Long-term cognitive profile and incidence of dementia after STN-DBS in Parkinson's disease
Identifieur interne : 004200 ( Main/Merge ); précédent : 004199; suivant : 004201Long-term cognitive profile and incidence of dementia after STN-DBS in Parkinson's disease
Auteurs : Selma Aybek [Suisse] ; Aline Gronchi-Perrin [Suisse] ; Alexandre Berney [Suisse] ; Sabina Catalano Chiuve [Suisse] ; Jean-Guy Villemure [Suisse] ; Pierre R. Burkhard [Suisse] ; Francois J. G. Vingerhoets [Suisse]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
An effect of subthalamic nucleus deep brain stimulation (STN-DBS) on cognition has been suspected but long-term observations are lacking. The aim of this study was to evaluate the long-term cognitive profile and the incidence of dementia in a cohort of Parkinson's disease (PD) patients treated by STN-DBS. 57 consecutive patients were prospectively assessed by the mean of a neuropsychological battery over 3 years after surgery. Dementia (DSM-IV) and UPDRS I to IV were recorded. 24.5% of patients converted to dementia over 3 years (incidence of 89 of 1,000 per year). This group of patients cognitively continuously worsened over 3 years up to fulfilling dementia criteria (PDD). The rest of the cohort remained cognitively stable (PD) over the whole follow-up. Preoperative differences between PDD and PD included older age (69.2 ± 5.8 years; 62.6 ± 8 years), presence of hallucinations and poorer executive score (10.1 ± 5.9; 5.5 ± 4.4). The incidence of dementia over 3 years after STN-DBS is similar to the one reported in medically treated patients. The PDD presented preoperative risk factors of developing dementia similar to those described in medically treated patients. These observations suggest dementia being secondary to the natural evolution of PD rather than a direct effect of STN-DBS.
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Burkhard</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Service de Neurochirurgie, CHUV</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>6 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Vingerhoets, Francois J G" sort="Vingerhoets, Francois J G" uniqKey="Vingerhoets F" first="Francois J. G." last="Vingerhoets">Francois J. G. Vingerhoets</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Service de Neurologie, CHUV</s1><s2>Lausanne</s2><s3>CHE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dementia</term><term>Incidence</term><term>Long term</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term><term>Démence</term><term>Parkinson maladie</term><term>Long terme</term><term>Incidence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An effect of subthalamic nucleus deep brain stimulation (STN-DBS) on cognition has been suspected but long-term observations are lacking. The aim of this study was to evaluate the long-term cognitive profile and the incidence of dementia in a cohort of Parkinson's disease (PD) patients treated by STN-DBS. 57 consecutive patients were prospectively assessed by the mean of a neuropsychological battery over 3 years after surgery. Dementia (DSM-IV) and UPDRS I to IV were recorded. 24.5% of patients converted to dementia over 3 years (incidence of 89 of 1,000 per year). This group of patients cognitively continuously worsened over 3 years up to fulfilling dementia criteria (PDD). The rest of the cohort remained cognitively stable (PD) over the whole follow-up. Preoperative differences between PDD and PD included older age (69.2 ± 5.8 years; 62.6 ± 8 years), presence of hallucinations and poorer executive score (10.1 ± 5.9; 5.5 ± 4.4). The incidence of dementia over 3 years after STN-DBS is similar to the one reported in medically treated patients. The PDD presented preoperative risk factors of developing dementia similar to those described in medically treated patients. These observations suggest dementia being secondary to the natural evolution of PD rather than a direct effect of STN-DBS.</div></front></TEI><affiliations><list><country><li>Suisse</li></country><region><li>Canton de Vaud</li></region><settlement><li>Lausanne</li></settlement></list><tree><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Aybek, Selma" sort="Aybek, Selma" uniqKey="Aybek S" first="Selma" last="Aybek">Selma Aybek</name></region><name sortKey="Berney, Alexandre" sort="Berney, Alexandre" uniqKey="Berney A" first="Alexandre" last="Berney">Alexandre Berney</name><name sortKey="Burkhard, Pierre R" sort="Burkhard, Pierre R" uniqKey="Burkhard P" first="Pierre R." last="Burkhard">Pierre R. Burkhard</name><name sortKey="Catalano Chiuve, Sabina" sort="Catalano Chiuve, Sabina" uniqKey="Catalano Chiuve S" first="Sabina" last="Catalano Chiuve">Sabina Catalano Chiuve</name><name sortKey="Gronchi Perrin, Aline" sort="Gronchi Perrin, Aline" uniqKey="Gronchi Perrin A" first="Aline" last="Gronchi-Perrin">Aline Gronchi-Perrin</name><name sortKey="Villemure, Jean Guy" sort="Villemure, Jean Guy" uniqKey="Villemure J" first="Jean-Guy" last="Villemure">Jean-Guy Villemure</name><name sortKey="Vingerhoets, Francois J G" sort="Vingerhoets, Francois J G" uniqKey="Vingerhoets F" first="Francois J. G." last="Vingerhoets">Francois J. G. Vingerhoets</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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