Neuroinflammation in the pathophysiology of parkinson's disease : Evidence from animal models to human in vivo studies with [11C]-PK11195 PET
Identifieur interne : 004161 ( Main/Merge ); précédent : 004160; suivant : 004162Neuroinflammation in the pathophysiology of parkinson's disease : Evidence from animal models to human in vivo studies with [11C]-PK11195 PET
Auteurs : Anna L. Bartels [Pays-Bas] ; Klaus L. Leenders [Pays-Bas]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
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Abstract
Increasing evidence suggests that neuroinflammation is an active process in Parkinson's disease (PD) that contributes to ongoing neurodegeneration. PD brains and experimental PD models show elevated cytokine levels and up-regulation of inflammatory-associated factors as cyclo-oxygenase-2 and inducible nitric oxide oxidase. Antiinflammatory treatment reduced neuronal degeneration in experimental models. In this review, we summarize the place of neuroinflammation in the pathophysiology of PD. In vivo PET studies are discussed. These methods provide a means to monitor in vivo potential clinical relevance of antiinflammatory treatment strategies in PD.
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Pascal:08-0015783Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Neuroinflammation in the pathophysiology of parkinson's disease : Evidence from animal models to human in vivo studies with [<sup>11</sup>C]-PK11195 PET</title><author><name sortKey="Bartels, Anna L" sort="Bartels, Anna L" uniqKey="Bartels A" first="Anna L." last="Bartels">Anna L. Bartels</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Medical Centre Groningen (UMCG), University of Groningen, Hanzeplein</s1><s2>9700 RB Groningen</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Leenders, Klaus L" sort="Leenders, Klaus L" uniqKey="Leenders K" first="Klaus L." last="Leenders">Klaus L. Leenders</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Medical Centre Groningen (UMCG), University of Groningen, Hanzeplein</s1><s2>9700 RB Groningen</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0015783</idno><date when="2007">2007</date><idno type="stanalyst">PASCAL 08-0015783 INIST</idno><idno type="RBID">Pascal:08-0015783</idno><idno type="wicri:Area/PascalFrancis/Corpus">001518</idno><idno type="wicri:Area/PascalFrancis/Curation">001801</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001571</idno><idno type="wicri:doubleKey">0885-3185:2007:Bartels A:neuroinflammation:in:the</idno><idno type="wicri:Area/Main/Merge">004161</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Neuroinflammation in the pathophysiology of parkinson's disease : Evidence from animal models to human in vivo studies with [<sup>11</sup>C]-PK11195 PET</title><author><name sortKey="Bartels, Anna L" sort="Bartels, Anna L" uniqKey="Bartels A" first="Anna L." last="Bartels">Anna L. Bartels</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Medical Centre Groningen (UMCG), University of Groningen, Hanzeplein</s1><s2>9700 RB Groningen</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Leenders, Klaus L" sort="Leenders, Klaus L" uniqKey="Leenders K" first="Klaus L." last="Leenders">Klaus L. Leenders</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, University Medical Centre Groningen (UMCG), University of Groningen, Hanzeplein</s1><s2>9700 RB Groningen</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term><term>Emission tomography</term><term>Human</term><term>Microglia</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Pathophysiology</term><term>Positron</term><term>Positron emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term><term>Maladie de Parkinson</term><term>Physiopathologie</term><term>Modèle animal</term><term>Homme</term><term>Tomoscintigraphie</term><term>Positon</term><term>Tomographie par émission de positons</term><term>Microglie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Increasing evidence suggests that neuroinflammation is an active process in Parkinson's disease (PD) that contributes to ongoing neurodegeneration. PD brains and experimental PD models show elevated cytokine levels and up-regulation of inflammatory-associated factors as cyclo-oxygenase-2 and inducible nitric oxide oxidase. Antiinflammatory treatment reduced neuronal degeneration in experimental models. In this review, we summarize the place of neuroinflammation in the pathophysiology of PD. In vivo PET studies are discussed. These methods provide a means to monitor in vivo potential clinical relevance of antiinflammatory treatment strategies in PD.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Bartels, Anna L" sort="Bartels, Anna L" uniqKey="Bartels A" first="Anna L." last="Bartels">Anna L. Bartels</name></noRegion><name sortKey="Leenders, Klaus L" sort="Leenders, Klaus L" uniqKey="Leenders K" first="Klaus L." last="Leenders">Klaus L. Leenders</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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