Predictors of Punding in Parkinson's Disease : Results from a Questionnaire Survey
Identifieur interne : 004117 ( Main/Merge ); précédent : 004116; suivant : 004118Predictors of Punding in Parkinson's Disease : Results from a Questionnaire Survey
Auteurs : Andrew J. Lawrence [Royaume-Uni] ; Andrew D. Blackwell [Royaume-Uni] ; Roger A. Barker [Royaume-Uni] ; Francesca Spagnolo [Italie] ; Luke Clark [Royaume-Uni] ; Michael R. F. Aitken [Royaume-Uni] ; Barbara J. Sahakian [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
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- Pascal (Inist)
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Abstract
Dopamine replacement therapy (DRT) for Parkinson's disease (PD) has recently been linked to the development of a number of nonmotor behavioral control problems. Punding, one of these nonmotor problems, is a term used to describe complex, purposeless stereotyped behaviors such as the repetitive handling or sorting of objects. A self-report questionnaire was adapted to assess punding in the context of dysfunctional hobby-related activities. We report the results of a survey of PD outpatients from a PD research clinic (n = 141) and non-PD controls (n = 103); conducted to identify clinical and psychological factors predictive of punding behaviors. The PD group reported hobbies and activities, which scored significantly higher on the Punding Scale than controls. Higher impulsivity, poorer disease-related quality of life, younger age of disease onset, and concomitant daily medication dosage from dopamine receptor agonists were independently predictive of higher Punding Scale scores in the PD group. These findings are similar to those seen in dopamine dysregulation syndrome, and provide further evidence for the role of impulsivity and age at disease onset in DRT-related nonmotor behavioral problems in PD.
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Lawrence</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Experimental Psychology, University of Cambridge</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Behavioural and Clinical Neuroscience Institute, University of Cambridge</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Blackwell, Andrew D" sort="Blackwell, Andrew D" uniqKey="Blackwell A" first="Andrew D." last="Blackwell">Andrew D. Blackwell</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Cambridge School of Medicine</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Behavioural and Clinical Neuroscience Institute, University of Cambridge</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Cambridge Centre for Brain Repair, Department of Clinical Neuroscience, Addenbrooke's Hospital</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Spagnolo, Francesca" sort="Spagnolo, Francesca" uniqKey="Spagnolo F" first="Francesca" last="Spagnolo">Francesca Spagnolo</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, San Raffaele Hospital</s1><s2>Milan</s2><s3>ITA</s3><sZ>4 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Clark, Luke" sort="Clark, Luke" uniqKey="Clark L" first="Luke" last="Clark">Luke Clark</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Experimental Psychology, University of Cambridge</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Behavioural and Clinical Neuroscience Institute, University of Cambridge</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Aitken, Michael R F" sort="Aitken, Michael R F" uniqKey="Aitken M" first="Michael R. F." last="Aitken">Michael R. F. Aitken</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Experimental Psychology, University of Cambridge</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Behavioural and Clinical Neuroscience Institute, University of Cambridge</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Sahakian, Barbara J" sort="Sahakian, Barbara J" uniqKey="Sahakian B" first="Barbara J." last="Sahakian">Barbara J. Sahakian</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Behavioural and Clinical Neuroscience Institute, University of Cambridge</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Cambridge School of Medicine</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of onset</term><term>Behavioral disorder</term><term>Compulsion</term><term>Dopamine</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Questionnaire</term><term>Survey</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble du comportement</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Questionnaire</term><term>Enquête</term><term>Dopamine</term><term>Compulsion</term><term>Age apparition</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopamine replacement therapy (DRT) for Parkinson's disease (PD) has recently been linked to the development of a number of nonmotor behavioral control problems. Punding, one of these nonmotor problems, is a term used to describe complex, purposeless stereotyped behaviors such as the repetitive handling or sorting of objects. A self-report questionnaire was adapted to assess punding in the context of dysfunctional hobby-related activities. We report the results of a survey of PD outpatients from a PD research clinic (n = 141) and non-PD controls (n = 103); conducted to identify clinical and psychological factors predictive of punding behaviors. The PD group reported hobbies and activities, which scored significantly higher on the Punding Scale than controls. Higher impulsivity, poorer disease-related quality of life, younger age of disease onset, and concomitant daily medication dosage from dopamine receptor agonists were independently predictive of higher Punding Scale scores in the PD group. These findings are similar to those seen in dopamine dysregulation syndrome, and provide further evidence for the role of impulsivity and age at disease onset in DRT-related nonmotor behavioral problems in PD.</div></front></TEI><affiliations><list><country><li>Italie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Lombardie</li></region><settlement><li>Cambridge</li><li>Milan</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lawrence, Andrew J" sort="Lawrence, Andrew J" uniqKey="Lawrence A" first="Andrew J." last="Lawrence">Andrew J. Lawrence</name></region><name sortKey="Aitken, Michael R F" sort="Aitken, Michael R F" uniqKey="Aitken M" first="Michael R. F." last="Aitken">Michael R. F. Aitken</name><name sortKey="Aitken, Michael R F" sort="Aitken, Michael R F" uniqKey="Aitken M" first="Michael R. F." last="Aitken">Michael R. F. Aitken</name><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name><name sortKey="Blackwell, Andrew D" sort="Blackwell, Andrew D" uniqKey="Blackwell A" first="Andrew D." last="Blackwell">Andrew D. Blackwell</name><name sortKey="Clark, Luke" sort="Clark, Luke" uniqKey="Clark L" first="Luke" last="Clark">Luke Clark</name><name sortKey="Clark, Luke" sort="Clark, Luke" uniqKey="Clark L" first="Luke" last="Clark">Luke Clark</name><name sortKey="Lawrence, Andrew J" sort="Lawrence, Andrew J" uniqKey="Lawrence A" first="Andrew J." last="Lawrence">Andrew J. Lawrence</name><name sortKey="Sahakian, Barbara J" sort="Sahakian, Barbara J" uniqKey="Sahakian B" first="Barbara J." last="Sahakian">Barbara J. Sahakian</name><name sortKey="Sahakian, Barbara J" sort="Sahakian, Barbara J" uniqKey="Sahakian B" first="Barbara J." last="Sahakian">Barbara J. Sahakian</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Spagnolo, Francesca" sort="Spagnolo, Francesca" uniqKey="Spagnolo F" first="Francesca" last="Spagnolo">Francesca Spagnolo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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