim [Corée du Sud] ; Myoung C. Lee [Corée du Sud] ; Sun J. Chung [Corée du Sud]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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- Pascal (Inist)
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Abstract
To investigate the diagnostic value of brain magnetic resonance image (MRI) and 18F-fluorodeoxy glucose positron emission tomography (18F-FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty-five patients with MSA (23 MSA-P and 12 MSA-C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA-P, MSA-C, and PD patients were 80% for visual MRI analysis, 88.5% for visual 18F-FDG PET analysis, and 84.3% for SPM-supported analysis of 18F-FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of 18F-FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and 18F-FDG PET are diagnostically useful in differentiating MSA (MSA-P and MSA-C) from PD, and indicate that 18F-FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings.
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F-FDG PET in the Differential Diagnosis of Multiple System Atrophy from Parkinson's Disease</title>
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F-FDG PET in the Differential Diagnosis of Multiple System Atrophy from Parkinson's Disease</title>
<author><name sortKey="Kwon, Kyum Yil" sort="Kwon, Kyum Yil" uniqKey="Kwon K" first="Kyum-Yil" last="Kwon">Kyum-Yil Kwon</name>
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<author><name sortKey="Choi, Choong G" sort="Choi, Choong G" uniqKey="Choi C" first="Choong G." last="Choi">Choong G. Choi</name>
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<author><name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S." last="Kim">Jae S. Kim</name>
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<author><name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine</s1>
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<author><name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Comparative study</term>
<term>Differential diagnostic</term>
<term>Emission tomography</term>
<term>Encephalon</term>
<term>Multiple system atrophy</term>
<term>Nervous system diseases</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Parkinson disease</term>
<term>Positron</term>
<term>Positron emission tomography</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Etude comparative</term>
<term>Encéphale</term>
<term>Imagerie RMN</term>
<term>Tomoscintigraphie</term>
<term>Positon</term>
<term>Tomographie par émission de positons</term>
<term>Diagnostic différentiel</term>
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<front><div type="abstract" xml:lang="en">To investigate the diagnostic value of brain magnetic resonance image (MRI) and <sup>18</sup>
F-fluorodeoxy glucose positron emission tomography (<sup>18</sup>
F-FDG PET) in the differentiation of multiple system atrophy (MSA) from Parkinson's disease (PD). Thirty-five patients with MSA (23 MSA-P and 12 MSA-C) and 17 patients with PD were included in this study. Overall correct diagnosis rates between clinical and imaging diagnosis among MSA-P, MSA-C, and PD patients were 80% for visual MRI analysis, 88.5% for visual <sup>18</sup>
F-FDG PET analysis, and 84.3% for SPM-supported analysis of <sup>18</sup>
F-FDG PET. The sensitivity of brain MRI, and visual and SPM analysis of <sup>18</sup>
F-FDG PET in differentiating MSA from PD was 72.7%, 90.9%, and 95.5%, respectively, the specificity was 100% for each imaging analysis, the positive predictive value was 100% for each imaging analysis, and the negative predictive value was 60%, 81.8%, and 90%, respectively. Our results suggest that brain MRI and <sup>18</sup>
F-FDG PET are diagnostically useful in differentiating MSA (MSA-P and MSA-C) from PD, and indicate that <sup>18</sup>
F-FDG PET has a tendency toward higher sensitivity compared to brain MRI, but a larger longitudinal study including pathological data will be required to confirm our findings.</div>
</front>
</TEI>
<affiliations><list><country><li>Corée du Sud</li>
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<settlement><li>Séoul</li>
</settlement>
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<tree><country name="Corée du Sud"><noRegion><name sortKey="Kwon, Kyum Yil" sort="Kwon, Kyum Yil" uniqKey="Kwon K" first="Kyum-Yil" last="Kwon">Kyum-Yil Kwon</name>
</noRegion>
<name sortKey="Choi, Choong G" sort="Choi, Choong G" uniqKey="Choi C" first="Choong G." last="Choi">Choong G. Choi</name>
<name sortKey="Chung, Sun J" sort="Chung, Sun J" uniqKey="Chung S" first="Sun J." last="Chung">Sun J. Chung</name>
<name sortKey="Kim, Jae S" sort="Kim, Jae S" uniqKey="Kim J" first="Jae S." last="Kim">Jae S. Kim</name>
<name sortKey="Lee, Myoung C" sort="Lee, Myoung C" uniqKey="Lee M" first="Myoung C." last="Lee">Myoung C. Lee</name>
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</record>
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