MovDisordV3, Main, Merge, bibRecord, 004216

Isolated frontal disequilibrium as presenting form of anti-hu paraneoplastic encephalomyelitis

Identifieur interne : 004216 ( Main/Merge ); précédent : 004215; suivant : 004217

Isolated frontal disequilibrium as presenting form of anti-hu paraneoplastic encephalomyelitis

Auteurs : Yaroslau Compta [Espagne] ; Francesc Valldeoriola [Espagne] ; Xabier Urra [Espagne] ; Beatriz Gomez-Anson [Espagne] ; Lorena Rami [Espagne] ; Eduardo Tolosa [Espagne] ; Francesc Graus [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0263047

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Paranéoplasique syndrome, Encéphalomyélite, Frontal.

English descriptors

KwdEn :
- Encephalomyelitis, Frontal, Nervous system diseases, Paraneoplastic syndrome.

Abstract

Anti-Hu encephalomyelitis is one of the most frequent paraneoplastic syndromes, classically presenting with diffuse neurological involvement. We report a 69-year-old man presenting with a three-month isolated, progressive gait disorder with normal neurological examination, except for loss of balance and gait failure reminding frontal disequilibrium, only accompanied by a very mild rigidity of his right foot. MRI of the brain showed hyperintensities in both amygdale and left putamen. EMG study showed no abnormal continuous spontaneous fiber activity. Because of fast progression and MRI findings, anti-Hu antibodies were tested, resulting positive. Mediastinal biopsy of two adenopathies detected by body-PET, confirmed an oat-cell carcinoma. The patient received oral steroids and oncological therapy. One year later, the tumor is in remission. His gait and abnormal posture of right leg are normal. Only mild residual hyperintensities persist on follow-up MRI. A paraneoplastic syndrome should be considered in the differential diagnosis of subacute, fast progressive gait disorders.

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Pascal:07-0263047

Le document en format XML

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<front><div type="abstract" xml:lang="en">Anti-Hu encephalomyelitis is one of the most frequent paraneoplastic syndromes, classically presenting with diffuse neurological involvement. We report a 69-year-old man presenting with a three-month isolated, progressive gait disorder with normal neurological examination, except for loss of balance and gait failure reminding frontal disequilibrium, only accompanied by a very mild rigidity of his right foot. MRI of the brain showed hyperintensities in both amygdale and left putamen. EMG study showed no abnormal continuous spontaneous fiber activity. Because of fast progression and MRI findings, anti-Hu antibodies were tested, resulting positive. Mediastinal biopsy of two adenopathies detected by body-PET, confirmed an oat-cell carcinoma. The patient received oral steroids and oncological therapy. One year later, the tumor is in remission. His gait and abnormal posture of right leg are normal. Only mild residual hyperintensities persist on follow-up MRI. A paraneoplastic syndrome should be considered in the differential diagnosis of subacute, fast progressive gait disorders.</div>
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<tree><country name="Espagne"><noRegion><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name>
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<name sortKey="Gomez Anson, Beatriz" sort="Gomez Anson, Beatriz" uniqKey="Gomez Anson B" first="Beatriz" last="Gomez-Anson">Beatriz Gomez-Anson</name>
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<name sortKey="Rami, Lorena" sort="Rami, Lorena" uniqKey="Rami L" first="Lorena" last="Rami">Lorena Rami</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
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<name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Isolated frontal disequilibrium as presenting form of anti-hu paraneoplastic encephalomyelitis

Isolated frontal disequilibrium as presenting form of anti-hu paraneoplastic encephalomyelitis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri