MovDisordV3, Main, Merge, bibRecord, 004049

Smoking and cognitive function in Parkinson's disease

Identifieur interne : 004049 ( Main/Merge ); précédent : 004048; suivant : 004050

Smoking and cognitive function in Parkinson's disease

Auteurs : Marc G. Weisskopf [États-Unis] ; Francine Grodstein [États-Unis] ; Alberto Ascherio [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0263031

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Tabagisme, Parkinson maladie, Prospective, Epidémiologie, Facteur risque.
Wicri :
- topic : Tabagisme, Prospective.

English descriptors

KwdEn :
- Epidemiology, Nervous system diseases, Parkinson disease, Prospective, Risk factor, Tobacco smoking.

Abstract

The risk of dementia among Parkinson's disease (PD) patients is greatly elevated compared to controls, yet little is known about determinants of cognitive function among PD patients. We assessed the relation between cigarette smoking prior to disease onset and later cognitive function among PD patients (n = 286) and age- and sex-matched controls (n = 1144) participating in the Nurses' Health Study and Health Professionals Follow-up Study. Both groups completed telephone-administered assessments of cognitive function. We used linear regression to calculate mean differences in cognitive test scores across smoking categories, adjusted for age, education, sex, age at onset of PD, and years since diagnosis. PD patients scored significantly worse on all tests than their matched controls. In analyses only among PD cases, but not among controls, current smokers at PD onset scored worse than never smokers on the Telephone Interview for Cognitive Status (difference - -0.82, 95% CI: -1.33, -0.30, P = 0.002) as well as on a global score combining results of all tests (difference - -0.36, 95% CI: -0.72, 0.01, P = 0.06). This difference was equivalent to the difference in global score observed among controls ∼ 10 years apart in age. Analyses of pack-years of smoking prior to disease onset gave similar results. These findings, nested in prospective cohort studies, suggest that cigarette smoking prior to disease onset is associated with worse cognitive function in PD.

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Pascal:07-0263031

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Smoking and cognitive function in Parkinson's disease</title>
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<front><div type="abstract" xml:lang="en">The risk of dementia among Parkinson's disease (PD) patients is greatly elevated compared to controls, yet little is known about determinants of cognitive function among PD patients. We assessed the relation between cigarette smoking prior to disease onset and later cognitive function among PD patients (n = 286) and age- and sex-matched controls (n = 1144) participating in the Nurses' Health Study and Health Professionals Follow-up Study. Both groups completed telephone-administered assessments of cognitive function. We used linear regression to calculate mean differences in cognitive test scores across smoking categories, adjusted for age, education, sex, age at onset of PD, and years since diagnosis. PD patients scored significantly worse on all tests than their matched controls. In analyses only among PD cases, but not among controls, current smokers at PD onset scored worse than never smokers on the Telephone Interview for Cognitive Status (difference - -0.82, 95% CI: -1.33, -0.30, P = 0.002) as well as on a global score combining results of all tests (difference - -0.36, 95% CI: -0.72, 0.01, P = 0.06). This difference was equivalent to the difference in global score observed among controls ∼ 10 years apart in age. Analyses of pack-years of smoking prior to disease onset gave similar results. These findings, nested in prospective cohort studies, suggest that cigarette smoking prior to disease onset is associated with worse cognitive function in PD.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Smoking and cognitive function in Parkinson's disease

Smoking and cognitive function in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri